DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NOTCH4 and Dl

DIOPT Version :9

Sequence 1:	NP_004548.3	Gene:	NOTCH4 / 4855	HGNCID:	7884	Length:	2003	Species:	Homo sapiens
Sequence 2:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster

Alignment Length:	476	Identity:	154/476 - (32%)
Similarity:	212/476 - (44%)	Gaps:	81/476 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   573 FHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPK 637
            |...|...:.|..|   ...|.......|.|.....|...||  :|:.|..|.:|.||..
  Fly   180 FRVTCDLNYYGSGC---AKFCRPRDDSFGHSTCSETGEIICL--TGWQGDYCHIPKCAKG----- 234

Human   638 QICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQR-SSCVCDVGWTGPECEAELGGCISAP-C 700
                                         |.||||.: :.|||.:||.|..|..    |:..| |
  Fly   235 -----------------------------CEHGHCDKPNQCVCQLGWKGALCNE----CVLEPNC 266

Human   701 AHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTAC-HSGPCLNGGSC-NPSPGGYYCTCPPSHTGPQ 763
            .| ||| .:|  :.|.|..|:.|..|::::..| :..||.|||:| |...|.|.|.|.|.::|..
  Fly   267 IH-GTC-NKP--WTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPGYSGDD 327

Human   764 CQTSTDYCVS--APCFNGGTCVNRPGT---FSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQD 823
            |:.....|.:  .||.|||||::.|.|   :.|.||.|:.|..||.|:. :|:|.|| ::..|::
  Fly   328 CENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVL-TCSDKPC-HQGICRN 390

Human   824 -------SPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNL 881
                   ..||.:|.||.||:|.:|...:|.|:..||.....|   .||..|:|..|::|..|..
  Fly   391 VRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSC---QPSGKCICPAGFSGTRCET 452

Human   882 PLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCM 946
            .:..|          :...|.|||.|:|....|.|.|.|||.|:.|...|:.|..|||.||.||:
  Fly   453 NIDDC----------LGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCL 507

Human   947 AQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECL 1011
            ...:.|.|.|..|:.|::||.::|.|.|.||||.|||..:...|.|.|..||.|.:|:.:..:.:
  Fly   508 NLNNDYQCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSV 572

Human  1012 DQPCHPTGT---AACHSLANA 1029
            ....|..|.   |....|.||
  Fly   573 TFDAHQYGATTQARADGLTNA 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NOTCH4	NP_004548.3	EGF_CA	194..232	CDD:238011
		EGF_CA	314..353	CDD:238011
		EGF_CA	432..473	CDD:238011
		EGF_CA	475..511	CDD:238011
		EGF_CA	515..549	CDD:238011
		EGF_CA	551..587	CDD:238011	3/13 (23%)
		EGF_CA	590..625	CDD:238011	8/34 (24%)
		EGF_CA	<699..726	CDD:238011	11/27 (41%)
		EGF_CA	<736..765	CDD:238011	13/29 (45%)
		EGF_CA	769..803	CDD:238011	15/38 (39%)
		EGF_CA	<899..928	CDD:238011	13/28 (46%)
		EGF_CA	931..965	CDD:238011	14/33 (42%)
		EGF_CA	970..1004	CDD:238011	16/33 (48%)
		Notch	1165..1203	CDD:321927
		LNR 1	1170..1213
		NL	1207..1245	CDD:197463
		LNR 2	1214..1250
		Notch	1249..1285	CDD:306554
		LNR 3	1251..1294
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1347..1371
		NODP	1380..>1420	CDD:311559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1485..1508
		ANK	1586..1721	CDD:238125
		ANK repeat	1586..1630	CDD:293786
		ANK 1	1633..1665
		ANK repeat	1634..1664	CDD:293786
		ANK	1661..1787	CDD:238125
		ANK repeat	1666..1698	CDD:293786
		ANK 2	1666..1698
		ANK 3	1700..1732
		ANK repeat	1700..1731	CDD:293786
		ANK 4	1733..1765
		ANK repeat	1733..1764	CDD:293786
		Ank_5	1753..>1851	CDD:330893
		ANK 5	1766..1798
		ANK repeat	1766..1797	CDD:293786
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1900..1927
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..2003
Dl	NP_001247193.1	MNNL	23..96	CDD:284966
		DSL	164..226	CDD:279722	12/50 (24%)
		EGF_CA	291..329	CDD:238011	14/37 (38%)
		EGF_CA	337..372	CDD:238011	14/34 (41%)
		EGF_CA	453..488	CDD:238011	14/44 (32%)
		EGF_CA	492..526	CDD:238011	14/33 (42%)
		EGF_CA	529..564	CDD:238011	16/34 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144844
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840