DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NOTCH4 and Notch4

DIOPT Version :10

Sequence 1:NP_004548.3 Gene:NOTCH4 / 4855 HGNCID:7884 Length:2003 Species:Homo sapiens
Sequence 2:XP_006523861.1 Gene:Notch4 / 18132 MGIID:107471 Length:1968 Species:Mus musculus


Alignment Length:2003 Identity:1608/2003 - (80%)
Similarity:1715/2003 - (85%) Gaps:49/2003 - (2%)


- Green bases have known domain annotations that are detailed below.


Human     1 MQPPSLLLLLLLLLLLCVSVVRPR----GLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGET 61
            |||.   |||||||.|...|:..|    .||||..|||||||||||.||.|||.|||||||||||
Mouse     1 MQPQ---LLLLLLLPLNFPVILTRVSSPELLCGGSPEPCANGGTCLRLSRGQGICQCAPGFLGET 62

Human    62 CQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSF 126
            |||||||::.|||:||||||||||.|....|..|||||.|.|||..||||:|||..||:.|||||
Mouse    63 CQFPDPCRDTQLCKNGGSCQALLPTPPSSRSPTSPLTPHFSCTCPSGFTGDRCQTHLEELCPPSF 127

Human   127 CSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHAC 191
            ||..|.|::||||||||||.|||||||||||||||||||.||||||||||||||.||||||||.|
Mouse   128 CSNGGHCYVQASGRPQCSCEPGWTGEQCQLRDFCSANPCANGGVCLATYPQIQCRCPPGFEGHTC 192

Human   192 ERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKD 256
            |||:||||.:|||||:||||||||||:|||||||||||:|:||.|.|||..|.|||||||:||..
Mouse   193 ERDINECFLEPGPCPQGTSCHNTLGSYQCLCPVGQEGPQCKLRKGACPPGSCLNGGTCQLVPEGH 257

Human   257 STFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQ 321
            ||||||||||||.|.|||:|||:||.||||||.||.|||||||||||:||.|||||||:||||.:
Mouse   258 STFHLCLCPPGFTGLDCEMNPDDCVRHQCQNGATCLDGLDTYTCLCPKTWKGWDCSEDIDECEAR 322

Human   322 GPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRT 386
            |||.|||||||||:||||||||||||||..||||||||.||||||||||||||||||||||||||
Mouse   323 GPPRCRNGGTCQNTAGSFHCVCVSGWGGAGCEENLDDCAAATCAPGSTCIDRVGSFSCLCPPGRT 387

Human   387 GLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGS 451
            ||||||||||||||||.:||||||||||||||:|||||||.|||||||||.||||||||||||||
Mouse   388 GLLCHLEDMCLSQPCHVNAQCSTNPLTGSTLCICQPGYSGSTCHQDLDECQMAQQGPSPCEHGGS 452

Human   452 CLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNE 516
            |:||||||||||.|||||||||||||||||||||||||||||||||||||||||||:|||||.||
Mouse   453 CINTPGSFNCLCLPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGRLCEVEVNE 517

Human   517 CASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGF 581
            |.|.||||.|.||||||||||:|||||:|.|||:|:|||.|:||||||:|:||||||:|:|||||
Mouse   518 CTSNPCLNQAACHDLLNGFQCLCLPGFTGARCEKDMDECSSTPCANGGRCRDQPGAFYCECLPGF 582

Human   582 EGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDK 646
            |||.|:.|||||||||||||||||||||||||||..||||||||||||.||:|||.|.|:.|:.:
Mouse   583 EGPHCEKEVDECLSDPCPVGASCLDLPGAFFCLCRPGFTGQLCEVPLCTPNMCQPGQQCQGQEHR 647

Human   647 ANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPS 711
            |.||||||||||.|.||||.|||||||||.||||.||||||||.|||||||.||||||||:||||
Mouse   648 APCLCPDGSPGCVPAEDNCPCHHGHCQRSLCVCDEGWTGPECETELGGCISTPCAHGGTCHPQPS 712

Human   712 GYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPC 776
            |||||||.||.|.|||||:||||||||||||||:..|.||.|||.|||||..|||:.|:||||.|
Mouse   713 GYNCTCPAGYMGLTCSEEVTACHSGPCLNGGSCSIRPEGYSCTCLPSHTGRHCQTAVDHCVSASC 777

Human   777 FNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSC 841
            .|||||||:||||.||||.||||..||.|..||||||||||:|||||:|:|.||||..||||.||
Mouse   778 LNGGTCVNKPGTFFCLCATGFQGLHCEEKTNPSCADSPCRNKATCQDTPRGARCLCSPGYTGSSC 842

Human   842 QTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGL 906
            |||:||||:||||..:.|||:||||.|||||||||.||:.|| ||||||:||||::|.||.||||
Mouse   843 QTLIDLCARKPCPHTARCLQSGPSFQCLCLQGWTGALCDFPL-SCQKAAMSQGIEISGLCQNGGL 906

Human   907 CVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDA 971
            |:|:|.||||.|||||||.||||:|||||..||.:|:||:.|||||:|||||||:||||||.|||
Mouse   907 CIDTGSSYFCRCPPGFQGKLCQDNVNPCEPNPCHHGSTCVPQPSGYVCQCAPGYEGQNCSKVLDA 971

Human   972 CQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLP 1036
            |||||||||||||.:||||||||||||||||||||||||||:||||:||||||||||||||||||
Mouse   972 CQSQPCHNHGTCTSRPGGFHCACPPGFVGLRCEGDVDECLDRPCHPSGTAACHSLANAFYCQCLP 1036

Human  1037 GHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGL 1101
            |||||.||||:|.|.||||.:||:||.|.|.|.||.||||||||||||||:|.|||.||||:|||
Mouse  1037 GHTGQRCEVEMDLCQSQPCSNGGSCEITTGPPPGFTCHCPKGFEGPTCSHKALSCGIHHCHNGGL 1101

Human  1102 CLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSP 1166
            ||||||||.||.||||||:|||||||||||.|||||||||:||:|:||.|||.|||:|:||..||
Mouse  1102 CLPSPKPGSPPLCACLSGFGGPDCLTPPAPPGCGPPSPCLHNGTCTETPGLGNPGFQCTCPPDSP 1166

Human  1167 GPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHP 1231
            |||||:|||.|||||.|||.||||||||||:||||||||||||||||||.||:||||||||:|||
Mouse  1167 GPRCQRPGASGCEGRGGDGTCDAGCSGPGGDWDGGDCSLGVPDPWKGCPPHSQCWLLFRDGRCHP 1231

Human  1232 QCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGPS 1296
            |||||||||||||||.|..|.|||||||.|||||||||||||.|||||||||||||..|.|..||
Mouse  1232 QCDSEECLFDGYDCEIPLTCIPAYDQYCRDHFHNGHCEKGCNNAECGWDGGDCRPEGEDSEGRPS 1296

Human  1297 LALLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPTYQE 1361
            |||||||.||||||||.|||||||||||||||||||.:||:||:||||.||:|:|.|.||.:..|
Mouse  1297 LALLVVLRPPALDQQLLALARVLSLTLRVGLWVRKDSEGRNMVFPYPGTRAKEELSGARDSSSWE 1361

Human  1362 RAAPQTQPLGKETDSLSAGFVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLP 1426
            |.||.||||||||:||.||||||||||||||||:|||||||||.|||||||||||||||||||||
Mouse  1362 RQAPPTQPLGKETESLGAGFVVVMGVDLSRCGPEHPASRCPWDSGLLLRFLAAMAAVGALEPLLP 1426

Human  1427 GPLLAVHPHAGTAPPANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRP 1491
            |||||.||.|||.|.|||||||:|||||.||:|||||||||||||||||||||||||||||.|||
Mouse  1427 GPLLAAHPQAGTRPSANQLPWPILCSPVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRP 1491

Human  1492 RTQSAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEGEEVGQAEETGPPSTCQLWSLSG 1556
            :||.||||||||||||:||||||||:||||||||.|||||||||    ||||...|.||||.|:.
Mouse  1492 QTQQAPHRRRPPLGEDNIGLKALKPEAEVDEDGVAMCSGPEEGE----AEETASASRCQLWPLNS 1552

Human  1557 GCGALPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTF---QGAWLGCPEPWEP 1618
            |||.||||||||||||.|.|..|:||.||||||||||||.||.|||.|.   |...||..|||||
Mouse  1553 GCGELPQAAMLTPPQECESEVLDVDTCGPDGVTPLMSAVFCGGVQSTTGASPQRLGLGNLEPWEP 1617

Human  1619 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVC 1683
            |||.||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||
Mouse  1618 LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVC 1682

Human  1684 QLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNAR 1748
            ||||.||||.||||||||||||||||||||||||||||||:||||||||.|||||||||||||||
Mouse  1683 QLLLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNAR 1747

Human  1749 AARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHW 1813
            ||||||||||||||||:||||||||||||||||||||||.|||||.|||||||||.|||.||:||
Mouse  1748 AARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHW 1812

Human  1814 DLLTLLEGAGPPEARHKATPGREAGPFPRARTVSVSVPPHGGGALPRCRTLSAGAGPRGGGACLQ 1878
            |||||||||||.....:|          .|||..      ||||.||||||||||.|||||||||
Mouse  1813 DLLTLLEGAGPTTQEARA----------HARTTP------GGGAAPRCRTLSAGARPRGGGACLQ 1861

Human  1879 ARTWSVDLAARGGGAYSHCRSLSGVGAGGGPTPRGRRFSAGMRGPRPNPAIMRGRYGVAAGRGGR 1943
            ||||||||.||||..|:.|||.|  |:.||||.||||||||.||                .||.|
Mouse  1862 ARTWSVDLGARGGKVYARCRSRS--GSCGGPTTRGRRFSAGSRG----------------RRGAR 1908

Human  1944 VSTDDWPCDWVALGACGSASNIPIPPPCLTPSPERGSPQLDCGPPALQEMPIN 1996
            .|.||||.|||||.|||||.:.|||||.|||||||||||:..|.|..||:|:|
Mouse  1909 ASQDDWPRDWVALEACGSACSAPIPPPSLTPSPERGSPQVAWGLPVHQEIPLN 1961

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH4NP_004548.3 EGF_CA 194..225 CDD:429571 25/30 (83%)
EGF 280..308 CDD:394967 23/27 (85%)
EGF_CA 314..353 CDD:238011 31/38 (82%)
EGF_CA <364..390 CDD:238011 25/25 (100%)
EGF_CA 432..473 CDD:238011 37/40 (93%)
EGF_CA 475..511 CDD:238011 34/35 (97%)
EGF_CA 515..549 CDD:238011 26/33 (79%)
EGF_CA 551..587 CDD:238011 27/35 (77%)
EGF_CA 590..625 CDD:238011 32/34 (94%)
EGF_CA <699..726 CDD:238011 22/26 (85%)
EGF_CA <736..765 CDD:238011 20/28 (71%)
EGF_CA 769..803 CDD:238011 25/33 (76%)
EGF_CA <813..842 CDD:238011 21/28 (75%)
EGF_CA <899..928 CDD:238011 21/28 (75%)
EGF_CA 931..965 CDD:238011 24/33 (73%)
EGF_CA 970..1004 CDD:238011 31/33 (94%)
EGF_CA 1047..1084 CDD:238011 25/36 (69%)
Notch 1168..1204 CDD:459658 30/35 (86%)
LNR 1 1170..1213 37/42 (88%)
Notch 1211..1246 CDD:459658 31/34 (91%)
LNR 2 1214..1250 31/35 (89%)
Notch 1249..1285 CDD:459658 30/35 (86%)
LNR 3 1251..1294 36/42 (86%)
NOD 1295..1344 CDD:462014 42/48 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1347..1371 13/23 (57%)
NODP 1379..>1420 CDD:462229 38/40 (95%)
JMTM_Notch4 1431..1515 CDD:411988 72/83 (87%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1485..1508 19/22 (86%)
ANK repeat 1586..1630 CDD:293786 33/46 (72%)
ANKYR <1619..1823 CDD:440430 191/203 (94%)
ANK 1 1633..1665 31/31 (100%)
ANK repeat 1634..1664 CDD:293786 29/29 (100%)
ANK repeat 1666..1698 CDD:293786 28/31 (90%)
ANK 2 1666..1698 28/31 (90%)
ANK 3 1700..1732 30/31 (97%)
ANK repeat 1700..1731 CDD:293786 29/30 (97%)
ANK 4 1733..1765 30/31 (97%)
ANK repeat 1733..1764 CDD:293786 29/30 (97%)
ANK 5 1766..1798 29/31 (94%)
ANK repeat 1766..1797 CDD:293786 28/30 (93%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1900..1927 16/26 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..2003 20/29 (69%)
Notch4XP_006523861.1 EGF_CA 162..193 CDD:238011 27/30 (90%)
EGF_CA 195..226 CDD:429571 25/30 (83%)
EGF_CA 315..354 CDD:238011 31/38 (82%)
EGF_CA 356..391 CDD:238011 33/34 (97%)
EGF_CA 433..474 CDD:238011 37/40 (93%)
EGF_CA 476..512 CDD:238011 34/35 (97%)
EGF_CA 515..550 CDD:238011 26/34 (76%)
EGF_CA 552..588 CDD:238011 27/35 (77%)
EGF_CA 591..626 CDD:238011 32/34 (94%)
EGF_CA <700..727 CDD:238011 22/26 (85%)
EGF_CA 769..804 CDD:238011 25/34 (74%)
EGF_CA <814..843 CDD:238011 21/28 (75%)
EGF_CA 896..928 CDD:238011 22/31 (71%)
EGF_CA 930..965 CDD:238011 24/34 (71%)
EGF_CA 970..1004 CDD:238011 31/33 (94%)
EGF_CA 1006..1044 CDD:238011 34/37 (92%)
Notch 1211..1246 CDD:459658 31/34 (91%)
Notch 1257..1285 CDD:459658 25/27 (93%)
NOD 1295..1344 CDD:462014 42/48 (88%)
NODP 1379..>1419 CDD:462229 37/39 (95%)
JMTM_Notch4 <1441..1515 CDD:411988 65/73 (89%)
ANK repeat 1582..1629 CDD:293786 33/46 (72%)
ANKYR <1618..1822 CDD:440430 191/203 (94%)
ANK repeat 1633..1663 CDD:293786 29/29 (100%)
ANK repeat 1665..1697 CDD:293786 28/31 (90%)
ANK repeat 1699..1730 CDD:293786 29/30 (97%)
ANK repeat 1732..1763 CDD:293786 29/30 (97%)
ANK repeat 1765..1796 CDD:293786 28/30 (93%)
ANK repeat 1798..1826 CDD:293786 23/27 (85%)

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