DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NOTCH4 and notch4

DIOPT Version :9

Sequence 1:NP_004548.3 Gene:NOTCH4 / 4855 HGNCID:7884 Length:2003 Species:Homo sapiens
Sequence 2:XP_031747113.1 Gene:notch4 / 100488695 XenbaseID:XB-GENE-22063929 Length:2106 Species:Xenopus tropicalis


Alignment Length:2272 Identity:877/2272 - (38%)
Similarity:1127/2272 - (49%) Gaps:498/2272 - (21%)


- Green bases have known domain annotations that are detailed below.


Human     7 LLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNA 71
            :|:.::.|.||      :||.|   ..||.|||.||||..|...|:|..   ||.|.:.|||.:.
 Frog     6 ILVPIIFLPLC------QGLDC---QIPCRNGGVCLSLENGTQICRCPD---GEDCTYRDPCLSV 58

Human    72 QLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQ 136
            | |:|||||...                        ..|..|||                     
 Frog    59 Q-CKNGGSCYRF------------------------SATDYRCQ--------------------- 77

Human   137 ASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQD 201
                    |..||||:.|:..|||:.|.|.|.|.|:...|..:|.||.||||.:||:||:|| |.
 Frog    78 --------CETGWTGKNCEYLDFCTPNRCKNNGKCINMVPSFRCQCPIGFEGESCEKDVDEC-QA 133

Human   202 PGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPP 266
            ...|..|.:|.|.:|||:|.||....|.|||:|.|.|....|.|.|.||.|   :...:.|:||.
 Frog   134 ADTCRNGGTCENLVGSFKCECPESYHGTRCEMRRGVCAADSCLNKGKCQQM---EFYKYQCVCPT 195

Human   267 GFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGT 331
            |:.|..||.|.|:|::|:|:|||:|:|||..|||.|...:.||.||.|:|||:|  |..|:||||
 Frog   196 GYTGSKCEENIDDCINHRCENGGSCKDGLGKYTCQCTPGFKGWYCSNDIDECQT--PAICKNGGT 258

Human   332 CQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMC 396
            |||..|.:.||||:||.|.:||.|:|||..||||.|:||||.||:|.|:|||||.||||..:|.|
 Frog   259 CQNIPGGYKCVCVNGWDGDNCEHNIDDCATATCAEGATCIDHVGTFLCMCPPGRIGLLCTTQDGC 323

Human   397 LSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNC 461
            ::.|||.:|.|.:. ||...||.|||||:|||||||||||   |.|.|||||||.|:||||||.|
 Frog   324 VNNPCHPEATCDSQ-LTSVALCRCQPGYTGPTCHQDLDEC---QLGSSPCEHGGQCVNTPGSFYC 384

Human   462 LCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHA 526
            .||.|:||:|||....||...|||..:||||||..|.|||.||.:|:.||:|.:||.|:||.|..
 Frog   385 SCPRGFTGARCETVQAECQPNPCHNKATCLDLLGHFECLCVPGYKGERCELEIDECQSSPCQNGG 449

Human   527 DCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVD 591
            .|.||||.:.|.|..|:.|.:||:|:|||.||||.|||||.:|||:::|.|..||:|..|:|:::
 Frog   450 SCTDLLNDYICSCPQGYQGPQCEDDVDECSSSPCKNGGQCHNQPGSYNCSCPGGFQGSVCETDIN 514

Human   592 ECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLC--EVPLCAPNLCQPKQICKDQKDKANCLCPDG 654
            ||.|.||..| ||.|.||.|.|.|..|:||.:|  |:.:|....|.....|:.:|:...|:|..|
 Frog   515 ECASSPCHFG-SCEDNPGFFTCHCDPGYTGTVCEKEIDVCESQPCHFGAQCQARKNGFMCICQPG 578

Human   655 SPG----------------------------------------CAPPEDNC---TCHHGHCQ--- 673
            :.|                                        |...::||   ||.||:||   
 Frog   579 TTGTLCDEDINECHSSPCLNGGACNNTQGGFLCHCPPGTIQPLCTLQDNNCTNVTCVHGNCQKQN 643

Human   674 -RSSCVCDVGW-------------------------------------TGPECEAELGGCISAPC 700
             |::|:||.||                                     |||.||..|..|.|.||
 Frog   644 NRTTCICDEGWKGSVCDTYIQCVTNPCQNGGVCQPFQERFICSCVSGYTGPNCETLLSPCYSNPC 708

Human   701 AHGGTC--YPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQ 763
            ::||||  ||..:...|.||.|:.|.:|..::..|...||.|||.|..:||.::|.|.|.:||..
 Frog   709 SNGGTCHHYPDQNVIQCDCPAGWQGSSCELDVNECEKRPCKNGGRCVNTPGAHHCICLPDYTGTL 773

Human   764 CQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDS---- 824
            |:...|.|:|..|.||||||:.  ||||||..|:.|..||..: ..|..|||:|.|:||:.    
 Frog   774 CEALVDPCLSDKCQNGGTCVSE--TFSCLCPAGYTGEHCEEDI-DECVSSPCQNGASCQNKANSY 835

Human   825 ----------------------------------------------------------------- 824
                                                                             
 Frog   836 ICVCDEGYEGEKCEINTMDCTTSSCLNGGTCVDGIASFWCLCPERFTGKHCQEELSRCLSNPCTN 900

Human   825 -------PQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLP 882
                   |.|..|.||.||||.:|:..:|.|:..||.....|.|:|.|:.|.|..||.|..|..|
 Frog   901 RGICQHIPGGYFCSCPYGYTGANCEMAVDFCSTAPCQNGGSCSQSGISYKCHCASGWIGSHCETP 965

Human   883 LSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMA 947
            |..| :|.:||.::.::||:..|.|||||.||.|||.||:.||||:.....|:..||||||.|..
 Frog   966 LHGC-RARVSQDVETTALCNGHGTCVDSGHSYICHCFPGYTGSLCEVKTGFCQPNPCQNGAHCQE 1029

Human   948 QPSGYLCQCAPGYDGQNCSKELDACQSQPC-HN-------------------------------- 979
            |...:||||.||:.||.|: |.|.|.|:|| ||                                
 Frog  1030 QDGSFLCQCLPGFLGQTCT-ERDPCLSRPCFHNGVCVAQGGEYKCQCPSGTQGIHCEINPDDCAT 1093

Human   980 --------H-GTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCL 1035
                    | |||..:.|||.|.|||||||.||||||:|||..||||.||..|..|.||:.|:|.
 Frog  1094 VSSEPKCFHGGTCRDEIGGFSCFCPPGFVGRRCEGDVNECLSNPCHPIGTEICVQLNNAYKCKCH 1158

Human  1036 PGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGG 1100
            ..:|||.|:..|:.|.:.|||:||:|..||.:||||.|.|||||.|.|||.....|..|.|::||
 Frog  1159 RLYTGQKCDQPINFCANNPCFNGGSCAVTANTPLGFTCSCPKGFSGATCSEPILPCSPHTCNNGG 1223

Human  1101 LCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSS 1165
            .|:......:  .|.|.:||.||.||....|          |..|.|                ||
 Frog  1224 KCVSDTNGRY--YCHCSNGYSGPHCLESIMP----------YTASAS----------------SS 1260

Human  1166 PGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCH 1230
            |..                                      :|:|...|| :..|..:|::|.|.
 Frog  1261 PPV--------------------------------------LPEPSNRCP-YIDCKKVFKNGVCD 1286

Human  1231 PQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGP 1295
            ..|::|:||:||:||....||.|.|:.||.|||.|||||:||:..|||||||||..|:.....| 
 Frog  1287 KHCNNEQCLYDGFDCNATQACNPLYNNYCLDHFANGHCERGCDNVECGWDGGDCSNEERKKSEG- 1350

Human  1296 SLALLVVLSPPALDQ-QLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPTY 1359
            ||.|::..:||.|.| ::.||.|.||:.:|.|:.::||..| :|::.|   |..:.|    |..:
 Frog  1351 SLILVLSYAPPVLHQREINALLRNLSMLIRAGIRLQKDSSG-NMLFRY---RRSDSL----DELF 1407

Human  1360 QERAA---------PQTQPLGKET----DSLSAG-FVVVMGVDLSRCGPDHPASRCPWDPGL--- 1407
            .:|..         |..:.|.|||    |::... |:.|.|.:            |...|.|   
 Frog  1408 PDRLQRWEYEVIENPNLKDLKKETMSREDTIGCVLFLEVFGAE------------CVQPPCLHTS 1460

Human  1408 --LLRFLAAMAAVGALEPLLPGPLLAVH----PHAGTAPPANQLPWPVLCSPVAGVILLALGALL 1466
              :..|:.|::.  ..||.||..||.|.    |...|...|.|||||::.:.||....|.||..:
 Frog  1461 KNVADFVTALSE--KTEPCLPYSLLGVKYKDAPIDPTQMSATQLPWPLVWASVAVGAALVLGGFI 1523

Human  1467 VLQLIRRRRREHGALWLPPGFTRRPRTQSAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGP 1531
            .:||  .|:|:||.||||.||:|....:..  |||.|:|||:.||:.||..:..|.|...     
 Frog  1524 GVQL--SRKRQHGVLWLPSGFSRHRSGEGI--RRREPVGEDATGLRPLKHDSVYDVDLAT----- 1579

Human  1532 EEGEEVGQA--EETGPPSTCQL-----WS---LSGGCGALPQAAMLTPPQESEMEAPDLDTRGPD 1586
              .||:.|.  :....|..|.:     ||   :..|. ..||...|||||: |.:..|:|.||||
 Frog  1580 --DEEILQPKYKRAKVPEECSILDHRQWSQQHIDAGV-RFPQCIALTPPQQ-EADCRDIDVRGPD 1640

Human  1587 GVTPLMSAVCCGEVQSGTFQGAWLGCPEP--------WEPLLDGGACPQAHTVGTGETPLHLAAR 1643
            ||||||||:|.|    |..:.|..|...|        ...|:..||...|.|..||||.||||||
 Frog  1641 GVTPLMSAICAG----GGLEPAGGGADPPEVESSAVVISDLISQGASLNAQTDSTGETALHLAAR 1701

Human  1644 FSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLA 1708
            |||..|.:.:|:|||:.|..|:.||||||.|:||||..|.|.|||.|||.:|||..||:|||:||
 Frog  1702 FSRQDAVKCMLDAGADTNVQDKLGRTPLHTAIAADALGVFQTLLRCRQTDIDARMNDGSTPLILA 1766

Human  1709 ARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFL 1773
            |||.|:::||||::..||:||.|..||:|||||||||||.|.::||..||:||.||.|::|||||
 Frog  1767 ARLPVQNMVEELVSCGADLGAADTRGKSALHWAAAVNNAAAVKTLLCNGANKDLQDKRDETPLFL 1831

Human  1774 AAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGP--PEARHKATP--G 1834
            |||||::|..::||...|.|:|.|..|..|..:|..|.|.|:..|||...|  |.....|||  |
 Frog  1832 AAREGSLEATRILLEHQADRDLCDHTGRQPRHIARDRGHRDIQKLLEERCPAVPRNTSVATPSAG 1896

Human  1835 REAGPFPRART---VSVSVPPH---GGGALPRCRTLSAG---AGPRGGGACLQARTWSVDLAARG 1890
            .:|....|.||   |..:..||   .....|:...|||.   .||....:|.|            
 Frog  1897 AQAKKTHRPRTKEHVKPTPLPHIDLSTSCYPQAPPLSAPPYIQGPPPDSSCCQ------------ 1949

Human  1891 GGAYSHCRSLSGVGAGGGPTPRGRRFSA-------GMRGPRPN--PA---IMRGRYGVAAGRGGR 1943
                || .||...|....|.||...||:       |.||.|.:  |:   :....|   :|.|..
 Frog  1950 ----SH-HSLMSYGGNCQPYPRSGSFSSAVPGCQWGNRGWRVHFCPSGCTVSEAPY---SGGGQP 2006

Human  1944 VSTD-DW----------PCDWVALGACGSAS---NIPIPPPCLTPSPERGSPQLDCGPPALQ 1991
            ||.. .|          .|.....|.|.:::   ..|...|| ||:.:.|: .:...||:.|
 Frog  2007 VSPHAHWLPESHHPQSPKCQSQPSGYCPNSALEQTAPKDLPC-TPTDQFGN-SIYLTPPSSQ 2066

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH4NP_004548.3 EGF_CA 194..232 CDD:238011 17/37 (46%)
EGF_CA 314..353 CDD:238011 22/38 (58%)
EGF_CA 432..473 CDD:238011 28/40 (70%)
EGF_CA 475..511 CDD:238011 18/35 (51%)
EGF_CA 515..549 CDD:238011 15/33 (45%)
EGF_CA 551..587 CDD:238011 21/35 (60%)
EGF_CA 590..625 CDD:238011 18/36 (50%)
EGF_CA <699..726 CDD:238011 13/28 (46%)
EGF_CA <736..765 CDD:238011 13/28 (46%)
EGF_CA 769..803 CDD:238011 18/33 (55%)
EGF_CA <899..928 CDD:238011 18/28 (64%)
EGF_CA 931..965 CDD:238011 17/33 (52%)
EGF_CA 970..1004 CDD:238011 23/75 (31%)
Notch 1165..1203 CDD:321927 2/37 (5%)
LNR 1 1170..1213 2/42 (5%)
NL 1207..1245 CDD:197463 14/37 (38%)
LNR 2 1214..1250 14/35 (40%)
Notch 1249..1285 CDD:306554 24/35 (69%)
LNR 3 1251..1294 25/42 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1347..1371 4/32 (13%)
NODP 1380..>1420 CDD:311559 8/45 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1485..1508 9/22 (41%)
ANK 1586..1721 CDD:238125 76/142 (54%)
ANK repeat 1586..1630 CDD:293786 19/51 (37%)
ANK 1 1633..1665 19/31 (61%)
ANK repeat 1634..1664 CDD:293786 18/29 (62%)
ANK 1661..1787 CDD:238125 78/125 (62%)
ANK repeat 1666..1698 CDD:293786 21/31 (68%)
ANK 2 1666..1698 21/31 (68%)
ANK 3 1700..1732 19/31 (61%)
ANK repeat 1700..1731 CDD:293786 19/30 (63%)
ANK 4 1733..1765 21/31 (68%)
ANK repeat 1733..1764 CDD:293786 20/30 (67%)
Ank_5 1753..>1851 CDD:330893 46/104 (44%)
ANK 5 1766..1798 17/31 (55%)
ANK repeat 1766..1797 CDD:293786 17/30 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1900..1927 11/35 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..2003 8/24 (33%)
notch4XP_031747113.1 EGF_CA 94..125 CDD:238011 13/30 (43%)
EGF_CA 127..164 CDD:238011 17/37 (46%)
EGF_CA 205..240 CDD:238011 18/34 (53%)
EGF_CA 243..280 CDD:238011 22/38 (58%)
EGF_CA 282..318 CDD:238011 25/35 (71%)
EGF_CA 358..396 CDD:238011 28/40 (70%)
EGF_CA 401..434 CDD:238011 18/32 (56%)
EGF_CA 437..472 CDD:238011 15/34 (44%)
EGF_CA 474..510 CDD:238011 21/35 (60%)
EGF_CA 512..547 CDD:238011 17/35 (49%)
EGF_CA 587..>616 CDD:214542 0/28 (0%)
EGF_CA <668..697 CDD:238011 3/28 (11%)
EGF_CA 739..775 CDD:238011 14/35 (40%)
EGF_CA 778..811 CDD:238011 18/34 (53%)
EGF_CA 813..849 CDD:238011 8/36 (22%)
EGF_CA <860..887 CDD:238011 0/26 (0%)
EGF_CA <896..925 CDD:238011 9/28 (32%)
EGF_CA 928..963 CDD:238011 13/34 (38%)
EGF_CA 1017..1048 CDD:238011 16/30 (53%)
EGF_CA 1089..1127 CDD:238011 16/37 (43%)
EGF_CA 1170..1207 CDD:238011 21/36 (58%)
Notch 1275..1301 CDD:395019 10/25 (40%)
Notch 1311..1340 CDD:395019 20/28 (71%)
NOD 1349..1399 CDD:399654 20/54 (37%)
JMTM_Notch4 1478..1568 CDD:411988 40/93 (43%)
ANK repeat 1640..1689 CDD:293786 19/52 (37%)
PHA03095 1673..>1865 CDD:222980 109/191 (57%)
ANK repeat 1692..1722 CDD:293786 18/29 (62%)
Ank_2 1696..1789 CDD:403870 57/92 (62%)
ANK repeat 1724..1756 CDD:293786 21/31 (68%)
ANK repeat 1758..1789 CDD:293786 19/30 (63%)
ANK repeat 1791..1822 CDD:293786 20/30 (67%)
ANK repeat 1824..1855 CDD:293786 17/30 (57%)
DUF3454 2059..>2106 CDD:403221 3/8 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 72 1.000 Domainoid score I35846
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 1 1.000 - -
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D5821at33208
OrthoFinder 1 1.000 - - FOG0012084
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.010

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