DRSC/TRiP Functional Genomics Resources

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Protein Alignment NOTCH4 and C901

DIOPT Version :10

Sequence 1:NP_004548.3 Gene:NOTCH4 / 4855 HGNCID:7884 Length:2003 Species:Homo sapiens
Sequence 2:NP_572673.1 Gene:C901 / 32032 FlyBaseID:FBgn0021742 Length:559 Species:Drosophila melanogaster


Alignment Length:331 Identity:98/331 - (29%)
Similarity:135/331 - (40%) Gaps:85/331 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   457 GSFNCLCPPGYTGSRCEAD--HNEC--LSQPC-HPGSTCLDLLATFHCLCPPGLEGQLCEVETNE 516
            |.|.||  ||:.|..|:..  ...|  ::..| .||          .|.|..|..|:||:    :
  Fly    66 GDFKCL--PGWQGDLCQVP
MCRRGCDPMNGYCQRPG----------ECRCRIGYSGELCD----K 114

Human   517 CASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGF 581
            |...|...|..|   ...|:|||.||::|..|.|  ..||:...:..|.| :.||  .|:|..|:
  Fly   115 CIPLPGCQHGGC---TKPFECICKPGWAGLFCTE--PSCRTGCHSTRGYC-EAPG--ECRCRIGY 171

Human   582 EGPRCQTEVDECLSDP-CPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKD 645
            .|..|    .||.:.| |..|.....|.    |||..|:||.||:.|:|.|              
  Fly   172 AGRTC----SECATMPGCQHGTCNKPLE----CLCLPGYTGLLCQTPICDP-------------- 214

Human   646 KANCLCPDGSPGCAPPEDNCTCHHGHCQR-SSCVCDVGWTGPECEAELGGCISAP-CAHGGTCYP 708
                              :|:..||:|:: ..|.|.|||||.:|:.    |...| ||:|....|
  Fly   215 ------------------DCSKQHGYCRKPGECRCKVGWTGSQCDK----CFPYPGCANGDCEAP 257

Human   709 QPSGYNCTCPTGYTGPTCSEEMTAC--HSGPCLNGGSC---NPSPGGYYCTCPPSHTGPQCQTST 768
                :.|.|..|:.|..|.|::|.|  |...|.|||.|   :...|.|.|.|.....|..|:...
  Fly   258 ----WECNCHPGWGGMLCDEKLTYCVEHPDTCENGGKCTSLSREDGSYQCQCRQGFLGKNCEIRD 318

Human   769 DYCVSA 774
            |:.:::
  Fly   319 DFLLTS 324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH4NP_004548.3 EGF_CA 194..225 CDD:429571
EGF 280..308 CDD:394967
EGF_CA 314..353 CDD:238011
EGF_CA <364..390 CDD:238011
EGF_CA 432..473 CDD:238011 7/15 (47%)
EGF_CA 475..511 CDD:238011 9/40 (23%)
EGF_CA 515..549 CDD:238011 11/33 (33%)
EGF_CA 551..587 CDD:238011 10/35 (29%)
EGF_CA 590..625 CDD:238011 13/35 (37%)
EGF_CA <699..726 CDD:238011 9/27 (33%)
EGF_CA <736..765 CDD:238011 10/31 (32%)
EGF_CA 769..803 CDD:238011 1/6 (17%)
EGF_CA <813..842 CDD:238011
EGF_CA <899..928 CDD:238011
EGF_CA 931..965 CDD:238011
EGF_CA 970..1004 CDD:238011
EGF_CA 1047..1084 CDD:238011
Notch 1168..1204 CDD:459658
LNR 1 1170..1213
Notch 1211..1246 CDD:459658
LNR 2 1214..1250
Notch 1249..1285 CDD:459658
LNR 3 1251..1294
NOD 1295..1344 CDD:462014
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1347..1371
NODP 1379..>1420 CDD:462229
JMTM_Notch4 1431..1515 CDD:411988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1485..1508
ANK repeat 1586..1630 CDD:293786
ANKYR <1619..1823 CDD:440430
ANK 1 1633..1665
ANK repeat 1634..1664 CDD:293786
ANK repeat 1666..1698 CDD:293786
ANK 2 1666..1698
ANK 3 1700..1732
ANK repeat 1700..1731 CDD:293786
ANK 4 1733..1765
ANK repeat 1733..1764 CDD:293786
ANK 5 1766..1798
ANK repeat 1766..1797 CDD:293786
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1900..1927
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..2003
C901NP_572673.1 DSL <56..82 CDD:473190 8/17 (47%)
EGF_CA 280..315 CDD:238011 11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

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