| Sequence 1: | NP_000426.2 | Gene: | NOTCH3 / 4854 | HGNCID: | 7883 | Length: | 2321 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_064472.3 | Gene: | Notch3 / 56761 | RGDID: | 620761 | Length: | 2319 | Species: | Rattus norvegicus |
| Alignment Length: | 2324 | Identity: | 2124/2324 - (91%) |
|---|---|---|---|
| Similarity: | 2182/2324 - (93%) | Gaps: | 8/2324 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1 MGPGARGRRRRRRPMSPPPPPPPVRALP-LLLLLAGPGAAAPPCLDGSPCANGGRCT-QLPSREA 63
Human 64 ACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPC 128
Human 129 AHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPL 193
Human 194 CENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTY 258
Human 259 NCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVC 323
Human 324 FHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGAC 388
Human 389 DQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQF 453
Human 454 TCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRN 518
Human 519 GAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQV 583
Human 584 DECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPG 648
Human 649 FTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAP 713
Human 714 GGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPN 778
Human 779 PCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTG 843
Human 844 PSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASF 908
Human 909 TCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLH 973
Human 974 GGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSL 1038
Human 1039 PCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYM 1103
Human 1104 GGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGP 1168
Human 1169 PLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCL 1233
Human 1234 CHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQC 1298
Human 1299 PVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCAC 1363
Human 1364 AQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQC 1428
Human 1429 EALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEEC 1493
Human 1494 GWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPY 1558
Human 1559 HRPSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDFP 1623
Human 1624 YPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDVAS 1688
Human 1689 GHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKVEEPGMGAEEAVDCRQWTQH 1753
Human 1754 HLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSA 1818
Human 1819 SIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTAD 1883
Human 1884 AQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAA 1948
Human 1949 VNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQ 2013
Human 2014 ERLHQDIVRLLDQPSGPRSPPGPHGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPR 2078
Human 2079 GRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGP 2143
Human 2144 GRAG-LGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQER 2207
Human 2208 PPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPS 2272
Human 2273 PATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA 2321 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| NOTCH3 | NP_000426.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..26 | 20/24 (83%) | |
| EGF_CA | 158..195 | CDD:238011 | 27/36 (75%) | ||
| EGF_CA | 236..272 | CDD:238011 | 35/35 (100%) | ||
| EGF_CA | 274..311 | CDD:238011 | 35/36 (97%) | ||
| EGF_CA | 314..349 | CDD:238011 | 34/34 (100%) | ||
| EGF_CA | 391..429 | CDD:238011 | 37/37 (100%) | ||
| EGF_CA | 431..467 | CDD:238011 | 34/35 (97%) | ||
| EGF_CA | 469..505 | CDD:238011 | 35/35 (100%) | ||
| EGF_CA | 507..542 | CDD:238011 | 34/34 (100%) | ||
| EGF_CA | 545..580 | CDD:238011 | 33/34 (97%) | ||
| EGF_CA | 583..618 | CDD:238011 | 32/34 (94%) | ||
| EGF_CA | 620..654 | CDD:238011 | 33/33 (100%) | ||
| EGF_CA | 657..>686 | CDD:214542 | 27/28 (96%) | ||
| EGF_CA | 810..846 | CDD:238011 | 29/35 (83%) | ||
| EGF_CA | 849..884 | CDD:238011 | 32/34 (94%) | ||
| EGF_CA | 887..922 | CDD:238011 | 33/34 (97%) | ||
| EGF_CA | 929..960 | CDD:238011 | 29/30 (97%) | ||
| EGF_CA | 1085..1120 | CDD:238011 | 28/34 (82%) | ||
| EGF_CA | 1122..1158 | CDD:238011 | 33/35 (94%) | ||
| EGF_CA | 1171..1203 | CDD:238011 | 28/31 (90%) | ||
| Notch | 1384..1418 | CDD:459658 | 32/33 (97%) | ||
| LNR 1 | 1387..1427 | 36/39 (92%) | |||
| Notch | 1425..1458 | CDD:459658 | 32/32 (100%) | ||
| LNR 2 | 1428..1458 | 29/29 (100%) | |||
| LNR 3 | 1467..1505 | 36/37 (97%) | |||
| Notch | 1474..1500 | CDD:459658 | 25/25 (100%) | ||
| NOD | 1505..1560 | CDD:462014 | 53/54 (98%) | ||
| NODP | 1577..1637 | CDD:462229 | 57/59 (97%) | ||
| JMTM_Notch3 | 1618..1709 | CDD:411987 | 84/90 (93%) | ||
| ANK repeat | 1788..1836 | CDD:293786 | 46/47 (98%) | ||
| ANKYR | 1818..2043 | CDD:440430 | 223/224 (100%) | ||
| ANK repeat | 1838..1869 | CDD:293786 | 30/30 (100%) | ||
| ANK 1 | 1838..1867 | 28/28 (100%) | |||
| ANK repeat | 1871..1903 | CDD:293786 | 31/31 (100%) | ||
| ANK 2 | 1871..1901 | 29/29 (100%) | |||
| ANK repeat | 1905..1936 | CDD:293786 | 30/30 (100%) | ||
| ANK 3 | 1905..1934 | 28/28 (100%) | |||
| ANK repeat | 1938..1969 | CDD:293786 | 30/30 (100%) | ||
| ANK 4 | 1938..1967 | 28/28 (100%) | |||
| ANK repeat | 1971..2002 | CDD:293786 | 30/30 (100%) | ||
| ANK 5 | 1971..2000 | 28/28 (100%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2024..2120 | 90/95 (95%) | |||
| PHA03247 | <2045..2318 | CDD:223021 | 245/273 (90%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2190..2321 | 113/130 (87%) | |||
| Notch3 | NP_064472.3 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..20 | 15/18 (83%) | |
| EGF_CA | 160..197 | CDD:238011 | 27/36 (75%) | ||
| EGF_CA | 238..274 | CDD:238011 | 35/35 (100%) | ||
| EGF_CA | 276..313 | CDD:238011 | 35/36 (97%) | ||
| EGF_CA | 316..351 | CDD:238011 | 34/34 (100%) | ||
| EGF_CA | 393..431 | CDD:238011 | 37/37 (100%) | ||
| EGF_CA | 433..469 | CDD:238011 | 34/35 (97%) | ||
| EGF_CA | 471..507 | CDD:238011 | 35/35 (100%) | ||
| EGF_CA | 509..545 | CDD:238011 | 35/35 (100%) | ||
| EGF_CA | 547..582 | CDD:238011 | 33/34 (97%) | ||
| EGF_CA | 585..620 | CDD:238011 | 32/34 (94%) | ||
| EGF_CA | 622..656 | CDD:238011 | 33/33 (100%) | ||
| EGF_CA | 660..>688 | CDD:238011 | 26/27 (96%) | ||
| EGF_CA | 698..731 | CDD:238011 | 27/32 (84%) | ||
| EGF_CA | 738..772 | CDD:238011 | 27/33 (82%) | ||
| EGF_CA | 812..848 | CDD:238011 | 29/35 (83%) | ||
| EGF_CA | 851..886 | CDD:238011 | 32/34 (94%) | ||
| EGF_CA | 889..924 | CDD:238011 | 33/34 (97%) | ||
| EGF_CA | 931..962 | CDD:238011 | 29/30 (97%) | ||
| EGF_CA | 965..1000 | CDD:238011 | 23/34 (68%) | ||
| EGF_CA | 1087..1122 | CDD:238011 | 28/34 (82%) | ||
| EGF_CA | 1124..1160 | CDD:238011 | 33/35 (94%) | ||
| EGF_CA | 1173..1205 | CDD:238011 | 28/31 (90%) | ||
| NL | 1382..1419 | CDD:197463 | 34/36 (94%) | ||
| LNR 1 | 1389..1429 | 36/39 (92%) | |||
| NL | 1423..1460 | CDD:197463 | 35/36 (97%) | ||
| LNR 2 | 1430..1467 | 34/36 (94%) | |||
| LNR 3 | 1469..1507 | 36/37 (97%) | |||
| Notch | 1476..1502 | CDD:459658 | 25/25 (100%) | ||
| NOD | 1507..1562 | CDD:462014 | 53/54 (98%) | ||
| NODP | 1579..1639 | CDD:462229 | 57/59 (97%) | ||
| JMTM_Notch3 | 1620..1711 | CDD:411987 | 84/90 (93%) | ||
| ANK repeat | 1790..1838 | CDD:293786 | 46/47 (98%) | ||
| ANKYR | 1820..2028 | CDD:440430 | 207/207 (100%) | ||
| ANK repeat | 1840..1871 | CDD:293786 | 30/30 (100%) | ||
| ANK 1 | 1840..1869 | 28/28 (100%) | |||
| ANK repeat | 1873..1905 | CDD:293786 | 31/31 (100%) | ||
| ANK 2 | 1873..1903 | 29/29 (100%) | |||
| ANK repeat | 1907..1938 | CDD:293786 | 30/30 (100%) | ||
| ANK 3 | 1907..1936 | 28/28 (100%) | |||
| ANK repeat | 1940..1971 | CDD:293786 | 30/30 (100%) | ||
| ANK 4 | 1940..1969 | 28/28 (100%) | |||
| ANK repeat | 1973..2004 | CDD:293786 | 30/30 (100%) | ||
| ANK 5 | 1973..2002 | 28/28 (100%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2026..2046 | 18/19 (95%) | |||
| PHA03247 | <2029..2316 | CDD:223021 | 262/291 (90%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2059..2129 | 66/69 (96%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2197..2319 | 108/124 (87%) |