DRSC/TRiP Functional Genomics Resources

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Protein Alignment NOTCH3 and N

DIOPT Version :10

Sequence 1:NP_000426.2 Gene:NOTCH3 / 4854 HGNCID:7883 Length:2321 Species:Homo sapiens
Sequence 2:NP_476859.2 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster


Alignment Length:2754 Identity:1072/2754 - (38%)
Similarity:1394/2754 - (50%) Gaps:561/2754 - (20%)


- Green bases have known domain annotations that are detailed below.


Human     6 RGRRRRRRP----------MSPPPPPPPVRALPLLLL----------LAGPGAA--APPCLDGSP 48
            |.|||.|.|          |......|  .:||||||          :.|...|  |..|.... 
  Fly     5 RSRRRSRAPNTWICFWINKMHAVASLP--ASLPLLLLTLAFANLPNTVRGTDTALVAASCTSVG- 66

Human    49 CANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGF- 112
            |.|||.|....:.:..|.|...:||:.|:..:||:|..|...|.||.:...|....||:||.|| 
  Fly    67 CQNGGTCVTQLNGKTYCACDSHYVGDYCEHRNPCNSMRCQNGGTCQVTFRNGRPGISCKCPLGFD 131

Human   113 ---------------------------------------RGPDCSLPDPCLSSPCAHGARC-SVG 137
                                                   .|..|...:.|.||||.:||.| ::.
  Fly   132 ESLCEIAVPNACDHVTCLNGGTCQLKTLEEYTCACANGYTGERCETKNLCASSPCRNGATCTALA 196

Human   138 PDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCA 202
            ....|.||||||:.|.:|..|::||: ..||::||||:||.||::|.||.||||..|:....||:
  Fly   197 GSSSFTCSCPPGFTGDTCSYDIEECQ-SNPCKYGGTCVNTHGSYQCMCPTGYTGKDCDTKYKPCS 260

Human   203 PSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWT 267
            ||||:|||.||.:| |:|:|.|..||||:|||.|.|||.||.|.|||||:||::.|.|:|||.:|
  Fly   261 PSPCQNGGICRSNG-LSYECKCPKGFEGKNCEQNYDDCLGHLCQNGGTCIDGISDYTCRCPPNFT 324

Human   268 GQFCTEDVDEC-QLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHD 331
            |:||.:||||| |.....|.||.||.||.|.:||:|||||.|..||.|.|||..|.||:||||.|
  Fly   325 GRFCQDDVDECAQRDHPVCQNGATCTNTHGSYSCICVNGWAGLDCSNNTDDCKQAACFYGATCID 389

Human   332 RVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECS 396
            .|.||||.|..|||||||||||||.|||||.||||||:|:||...|:|..|:.|..|.:|:|||.
  Fly   390 GVGSFYCQCTKGKTGLLCHLDDACTSNPCHADAICDTSPINGSYACSCATGYKGVDCSEDIDECD 454

Human   397 IGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGF 461
            .| :||||.|.||||.||:.|.|.:|:|||||||::|||.|.||:|:.:|||..|.|.|:||.||
  Fly   455 QG-SPCEHNGICVNTPGSYRCNCSQGFTGPRCETNINECESHPCQNEGSCLDDPGTFRCVCMPGF 518

Human   462 TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQP 526
            |||.||:|||||||:||:|.|.|.|::|||.|:|..||:|:.||:::|:|.|.||||...|.|..
  Fly   519 TGTQCEIDIDECQSNPCLNDGTCHDKINGFKCSCALGFTGARCQINIDDCQSQPCRNRGICHDSI 583

Human   527 DGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPC 591
            .||.|.|..|:.||.|:.|::||..:|||.|:|:|.:.||.|.|.|||||..|:.|::||.|.||
  Fly   584 AGYSCECPPGYTGTSCEININDCDSNPCHRGKCIDDVNSFKCLCDPGYTGYICQKQINECESNPC 648

Human   592 RHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFG-VCRDGINRYDCVCQPGFTGPLCN 655
            :..|.|.|.|..|.|:|.:||:|.|||||:::|.||||..| .|.||||.|.|.|.|||||..|.
  Fly   649 QFDGHCQDRVGSYYCQCQAGTSGKNCEVNVNECHSNPCNNGATCIDGINSYKCQCVPGFTGQHCE 713

Human   656 VEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPC-SHGICYDAPGGFRCV 719
            ..::||.||||...|.|:|..||::|.||.|.....||.....||..|| :.|.|.|....|.|.
  Fly   714 KNVDECISSPCANNGVCIDQVNGYKCECPRGFYDAHCLSDVDECASNPCVNEGRCEDGINEFICH 778

Human   720 CEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHG 783
            |.||::|.||...:  |.|.|.||:.||||......|.|.|.||..|::||. :..|..|||.:|
  Fly   779 CPPGYTGKRCELDI--DECSSNPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCVTNPCGNG 841

Human   784 G--------------------------------RCESAPGQLP-------VCSCPQGWQGPRCQQ 809
            |                                ||::.....|       .|:|..|:.|..|.:
  Fly   842 GTCIDKVNGYKCVCKVPFTGRDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTGRYCDE 906

Human   810 DVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCS 874
            |:|||:..:||.....|.|:.||:.|.|..||.|..|..:.:||...||.|||:|.||:|.:||.
  Fly   907 DIDECSLSSPCRNGASCLNVPGSYRCLCTKGYEGRDCAINTDDCASFPCQNGGTCLDGIGDYSCL 971

Human   875 CLPGFAGPRCARDVDECLSNPCGPG-TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGT 938
            |:.||.|..|..|::||||.||..| ||:.:|.|:|||||.|:.|.:|:.:..||:.|||.|||:
  Fly   972 CVDGFDGKHCETDINECLSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESSCLNGGS 1036

Human   939 CVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDW 1003
            |:||:|.::|.|..||:||:||::.:.|.|.|||:|..|...:..:.|.|...|||.||...|||
  Fly  1037 CIDGINGYNCSCLAGYSGANCQYKLNKCDSNPCLNGATCHEQNNEYTCHCPSGFTGKQCSEYVDW 1101

Human  1004 CSRQPCQNGGRCVQTGAY--CLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDS 1066
            |.:.||:||..|.|....  |.|..||:|:|||::::.|::||.:.|:.|.|||. .|.|.|..:
  Fly  1102 CGQSPCENGATCSQMKHQFSCKCSAGWTGKLCDVQTISCQDAADRKGLSLRQLCN-NGTCKDYGN 1165

Human  1067 SHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPC 1131
            ||.|.|.:|..||:|::|:|.|.:||||:|||||..:|.|.|:|..|:.|.|||.::|:||..||
  Fly  1166 SHVCYCSQGYAGSYCQKEIDECQSQPCQNGGTCRDLIGAYECQCRQGFQGQNCELNIDDCAPNPC 1230

Human  1132 QHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPG 1196
            |:||:|.|.|..:.|||||||:|::||||:|||.||       .|.:||:|:|.||||.|.|.||
  Fly  1231 QNGGTCHDRVMNFSCSCPPGTMGIICEINKDDCKPG-------ACHNNGSCIDRVGGFECVCQPG 1288

Human  1197 YTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQC 1261
            :.|.|||.|||||.|..|..|.|.||:| ....:.|.|..|..|..|:..:..|...|||:||.|
  Fly  1289 FVGARCEGDINECLSNPCSNAGTLDCVQ-LVNNYHCNCRPGHMGRHCEHKVDFCAQSPCQNGGNC 1352

Human  1262 --RPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPR--GPRCACPPGLSGP 1322
              |.|       ...|.|...|:|..||...:.|....|.|| .|.....  |.||.||.|..|.
  Fly  1353 NIRQS-------GHHCICNNGFYGKNCELSGQDCDSNPCRVG-NCVVADEGFGYRCECPRGTLGE 1409

Human  1323 SCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEA-----PA------ 1376
            .|..       .:...|:..||..|.:|.  .|...:.|.|...|.|.||:.     |.      
  Fly  1410 HCEI-------DTLDECSPNPCAQGAACE--DLLGDYECLCPSKWKGKRCDIYDANYPGWNGGSG 1465

Human  1377 ------AAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWR 1435
                  ||....:...|.:..|..|:|:..||.:||:..|.:||.||||.: :||..|.|.:||.
  Fly  1466 SGNDRYAADLEQQRAMCDKRGCTEKQGNGICDSDCNTYACNFDGNDCSLGI-NPWANCTANECWN 1529

Human  1436 LFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDC 1500
            .|.|.:|:..|::.||.||..||..  :.::|:.:::.||..|:.||.||.|||..||.||||||
  Fly  1530 KFKNGKCNEECNNAACHYDGHDCER--KLKSCDSLFDAYCQKHYGDGFCDYGCNNAECSWDGLDC 1592

Human  1501 ASEVPA-LLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHRPSPG 1564
            .::..: :||.|.:.:.:|:..|......|.||:.:|.:|||::|.:.||.|..::..:      
  Fly  1593 ENKTQSPVLAEGAMSVVMLMNVEAFREIQAQFLRNMSHMLRTTVRLKKDALGHDIIINW------ 1651

Human  1565 SEPRARRELAPEV-------------------IGSVVMLEIDNRLCLQSPENDHCFPDAQSAADY 1610
             :...|   .||:                   .|..:.||||||.|.:      ||..|..||::
  Fly  1652 -KDNVR---VPEIEDTDFARKNKILYTQQVHQTGIQIYLEIDNRKCTE------CFTHAVEAAEF 1706

Human  1611 LGALSAVERLDFPYPLRDVRG-------EPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMV--AR 1666
            |.|.:|..:|...:.:..|||       :..|||..    :..::.|.:|:::.|....||  .:
  Fly  1707 LAATAAKHQLRNDFQIHSVRGIKNPGDEDNGEPPAN----VKYVITGIILVIIALAFFGMVLSTQ 1767

Human  1667 RKREHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGESL----MGEVATDWMDTE-- 1725
            |||.|...||||||.....|.|  :.||:|.||:   |:|:.|..::    :|:....|.|.|  
  Fly  1768 RKRAHGVTWFPEGFRAPAAVMS--RRRRDPHGQE---MRNLNKQVAMQSQGVGQPGAHWSDDESD 1827

Human  1726 CPEAKRLK---VEEPGMGAE-------------EAVDCRQWTQHHLVAADIRVAPAMALTPPQGD 1774
            .|..||.:   |...|:|..             |..|.|.|:|.||...|:|.    .:|||   
  Fly  1828 MPLPKRQRSDPVSGVGLGNNGGYASDHTMVSEYEEADQRVWSQAHLDVVDVRA----IMTPP--- 1885

Human  1775 ADADG--MDVNVRGPDGFTPLMLASFCGGALEPMPTEED--EADDTSASIISDLICQGAQLGART 1835
            |..||  .||:.|||.|.||||:|:..||.|:   |.||  ..:|::|.:||||:.|||:|.|..
  Fly  1886 AHQDGGKHDVDARGPCGLTPLMIAAVRGGGLD---TGEDIENNEDSTAQVISDLLAQGAELNATM 1947

Human  1836 DRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLD 1900
            |:||||:||||||:|||||||||||||||.|.||::||||||.||.|||.||||||:|||:|:|:
  Fly  1948 DKTGETSLHLAARFARADAAKRLLDAGADANCQDNTGRTPLHAAVAADAMGVFQILLRNRATNLN 2012

Human  1901 ARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANK 1965
            |||.||:|.||||||||:|||||:||.:.||:||.|..||:||||||||||.||...||.:.||:
  Fly  2013 ARMHDGTTPLILAARLAIEGMVEDLITADADINAADNSGKTALHWAAAVNNTEAVNILLMHHANR 2077

Human  1966 DMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQ--PS 2028
            |.||.|:|||||||||||||||.|.|||:|||||||||:||||||||.||||.|||||||:  |.
  Fly  2078 DAQDDKDETPLFLAAREGSYEACKALLDNFANREITDHMDRLPRDVASERLHHDIVRLLDEHVPR 2142

Human  2029 GPR------------SPPGP--------------------------------------------- 2036
            .|:            .|||.                                             
  Fly  2143 SPQMLSMTPQAMIGSPPPGQQQPQLITQPTVISAGNGGNNGNGNASGKQSNQTAKQKAAKKAKLI 2207

Human  2037 ---------------------------------HGLGPLL----------CPP------------ 2046
                                             :||.|..          .||            
  Fly  2208 EGSPDNGLDATGSLRRKASSKKTSAASKKAANLNGLNPGQLTGGVSGVPGVPPTNSAAQAAAAAA 2272

Human  2047 -------------------GAFLPG----------------------------------LKAAQS 2058
                               |..||.                                  :|.|||
  Fly  2273 AAVAAMSHELEGSPVGVGMGGNLPSPYDTSSMYSNAMAAPLANGNPNTGAKQPPSYEDCIKNAQS 2337

Human  2059 ---------------------GSKKSRR-----------------------PPGKAGLGPQGPRG 2079
                                 ||...:.                       |.|..|:|.....|
  Fly  2338 MQSLQGNGLDMIKLDNYAYSMGSPFQQELLNGQGLGMNGNGQRNGVGPGVLPGGLCGMGGLSGAG 2402

Human  2080 RGKKLTLACPGPLAD--------SSVTLSPVDSLDSPRPFGGPPASP------------------ 2118
            .|.........|.::        ||:.|||...|.||.|....|:.|                  
  Fly  2403 NGNSHEQGLSPPYSNQSPPHSVQSSLALSPHAYLGSPSPAKSRPSLPTSPTHIQAMRHATQQKQF 2467

Human  2119 GGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGP 2183
            ||..|......|....|  ...||.|..|:| |.|....:|||:::|....:.....||.:....
  Fly  2468 GGSNLNSLLGGANGGGV--VGGGGGGGGGVG-QGPQNSPVSLGIISPTGSDMGIMLAPPQSSKNS 2529

Human  2184 SFLLPLAPGPQL---------------------------------------LN-----PGTPVSP 2204
            :.:..::|..|.                                       ||     |.:..|.
  Fly  2530 AIMQTISPQQQQQQQQQQQQQHQQQQQQQQQQQQQQQQQLGGLEFGSAGLDLNGFCGSPDSFHSG 2594

Human  2205 QERPPPYL-----AVPGHGEEYPAAGAHSSPPKARFLRVPSEH--------------PYLTPSPE 2250
            |..||...     :.|......|:: .|:.....::|...|:|              .|.|||||
  Fly  2595 QMNPPSIQSSMSGSSPSTNMLSPSS-QHNQQAFYQYLTPSSQHSGGHTPQHLVQTLDSYPTPSPE 2658

Human  2251 SPEHWASPSPPSLSDWSESTPSPA 2274
            ||.||:|.||.|.|||||...|||
  Fly  2659 SPGHWSSSSPRSNSDWSEGVQSPA 2682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH3NP_000426.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 8/29 (28%)
EGF_CA 158..195 CDD:238011 20/36 (56%)
EGF_CA 236..272 CDD:238011 22/35 (63%)
EGF_CA 274..311 CDD:238011 22/37 (59%)
EGF_CA 314..349 CDD:238011 23/34 (68%)
EGF_CA 391..429 CDD:238011 23/37 (62%)
EGF_CA 431..467 CDD:238011 20/35 (57%)
EGF_CA 469..505 CDD:238011 21/35 (60%)
EGF_CA 507..542 CDD:238011 16/34 (47%)
EGF_CA 545..580 CDD:238011 18/34 (53%)
EGF_CA 583..618 CDD:238011 16/34 (47%)
EGF_CA 620..654 CDD:238011 20/34 (59%)
EGF_CA 657..>686 CDD:214542 14/28 (50%)
EGF_CA 810..846 CDD:238011 15/35 (43%)
EGF_CA 849..884 CDD:238011 17/34 (50%)
EGF_CA 887..922 CDD:238011 19/35 (54%)
EGF_CA 929..960 CDD:238011 16/30 (53%)
EGF_CA 1085..1120 CDD:238011 18/34 (53%)
EGF_CA 1122..1158 CDD:238011 19/35 (54%)
EGF_CA 1171..1203 CDD:238011 15/31 (48%)
Notch 1384..1418 CDD:459658 12/33 (36%)
LNR 1 1387..1427 17/39 (44%)
Notch 1425..1458 CDD:459658 13/32 (41%)
LNR 2 1428..1458 12/29 (41%)
LNR 3 1467..1505 19/37 (51%)
Notch 1474..1500 CDD:459658 16/25 (64%)
NOD 1505..1560 CDD:462014 16/55 (29%)
NODP 1577..1637 CDD:462229 21/85 (25%)
JMTM_Notch3 1618..1709 CDD:411987 31/99 (31%)
ANK repeat 1788..1836 CDD:293786 23/49 (47%)
ANKYR 1818..2043 CDD:440430 164/316 (52%)
ANK repeat 1838..1869 CDD:293786 26/30 (87%)
ANK 1 1838..1867 25/28 (89%)
ANK repeat 1871..1903 CDD:293786 23/31 (74%)
ANK 2 1871..1901 22/29 (76%)
ANK repeat 1905..1936 CDD:293786 22/30 (73%)
ANK 3 1905..1934 20/28 (71%)
ANK repeat 1938..1969 CDD:293786 19/30 (63%)
ANK 4 1938..1967 18/28 (64%)
ANK repeat 1971..2002 CDD:293786 26/30 (87%)
ANK 5 1971..2000 24/28 (86%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2024..2120 39/332 (12%)
PHA03247 <2045..2318 CDD:223021 84/428 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2190..2321 37/148 (25%)
NNP_476859.2 EGF_CA 179..214 CDD:238011 16/34 (47%)
EGF_CA 217..252 CDD:238011 20/35 (57%)
EGF_CA 260..291 CDD:238011 19/31 (61%)
EGF_CA 295..329 CDD:238011 21/33 (64%)
EGF_CA 331..369 CDD:238011 22/37 (59%)
EGF_CA 449..486 CDD:238011 23/37 (62%)
EGF_CA 488..524 CDD:238011 20/35 (57%)
EGF_CA 526..562 CDD:238011 21/35 (60%)
EGF_CA 564..600 CDD:238011 16/35 (46%)
EGF_CA 602..637 CDD:238011 18/34 (53%)
EGF_CA 640..675 CDD:238011 16/34 (47%)
EGF_CA 677..713 CDD:238011 20/35 (57%)
EGF_CA 715..750 CDD:238011 15/34 (44%)
EGF_CA 753..789 CDD:238011 14/35 (40%)
EGF_CA 791..827 CDD:238011 15/37 (41%)
EGF_CA 829..865 CDD:238011 6/35 (17%)
EGF_CA 907..943 CDD:238011 15/35 (43%)
EGF_CA 946..982 CDD:238011 17/35 (49%)
EGF_CA 984..1020 CDD:238011 19/35 (54%)
EGF_CA 1027..1058 CDD:238011 16/30 (53%)
EGF_CA 1062..1095 CDD:238011 12/32 (38%)
EGF_CA 1184..1219 CDD:238011 18/34 (53%)
EGF_CA 1221..1257 CDD:238011 19/35 (54%)
EGF_CA 1259..1295 CDD:238011 21/42 (50%)
EGF_CA 1297..1335 CDD:238011 16/38 (42%)
EGF_CA 1338..1373 CDD:238011 13/41 (32%)
EGF_CA 1417..1450 CDD:238011 10/34 (29%)
NL 1476..1512 CDD:197463 11/35 (31%)
Notch 1519..1553 CDD:459658 14/33 (42%)
Notch 1565..1593 CDD:459658 17/27 (63%)
NOD 1598..1652 CDD:462014 16/60 (27%)
NODP 1679..1731 CDD:462229 20/57 (35%)
JMTM_dNotch 1719..1806 CDD:411989 30/95 (32%)
ANK repeat 1902..1948 CDD:293786 23/48 (48%)
ANKYR 1936..2139 CDD:440430 152/202 (75%)
ANK repeat 1951..1981 CDD:293786 25/29 (86%)
ANK repeat 1984..2015 CDD:293786 23/30 (77%)
ANK repeat 2017..2048 CDD:293786 22/30 (73%)
ANK repeat 2050..2081 CDD:293786 19/30 (63%)
ANK repeat 2083..2114 CDD:293786 26/30 (87%)

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