DRSC/TRiP Functional Genomics Resources

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Protein Alignment NOTCH4 and crb

DIOPT Version :10

Sequence 1:NP_004548.3 Gene:NOTCH4 / 4855 HGNCID:7884 Length:2003 Species:Homo sapiens
Sequence 2:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster


Alignment Length:2090 Identity:466/2090 - (22%)
Similarity:639/2090 - (30%) Gaps:876/2090 - (41%)


- Green bases have known domain annotations that are detailed below.


Human    33 EPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPD--PCQNAQLCQNGGSCQALLPAPLGLPSSPS 95
            :||...|||.|...|. .|:|...:.|:.||..:  ||.. ..|:|||||         |.:|..
  Fly   272 DPCMGHGTCSSSPEGY-ECRCTARYSGKNCQKDNGSPCAK-NPCENGGSC---------LENSRG 325

Human    96 PLTPSFLCTCLPGFTGERCQAK--LEDPCPPSFCSKRGRC-HIQASGRPQCSCMPGWTGEQCQL- 156
                .:.|.|.|..:|:.|:.:  :...|..:.|...|.| .|..||...|.|..|:.|.:|:: 
  Fly   326 ----DYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEVD 386

Human   157 RDFCSANPCVNGGVCLATYPQIQCHCP-PGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQC 220
            .|.|::.||.|.|.|:.......|.|. .|:.|..|:.:|:||  |..||..|..|.:|.|.:.|
  Fly   387 TDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDEC--DKNPCLNGGRCFDTYGWYTC 449

Human   221 LCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNP-------- 277
            .|..|..|..|: |...|..:.|.|||||.   :|...|. |||||.:.|..|::.|        
  Fly   450 QCLDGWGGEICD-RPMTCQTQQCLNGGTCL---DKPIGFQ-CLCPPEYTGELCQIAPSCAQQCPI 509

Human   278 ----------------------------------------------------------------- 277
                                                                             
  Fly   510 DSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTS 574

Human   278 ----------------------------DNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSED 314
                                        :.|....|.|||||......|:|:|...:||::|...
  Fly   575 RTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTS 639

Human   315 VDE-----------CE-TQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPG 367
            ..:           |. |.|  .|.|||||  |....||.|..|:.|..||: .::|....|...
  Fly   640 TGDGASALALTPINCNATNG--KCLNGGTC--SMNGTHCYCAVGYSGDRCEK-AENCSPLNCQEP 699

Human   368 STCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQD 432
            ..|:..    .||||..:   :|   :.|.:|||....:|...| .|...|.|..|::|.||..|
  Fly   700 MVCVQN----QCLCPENK---VC---NQCATQPCQNGGECVDLP-NGDYECKCTRGWTGRTCGND 753

Human   433 LDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATF 497
            :|||.:   .|..|.: |.|.|..||:.|.|.||:||..|::|.:||||.||..|:||.:.:..:
  Fly   754 VDECTL---HPKICGN-GICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAY 814

Human   498 HCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCAN 562
            .|:|.||.||:.|||:.:||.|.||.|.:.|.|.:|.|.|.|:||.:|..|:.|||:|...||.|
  Fly   815 ECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLN 879

Human   563 GGQCQDQPGAFHCKCL-PGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEV 626
            ||||.||.|.|.|.|. .|:||..|:..:|||||:||..||.|||....:||.|.:|:.|:.||.
  Fly   880 GGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQ 944

Human   627 PL--CAPNLCQPKQICKDQKDKA--------------------------NCLCPDGSPG--CAPP 661
            .:  |..|.||....|.::.:..                          .|:|..|..|  |...
  Fly   945 DINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEIN 1009

Human   662 EDNCTCH----HGHCQRS----SCVCDVGWTGPECEAELGGCIS-APCAHGGTCYPQPSGYNCTC 717
            .:.|..:    ||:|...    :|.|:.|:.|..||..:..|.. .||.. ||||.|...|:|.|
  Fly  1010 INECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEINIDECDRYNPCQR-GTCYDQIDDYDCDC 1073

Human   718 PTGYTGPTCSEEMTACHSGPCLNGGSC-----NPSPGGYYCTCPPSHTGPQCQTS---------- 767
            ...|.|..||..:..|...||||||:|     |.....|.|||.....|.:|:.:          
  Fly  1074 DANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSL 1138

Human   768 ----------------------------------------------------------------- 767
                                                                             
  Fly  1139 ISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIG 1203

Human   768 ----------------------------------------------------------------- 767
                                                                             
  Fly  1204 SKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHL 1268

Human   768 --------------------------------------------TDYCVSAPCFNGGTCVNRPGT 788
                                                        |:.|...||.:.|.|.:...|
  Fly  1269 THQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECTDLWHT 1333

Human   789 FSCLCAMGFQGPRCE-------------------------------------------------- 803
            |:|.|...|.|..|:                                                  
  Fly  1334 FACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTGQVF 1398

Human   804 -------------------------GKL------------------------------------- 806
                                     |:|                                     
  Fly  1399 YLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLV 1463

Human   807 ----------------------------------------------------------------- 806
                                                                             
  Fly  1464 QVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEA 1528

Human   807 ------------------------------------------------RPS----------CADS 813
                                                            |.|          |..:
  Fly  1529 DDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLCRKN 1593

Human   814 PCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTG-- 876
            ||.:.|.|:::.....|.||.||.|.:||.: :.|....||..|.|......:.|:....:||  
  Fly  1594 PCLHNAECRNTWNDYTCKCPNGYKGKNCQEI-EFCQHVTCPGQSLCQNLDDGYECVTNTTFTGQE 1657

Human   877 --PLC----------NLPLSSCQKAALSQGIDVSSLCHNGG--LCVDSGPSYF------------ 915
              ||.          ::...:..|..|...||::.....||  |.:|:...:|            
  Fly  1658 RSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEIGVNGGRVTIT 1722

Human   916 -----------------------------CH----------------CPPGF------------- 922
                                         .|                ..|.|             
  Fly  1723 WKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESMVDPTPAFSTDIDQAAFQSLI 1787

Human   923 -------------------------QGS----------------------------------LCQ 928
                                     |||                                  ..|
  Fly  1788 ATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAELYSRTNVSVQQKAQ 1852

Human   929 DHVNP---------CESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCT 984
            ..:|.         |....|:|...|.:....|.|.|.||::|.:|..::|.|.:..|.|:|||.
  Fly  1853 FRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGDDCGTDIDECLNTECLNNGTCI 1917

Human   985 PKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEV-EID 1048
            .:...|.|.|.|||.|..||.::|||.|||||..|.  |..|..::.|.|...:.|..|:| :..
  Fly  1918 NQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGN--CTDLIASYVCDCPEDYMGPQCDVLKQM 1980

Human  1049 PCHSQPCFHGGTCE----ATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPG 1109
            .|.::||.:|.||:    |:.|:  .|.|.|..|||||.|.  .|.|....|.:|||||.:   |
  Fly  1981 TCENEPCRNGSTCQNGFNASTGN--NFTCTCVPGFEGPLCD--IPFCEITPCDNGGLCLTT---G 2038

Human  1110 FPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPG 1174
            ..|.|.|..||.|..|  ......| ..:||...|.|.:..|      |..|.       ||..|
  Fly  2039 AVPMCKCSLGYTGRLC--EQDINEC-ESNPCQNGGQCKDLVG------RYECD-------CQGTG 2087

Human  1175 AKGCEGRSGDGACDAGCSGPGGNWDGGDC-SLGVPDPWKGCPSHSRCWLLFRDGQC---HPQCDS 1235
            .:|....:....|         |.:|..| .||            ||:......||   .|.|.:
  Fly  2088 FEGIRCENDIDEC---------NMEGDYCGGLG------------RCFNKPGSFQCICQKPYCGA 2131

Human  1236 EECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNT-----AEC--GWDGGDCRPEDGDPEW 1293
             .|.|.. .|.....|:           :.|.|.:.|..     .||  |:.|.:|.......|.
  Fly  2132 -YCNFTD-PCNATDLCS-----------NGGRCVESCGAKPDYYCECPEGFAGKNCTAPITAKED 2183

Human  1294 GPSLALLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPT 1358
            |||...:.::..|.          |:.|.|..|..:     |..:|.    ||.:....||..|:
  Fly  2184 GPSTTDIAIIVIPV----------VVVLLLIAGALL-----GTFLVM----ARNKRATRGTYSPS 2229

Human  1359 YQERAAPQTQ 1368
            .||...|:.:
  Fly  2230 AQEYCNPRLE 2239

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH4NP_004548.3 EGF_CA 194..225 CDD:429571 12/30 (40%)
EGF 280..308 CDD:394967 10/27 (37%)
EGF_CA 314..353 CDD:238011 15/50 (30%)
EGF_CA <364..390 CDD:238011 6/25 (24%)
EGF_CA 432..473 CDD:238011 17/40 (43%)
EGF_CA 475..511 CDD:238011 16/35 (46%)
EGF_CA 515..549 CDD:238011 15/33 (45%)
EGF_CA 551..587 CDD:238011 20/36 (56%)
EGF_CA 590..625 CDD:238011 17/34 (50%)
EGF_CA <699..726 CDD:238011 12/26 (46%)
EGF_CA <736..765 CDD:238011 13/33 (39%)
EGF_CA 769..803 CDD:238011 11/33 (33%)
EGF_CA <813..842 CDD:238011 10/28 (36%)
EGF_CA <899..928 CDD:238011 11/159 (7%)
EGF_CA 931..965 CDD:238011 11/42 (26%)
EGF_CA 970..1004 CDD:238011 14/33 (42%)
EGF_CA 1047..1084 CDD:238011 16/40 (40%)
Notch 1168..1204 CDD:459658 8/36 (22%)
LNR 1 1170..1213 10/43 (23%)
Notch 1211..1246 CDD:459658 8/37 (22%)
LNR 2 1214..1250 9/38 (24%)
Notch 1249..1285 CDD:459658 8/42 (19%)
LNR 3 1251..1294 10/49 (20%)
NOD 1295..1344 CDD:462014 9/48 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1347..1371 6/22 (27%)
NODP 1379..>1420 CDD:462229
JMTM_Notch4 1431..1515 CDD:411988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1485..1508
ANK repeat 1586..1630 CDD:293786
ANKYR <1619..1823 CDD:440430
ANK 1 1633..1665
ANK repeat 1634..1664 CDD:293786
ANK repeat 1666..1698 CDD:293786
ANK 2 1666..1698
ANK 3 1700..1732
ANK repeat 1700..1731 CDD:293786
ANK 4 1733..1765
ANK repeat 1733..1764 CDD:293786
ANK 5 1766..1798
ANK repeat 1766..1797 CDD:293786
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1900..1927
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..2003
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF 269..299 CDD:394967 10/27 (37%)
EGF_CA <311..341 CDD:238011 12/42 (29%)
EGF_CA 386..423 CDD:238011 11/36 (31%)
EGF_CA 425..460 CDD:238011 14/36 (39%)
EGF 466..495 CDD:394967 14/32 (44%)
EGF 605..633 CDD:394967 10/27 (37%)
EGF_CA 716..750 CDD:238011 11/34 (32%)
EGF_CA 753..789 CDD:238011 17/39 (44%)
EGF_CA 792..828 CDD:238011 16/35 (46%)
EGF_CA 830..865 CDD:238011 15/34 (44%)
EGF_CA 868..905 CDD:238011 20/36 (56%)
EGF_CA 907..943 CDD:238011 17/35 (49%)
EGF_CA 1009..1045 CDD:238011 8/35 (23%)
EGF_CA 1047..1082 CDD:238011 13/35 (37%)
Laminin_G_1 1155..1290 CDD:395008 0/134 (0%)
EGF 1316..1346 CDD:394967 11/29 (38%)
Laminin_G_1 1388..1550 CDD:395008 2/161 (1%)
EGF_CA <1593..1622 CDD:238011 10/28 (36%)
Laminin_G_2 1692..1828 CDD:460494 11/135 (8%)
EGF_CA 1901..1937 CDD:238011 14/35 (40%)
EGF_CA 1939..1974 CDD:238011 14/36 (39%)
EGF_CA 2057..2094 CDD:238011 12/50 (24%)
EGF_CA 2096..2133 CDD:238011 12/58 (21%)
EGF_CA 2137..2175 CDD:238011 9/49 (18%)
Blue background indicates that the domain is not in the aligned region.

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