Protein Alignment NOTCH4 and set3

DIOPT Version :10

• Sequence 1: NP_004548.3
• Gene: NOTCH4 / 4855
• HGNCID: 7884
• Length: 2003
• Species: Homo sapiens
• Sequence 2: NP_594837.1
• Gene: set3 / 2541899
• PomBaseID: SPAC22E12.11C
• Length: 859
• Species: Schizosaccharomyces pombe
• Alignment Length: 540
• Identity: 104/540 - (19%)
• Similarity: 149/540 - (27%)
• Gaps: 234/540 - (43%)

Human   613 CLCP----SGFTGQL--CEV---PLC----APNL--------CQPKQICKDQKDKANCLCPDGSP 656
            |:||    .|||.|.  |||   .:|    |.|:        |||:.|..|:..|...
pombe     6 CVCPFEDDDGFTIQCESCEVWQHAVCVNIDANNVPEKYFCEQCQPRPIDADKAHKIQL------- 63

Human   657 GCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGG---TCYPQPSGYNCTCP 718
                         ...||              |.|....:|...:...   |.:    |.|...|
pombe    64 -------------ARLQR--------------EEEQSRILSRSRSSNNKRRTSF----GKNGASP 97

Human   719 TGYTGPTCSEEMTACHSGPCLNGG----SCNPSPGGYY------CTCPPSHT------------- 760
            |....|.......|       ||.    |.|.|..|.|      .|.|.:|.
pombe    98 THSASPRQGNNTGA-------NGALFSQSTNSSNSGSYRNSVTGATLPNAHAPHSQNRRRRSNHL 155

Human   761 -----GPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQG--------------PRCEGKL 806
                 .|..:.|.:|..|   |:.........|||. .|:.:..              ..|:  :
pombe   156 NNPPEAPITEASNEYVYS---FHLEYVPLESNTFSA-SALEYSKNLDLKNLDESEVLMDGCQ--V 214

Human   807 RPSCADSPCRNR----ATCQDSPQGPRCLCPTGYTGGSCQTLMD----LCAQ---KPCPRNSHCL 860
            .|..:...|.:|    :||:..|..|               :|:    :|.|   |..|:|.:.:
pombe   215 VPISSSKFCCSRFGLVSTCEIPPNTP---------------IMEVKGRVCTQNEYKSDPKNQYNI 264

Human   861 QTGPSFHC-------LCLQG-WTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCH 917
            ...|..|.       |.:.. ..|.........||..::     |||:..||.   :|.|.:..:
pombe   265 LGAPKPHVFFDSNSQLVVDSRVAGSKARFARKGCQSNSV-----VSSVYMNGS---NSVPRFILY 321

Human   918 CPPGFQGSLCQDHVNPCE----------SRPCQNGATCMAQP--------------SGYLC--QC 956
                     ...|:.|..          |.|.:..|..|::|              |.:|.  :|
pombe   322 ---------STTHIAPETEIIGDWTLDISHPFRQFAPGMSRPSFNMEELELLSEVLSTFLSFNEC 377

Human   957 APGYDGQNC-----SKELDACQSQPCHNHGT--------------CTPKPGGFHCACPPGFVGLR 1002
            | ..|.:||     :|.:.|.:.....|..:              .||.|.
pombe   378 A-SQDKKNCVFSRVTKYIKAARRASTANRVSVAKDRLSLTPSSTPSTPSPA-------------- 427

Human  1003 CEGDVDECLDQPCHPTGTAA 1022
                  |.|.||.:||...|
pombe   428 ------ESLPQPSNPTSVYA 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NOTCH4	NP_004548.3	EGF_CA	194..225	CDD:429571
		EGF	280..308	CDD:394967
		EGF_CA	314..353	CDD:238011
		EGF_CA	<364..390	CDD:238011
		EGF_CA	432..473	CDD:238011
		EGF_CA	475..511	CDD:238011
		EGF_CA	515..549	CDD:238011
		EGF_CA	551..587	CDD:238011
		EGF_CA	590..625	CDD:238011	7/17 (41%)
		EGF_CA	<699..726	CDD:238011	6/29 (21%)
		EGF_CA	<736..765	CDD:238011	11/56 (20%)
		EGF_CA	769..803	CDD:238011	7/47 (15%)
		EGF_CA	<813..842	CDD:238011	6/32 (19%)
		EGF_CA	<899..928	CDD:238011	5/28 (18%)
		EGF_CA	931..965	CDD:238011	11/59 (19%)
		EGF_CA	970..1004	CDD:238011	5/47 (11%)
		EGF_CA	1047..1084	CDD:238011
		Notch	1168..1204	CDD:459658
		LNR 1	1170..1213
		Notch	1211..1246	CDD:459658
		LNR 2	1214..1250
		Notch	1249..1285	CDD:459658
		LNR 3	1251..1294
		NOD	1295..1344	CDD:462014
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1347..1371
		NODP	1379..>1420	CDD:462229
		JMTM_Notch4	1431..1515	CDD:411988
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1485..1508
		ANK repeat	1586..1630	CDD:293786
		ANKYR	<1619..1823	CDD:440430
		ANK 1	1633..1665
		ANK repeat	1634..1664	CDD:293786
		ANK repeat	1666..1698	CDD:293786
		ANK 2	1666..1698
		ANK 3	1700..1732
		ANK repeat	1700..1731	CDD:293786
		ANK 4	1733..1765
		ANK repeat	1733..1764	CDD:293786
		ANK 5	1766..1798
		ANK repeat	1766..1797	CDD:293786
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1900..1927
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1968..2003
set3	NP_594837.1	PHD_MLL5	5..48	CDD:277025	13/41 (32%)
		SET_SpSET3-like	215..387	CDD:380960	40/204 (20%)