DRSC/TRiP Functional Genomics Resources

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Protein Alignment NOTCH3 and notch3

DIOPT Version :10

Sequence 1:NP_000426.2 Gene:NOTCH3 / 4854 HGNCID:7883 Length:2321 Species:Homo sapiens
Sequence 2:NP_571624.2 Gene:notch3 / 58066 ZFINID:ZDB-GENE-000329-5 Length:2468 Species:Danio rerio


Alignment Length:2515 Identity:1419/2515 - (56%)
Similarity:1696/2515 - (67%) Gaps:306/2515 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    43 CLD-GSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSC 106
            |:| ..||.|||.|.     ::.|||.||::|..||..||||..||.....|:|.|.....:::|
Zfish    24 CVDTHRPCENGGMCI-----DSRCLCRPGYIGSLCQHLDPCHRSPCLNAAACKSQVANSIPQYTC 83

Human   107 RCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHG 171
            .|.|||||.||||.|.|.:||||:||||: ..:..:.|||||||||::||:|:||||....|.:|
Zfish    84 VCQRGFRGQDCSLVDACATSPCANGARCT-NWNNHYNCSCPPGYQGKNCRNDIDECRKPGKCLNG 147

Human   172 GTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVN 236
            |.|:||.|||||:|..||:|..||.|..|||||.|.|||||.|:||.||:|||||||.|.|||.|
Zfish   148 GICMNTHGSFRCECLTGYSGRTCEVPTQPCAPSQCLNGGTCHQTGDHTYECACLPGFRGHNCEDN 212

Human   237 VDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCV 301
            |||||||:|:|.|.|||||||||||||||||||:|.|||:||.:||||||||||||||:|||:||
Zfish   213 VDDCPGHKCMNNGICVDGVNTYNCQCPPEWTGQYCAEDVNECLMQPNACHNGGTCFNTIGGHTCV 277

Human   302 CVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAIC 366
            |||||||:.||:|||||||||||:|||||||||||:|.||:||||||||||||||||||:|.|:|
Zfish   278 CVNGWTGDDCSENIDDCATAVCFNGATCHDRVASFFCECPVGKTGLLCHLDDACVSNPCNEGAVC 342

Human   367 DTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETD 431
            ||||:|||||||||.||.||||:||:||||||||||||.|:||||:|||.|||||||||||||.|
Zfish   343 DTNPLNGRAICTCPAGFVGGACNQDMDECSIGANPCEHFGKCVNTEGSFQCQCGRGYTGPRCEID 407

Human   432 VNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCP 496
            :|||||.||:|.||||||||:||||||.|:.|.|||||||||:|:||||.|:|:|.||||:|||.
Zfish   408 INECLSMPCQNDATCLDRIGEFTCICMPGYQGKYCEVDIDECESNPCVNDGICRDMVNGFTCTCQ 472

Human   497 SGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVD 561
            .||:|:.||:|:||||||||:|||||:|:|:||||||||||||.||:.|:|:|.|||||||.|||
Zfish   473 PGFTGTMCQIDIDECASTPCQNGAKCIDRPNGYECRCAEGFEGRLCESNIDNCKPDPCHHGTCVD 537

Human   562 GIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCAS 626
            ||||::|.|.|||||.|||:|::||.|.||::||||:|||:||:|:|..||:|.|||:|.|||||
Zfish   538 GIASYTCNCEPGYTGYRCENQLNECHSNPCQNGGKCVDLVNKYICQCQHGTSGTNCEINFDDCAS 602

Human   627 NPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPL 691
            |||.:|:|:||||||:|||:||||||.|..||:||.|:||..||:|||.||||.|.||.|...|.
Zfish   603 NPCDYGICKDGINRYECVCKPGFTGPQCKDEIDECQSNPCRNGGTCVDDENGFHCQCPEGFHDPY 667

Human   692 CLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGF 756
            |......||..||.||.|.|.|.|:||.|||||.|..|  .|.|:.|...||:..|||.....||
Zfish   668 CYSQVDECASNPCLHGTCRDDPNGYRCDCEPGWVGKNC--DLDRNDCLPSPCQNAGTCFDQLNGF 730

Human   757 HCTCPPGVQGRQC---------------------------------------ELLSPCTPNPCEH 782
            .|.|..|.:|..|                                       |||:||:||||.:
Zfish   731 TCKCRQGFRGNLCQVNINECASSPCLNQGTCVDGVASFTCLCEPPYSGPTCAELLTPCSPNPCAN 795

Human   783 GGRCESAPGQLPV-CSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSC 846
            ...|...|..|.. |:|..||||..|..|::||.. .||...|.|||..|.:.|:|..|||||:|
Zfish   796 HASCVHTPDYLGYQCNCQPGWQGHLCNNDINECTS-NPCKNRGTCTNTLGGYVCSCRAGYTGPNC 859

Human   847 DQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPC-GPGTCTDHVASFTC 910
            :.|||||.||||||||||.|||.||.|||||||.|.|||.:::||.|.|| ..|||||:|.|:||
Zfish   860 ETDINDCSPNPCLNGGSCTDGVNSFRCSCLPGFTGARCATELNECQSVPCKNGGTCTDYVNSYTC 924

Human   911 TCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGG 975
            ||.||:.|..||.::|||:.|||||||||.||:|.|.|.||.|:||.:||:|.:.|.|:|||:||
Zfish   925 TCKPGFTGLLCETNVPDCTESSCFNGGTCTDGINGFKCTCRTGFTGDYCQYEVNECDSQPCLNGG 989

Human   976 VCSAAHPGFRCTCLESFTGPQCQTLVDWC-SRQPCQNGGRCVQTGA--YCLCPPGWSGRLCDIRS 1037
            :|..|...:||:|.:.:|||:||..|||| ...||:|||||.|..|  .|.|..|||||.|||..
Zfish   990 ICQDAMESYRCSCPKGYTGPRCQYPVDWCRPSNPCKNGGRCRQKDASFTCDCLGGWSGRYCDIPG 1054

Human  1038 LPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGY 1102
            :.|..||.|.|.:.::||..||.||:..::|||.||...|||:||.:.|.|..:||.:|.|||.|
Zfish  1055 VSCEVAARQRGRQTDELCLHGGHCVNTGNTHYCKCPADYTGSYCESQFDHCEEKPCLNGATCRSY 1119

Human  1103 MGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPG 1167
            |||:.|:|:|||.|:|||.:|:||.|.|||:||:|||||..|:|||||||||||||||||||.. 
Zfish  1120 MGGFTCDCMPGYEGNNCEREVNECQSHPCQNGGTCIDLVGHYICSCPPGTLGVLCEINEDDCAT- 1183

Human  1168 PPLDSG-PRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFR 1231
            |....| |:|.:||||||.|||:||.||||:||.|||.|||||.|..|:.:::.||:|.| ..::
Zfish  1184 PSWPRGMPKCQNNGTCVDRVGGYRCNCPPGFTGERCEGDINECLSNPCNPSNSLDCIQLP-NDYQ 1247

Human  1232 CLCHAGFSGPRCQTVLSPCESQPCQHGGQCR---PSPGPGGGLTFTCHCAQPFWGPRCERVARSC 1293
            |:|..||:|..||:..|.||||||::||.|.   .|| ||    ::|.|...:.|..||| :.:|
Zfish  1248 CVCKPGFTGRGCQSRFSVCESQPCKNGGVCSLSGSSP-PG----YSCTCQLGYAGSNCER-SMNC 1306

Human  1294 RELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPF 1358
            :||.|..|..|..|.||.||.|..|..||.|:.       .||..|::.||.:||.|......||
Zfish  1307 KELPCYNGGSCTLTTRGARCTCIQGFGGPLCQH-------RSNDGCSSKPCHNGGLCTEETSYPF 1364

Human  1359 FRCACAQGWTGPRCE------APAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDC 1417
            |.|.|..||.|.|||      ||..:|       ||.|.|.:|..|..||:||||..|.||||||
Zfish  1365 FHCQCTNGWKGKRCEQKTGSSAPLPSP-------CPIADCFSKANDGVCDKECNSLDCRWDGGDC 1422

Human  1418 SLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADG 1482
            ||:| :||.:|...:||||||||:||..|::..||:|||||.  .:|:.|||:||.||.||:|||
Zfish  1423 SLAV-NPWARCADPRCWRLFNNSQCDEFCNNAECLFDNFDCI--NKEKVCNPIYEAYCTDHYADG 1484

Human  1483 RCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRL 1547
            .||||||||||||||||||.::|..||..:||:.||||||||||:...|||:|||||||:|||||
Zfish  1485 LCDQGCNTEECGWDGLDCARKIPEDLAEDMLVIVVLLPPEELLRTQTAFLQKLSAILRTTLRFRL 1549

Human  1548 DAHGQAMVFPYHRPSPGSEPRARRELAP-EVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYL 1611
            |.:|..|:.||    .|.|.|.:|||.| |||||:|.||||||||.|.  :|.||.:|.|||:||
Zfish  1550 DRNGDYMIRPY----TGRETRIKRELNPQEVIGSIVYLEIDNRLCSQG--SDDCFRNADSAAEYL 1608

Human  1612 GALSAVERLDFPYPLRDVRGEPLEPPEPSVP---LLPLLVAGAVLLLVILVLGVMVARRKREHST 1673
            |||||.|.|.||||:::|..|..||....:|   .|.|:...::.|||||::|:::|||||||||
Zfish  1609 GALSAREMLRFPYPIKEVTSEKREPSITEIPEWARLLLVGVASLFLLVILMVGMLIARRKREHST 1673

Human  1674 LWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAK--GESLMGEVATDWMDTECPEAKRLKVEE 1736
            |||||||.|.|:.:| :|.||||||||:||||:|.|  .|||:.:.:..|:||:|||||||||||
Zfish  1674 LWFPEGFFLKKETSS-NKNRREPVGQDSLGMKHMPKTVEESLLADHSDQWIDTDCPEAKRLKVEE 1737

Human  1737 PGM--GAEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFC 1799
            |.:  ..|:|||.||||||||.|||||:.|:||||||||:.|:|.||||||||||||||||||||
Zfish  1738 PSILSDGEDAVDSRQWTQHHLAAADIRMPPSMALTPPQGEFDSDCMDVNVRGPDGFTPLMLASFC 1802

Human  1800 GGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGAD 1864
            ||.|||..||:|::|::||:||||||.|||.|.|:||||||||||||||||||||||||||||||
Zfish  1803 GGGLEPEVTEDDDSDESSANIISDLIYQGASLAAQTDRTGETALHLAARYARADAAKRLLDAGAD 1867

Human  1865 TNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASH 1929
            .||||::||:|||.||.||||||||||||||:|||||||.||||||||||||||||||||||..|
Zfish  1868 ANAQDNTGRSPLHAAVAADAQGVFQILIRNRATDLDARMYDGSTALILAARLAVEGMVEELITCH 1932

Human  1930 ADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDH 1994
            ||||||||:|||||||||||||||||:|||||||||||||.||||||||||||||.||.|:||.|
Zfish  1933 ADVNAVDEIGKSALHWAAAVNNVEATIALLKNGANKDMQDLKEETPLFLAAREGSCEAVKVLLAH 1997

Human  1995 FANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSP----------PGPHGLGPLLCPPGAF 2049
            |||||||||:||||||:||||:|.|||:|||:.:..|||          .|.|.|.||:|||..|
Zfish  1998 FANREITDHMDRLPRDIAQERMHHDIVQLLDEYNTVRSPQGHAGAGHHLSGSHTLSPLMCPPSNF 2062

Human  2050 LPGLKAAQSGSKKSRRPPGKAGLGPQ-------GPRGRGKKLTLACPGPLADSSVTLSPVDSLDS 2107
            |.|||:...| ||:|| ||..|:|.|       ..:||.|:|||.....|.:|||||||||||||
Zfish  2063 LQGLKSTPQG-KKNRR-PGAKGIGGQHASGLKDSAKGRNKRLTLDMQSALLESSVTLSPVDSLDS 2125

Human  2108 PRPFGGP--------PASPGGFPLEGPYAAATAT-----------------AVSLAQLGGPGRAG 2147
            ||  ||.        |.||...|..|.:.::.:.                 :||||||...|..|
Zfish  2126 PR--GGASNAGYVTNPTSPAAMPSPGLFHSSMSVPNTPMVHSSILDSTSPFSVSLAQLSDLGDGG 2188

Human  2148 LGRQ----PPGGCV---------------LSLGLLNPVAVPLDW-ARLPP--------------- 2177
            |..|    ..||.|               ||:|:::||:||.|| .|:||               
Zfish  2189 LSMQGRVGMQGGGVNPGPHNYVMNAGQMSLSMGMVSPVSVPFDWHNRMPPSSQCSQPMISMVHPV 2253

Human  2178 ---------------------------------PAPP------GPSFLLPLA-PGPQ------LL 2196
                                             |.|.      .|..|.|:| ..||      |.
Zfish  2254 SSQAGMLPQTPTLQSSMLLHQQVFRNAQQPILQPTPVSSTPSISPVKLPPIAEQQPQQLHSHTLT 2318

Human  2197 NP-------GTPVSPQE-RPPPYL-----------------------AVPGHG------------ 2218
            ||       .||.:||: :|||..                       |:|...            
Zfish  2319 NPNLSRMATSTPPTPQQAQPPPAFYQPQQPQAQPPQAPTAPQATQAQAIPSQAPPAQVSGSTAGP 2383

Human  2219 EEYPA-------AGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATA 2276
            |:||.       :.|..:.|| .:|.||:|||||||||||||.|:||||..:||||:||||||..
Zfish  2384 EDYPTPPSQHSYSSAMDATPK-HYLHVPNEHPYLTPSPESPEPWSSPSPHCVSDWSDSTPSPAVT 2447

Human  2277 TGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA 2321
                                    |.:|||:....|...|.||.|
Zfish  2448 ------------------------APSQTQISQVQESNGKMQVFA 2468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH3NP_000426.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
EGF_CA 158..195 CDD:238011 20/36 (56%)
EGF_CA 236..272 CDD:238011 30/35 (86%)
EGF_CA 274..311 CDD:238011 30/36 (83%)
EGF_CA 314..349 CDD:238011 30/34 (88%)
EGF_CA 391..429 CDD:238011 32/37 (86%)
EGF_CA 431..467 CDD:238011 26/35 (74%)
EGF_CA 469..505 CDD:238011 23/35 (66%)
EGF_CA 507..542 CDD:238011 28/34 (82%)
EGF_CA 545..580 CDD:238011 25/34 (74%)
EGF_CA 583..618 CDD:238011 20/34 (59%)
EGF_CA 620..654 CDD:238011 26/33 (79%)
EGF_CA 657..>686 CDD:214542 19/28 (68%)
EGF_CA 810..846 CDD:238011 17/35 (49%)
EGF_CA 849..884 CDD:238011 28/34 (82%)
EGF_CA 887..922 CDD:238011 19/35 (54%)
EGF_CA 929..960 CDD:238011 19/30 (63%)
EGF_CA 1085..1120 CDD:238011 19/34 (56%)
EGF_CA 1122..1158 CDD:238011 26/35 (74%)
EGF_CA 1171..1203 CDD:238011 21/32 (66%)
Notch 1384..1418 CDD:459658 18/33 (55%)
LNR 1 1387..1427 24/39 (62%)
Notch 1425..1458 CDD:459658 18/32 (56%)
LNR 2 1428..1458 17/29 (59%)
LNR 3 1467..1505 30/37 (81%)
Notch 1474..1500 CDD:459658 22/25 (88%)
NOD 1505..1560 CDD:462014 35/54 (65%)
NODP 1577..1637 CDD:462229 37/59 (63%)
JMTM_Notch3 1618..1709 CDD:411987 52/93 (56%)
ANK repeat 1788..1836 CDD:293786 34/47 (72%)
ANKYR 1818..2043 CDD:440430 188/234 (80%)
ANK repeat 1838..1869 CDD:293786 29/30 (97%)
ANK 1 1838..1867 27/28 (96%)
ANK repeat 1871..1903 CDD:293786 26/31 (84%)
ANK 2 1871..1901 24/29 (83%)
ANK repeat 1905..1936 CDD:293786 28/30 (93%)
ANK 3 1905..1934 26/28 (93%)
ANK repeat 1938..1969 CDD:293786 28/30 (93%)
ANK 4 1938..1967 26/28 (93%)
ANK repeat 1971..2002 CDD:293786 26/30 (87%)
ANK 5 1971..2000 24/28 (86%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2024..2120 55/120 (46%)
PHA03247 <2045..2318 CDD:223021 134/435 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2190..2321 60/187 (32%)
notch3NP_571624.2 EGF_CA 97..131 CDD:238011 19/34 (56%)
EGF_CA 134..171 CDD:238011 20/36 (56%)
EGF_CA 212..247 CDD:238011 30/34 (88%)
EGF_CA 250..287 CDD:238011 30/36 (83%)
EGF_CA 290..325 CDD:238011 30/34 (88%)
EGF_CA 367..405 CDD:238011 32/37 (86%)
EGF_CA 407..443 CDD:238011 26/35 (74%)
EGF_CA 445..481 CDD:238011 23/35 (66%)
EGF_CA 483..519 CDD:238011 29/35 (83%)
EGF_CA 521..556 CDD:238011 25/34 (74%)
EGF_CA 560..594 CDD:238011 20/33 (61%)
EGF_CA 596..631 CDD:238011 26/34 (76%)
EGF_CA 634..668 CDD:238011 20/33 (61%)
EGF_CA 672..705 CDD:238011 18/32 (56%)
EGF_CA 708..744 CDD:238011 13/35 (37%)
EGF_CA 746..781 CDD:238011 0/34 (0%)
EGF_CA 824..860 CDD:238011 17/36 (47%)
EGF_CA 862..897 CDD:238011 28/34 (82%)
EGF_CA 902..936 CDD:238011 19/33 (58%)
EGF_CA 938..974 CDD:238011 22/35 (63%)
EGF_CA 977..1012 CDD:238011 15/34 (44%)
EGF_CA 1015..1050 CDD:238011 20/34 (59%)
EGF_CA 1067..1099 CDD:238011 14/31 (45%)
EGF_CA 1103..1137 CDD:238011 19/33 (58%)
EGF_CA 1140..1175 CDD:238011 26/34 (76%)
EGF_CA <1193..1220 CDD:238011 19/26 (73%)
EGF_CA 1222..1260 CDD:238011 16/38 (42%)
Notch 1392..1423 CDD:459658 18/30 (60%)
Notch 1429..1462 CDD:459658 18/32 (56%)
Notch 1475..1502 CDD:459658 22/26 (85%)
NOD 1507..1562 CDD:462014 35/58 (60%)
NODP 1576..1634 CDD:462229 37/59 (63%)
JMTM_Notch3 1615..1708 CDD:411987 52/93 (56%)
ANK repeat 1791..1839 CDD:293786 34/47 (72%)
ANKYR 1821..2031 CDD:440430 181/209 (87%)
ANK repeat 1841..1872 CDD:293786 29/30 (97%)
ANK repeat 1875..1906 CDD:293786 26/30 (87%)
ANK repeat 1908..1939 CDD:293786 28/30 (93%)
ANK repeat 1941..1972 CDD:293786 28/30 (93%)
ANK repeat 1974..2005 CDD:293786 26/30 (87%)
PHA03247 <2040..2412 CDD:223021 106/376 (28%)
Amelogenin 2232..2325 CDD:197891 15/92 (16%)
Blue background indicates that the domain is not in the aligned region.

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