DRSC/TRiP Functional Genomics Resources

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Protein Alignment NOTCH3 and glp-1

DIOPT Version :10

Sequence 1:NP_000426.2 Gene:NOTCH3 / 4854 HGNCID:7883 Length:2321 Species:Homo sapiens
Sequence 2:NP_499014.1 Gene:glp-1 / 176286 WormBaseID:WBGene00001609 Length:1295 Species:Caenorhabditis elegans


Alignment Length:1731 Identity:412/1731 - (23%)
Similarity:590/1731 - (34%) Gaps:599/1731 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   585 EC-RSQPCRHGGKCLD--LVDKYLCRCPSGTTGVNCEVNID-DC-ASNPCTFGVCRDGINRYDCV 644
            || |...|...|||.:  |::.|.|||..|..|..||...| || ....|.:.|..:...   |:
 Worm    22 ECGREGACSVNGKCYNGKLIETYWCRCKKGFGGAFCERECDLDCKRGEKCIYDVYGENPT---CI 83

Human   645 CQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGIC 709
            ||.      |..|......:..|    |.:|..|..|..|       .....:||..:||::|:|
 Worm    84 CQD------CEDETPPTERTQKG----CEEGYGGPDCKTP-------LFSGVNPCDSDPCNNGLC 131

Human   710 YDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSP 774
            |...|||:|:|..|:.|..|.:.:  |.|....|..|.||.:....::|.||.|..||.|| .:.
 Worm   132 YPFYGGFQCICNNGYGGSYCEEGI--DHCAQNECAEGSTCVNSVYNYYCDCPIGKSGRYCE-RTE 193

Human   775 CT--PNPCEHGGRCESAPGQLP--------VCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNL 829
            |.  .|.|.| |||      :|        .|.|..|::|..|.:|.:||.....|..:..|.||
 Worm   194 CALMGNICNH-GRC------IPNRDEDKNFRCVCDSGYEGEFCNKDKNECLIEETCVNNSTCFNL 251

Human   830 AGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSC-QDGVGSFSCSCLPGFAGPRCARDVDECLS 893
            .|.|:|||..||.|..|::.|:.|....|.|.|.| .|......|.|..||.|.||..:      
 Worm   252 HGDFTCTCKPGYAGKYCEEAIDMCKDYVCQNDGYCAHDSNQMPICYCEQGFTGQRCEIE------ 310

Human   894 NPCGPGTCTDHVASFTCTCPPGYGGFHCEQDL--PDCSPS--SCFNGGTCVDGVNSFSCLCRPGY 954
                              ||.|:||.||:..|  |.||.|  :|:|.|.|::|.    |:|.|.|
 Worm   311 ------------------CPSGFGGIHCDLPLQRPHCSRSNGTCYNDGRCINGF----CVCEPDY 353

Human   955 TGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTG 1019
            .|..|:      ::|                    :.|..|..|:    |...||.|...|:   
 Worm   354 IGDRCE------INR--------------------KDFKFPDIQS----CKYNPCVNNATCI--- 385

Human  1020 AYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQE 1084
                          |::                            :|.:.|.||.|..|.:|||.
 Worm   386 --------------DLK----------------------------NSGYSCHCPLGFYGLNCEQH 408

Human  1085 VDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCE-DDVDECASQPCQHGGSCIDLVARYLCSC 1148
            : .|....|.:||||.|..|...|.|..|::||.|| .|...|:..||::||.|.:         
 Worm   409 L-LCTPTTCANGGTCEGVNGVIRCNCPNGFSGDYCEIKDRQLCSRHPCKNGGVCKN--------- 463

Human  1149 PPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGA 1213
                                                          .||                
 Worm   464 ----------------------------------------------TGY---------------- 466

Human  1214 CHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCA 1278
                              |.|..|::||.|:.||...:|:                         
 Worm   467 ------------------CECQYGYTGPTCEEVLVIEKSK------------------------- 488

Human  1279 QPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAP 1343
            :......||:  |.|.:|                                     |||       
 Worm   489 ETVIRDLCEQ--RKCMDL-------------------------------------ASN------- 507

Human  1344 CLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSP 1408
                |.|.|                                                   |||..
 Worm   508 ----GICNP---------------------------------------------------ECNLE 517

Human  1409 GCGWDGGDCSLSVGD--PWRQCE-ALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPV 1470
            .|.:||||||   |.  |:.:|: ..:|...|.|..|:..|::..||||..||.:  ....|...
 Worm   518 ECNFDGGDCS---GGQRPFSKCQYPARCADQFANGVCNQECNNEECLYDGLDCQS--ELFRCPAH 577

Human  1471 YEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRL 1535
            ..|:|.:...||.|:..|:...||:||.||.:...|::...:.: .|.:.|.|...:..:.|.::
 Worm   578 IRKHCIERRGDGVCNLECSFIGCGFDGGDCNNGTEAIILSDIRI-KVQIDPIEFQATGGETLMQI 641

Human  1536 SAILRTSLRFRLDAHGQAMVFPY------HRPSPGSEP---------RARRELAPEVIGSVVMLE 1585
            ||.||.::|.:.|..| .:||.:      .|....|..         ..||.....|.|.|:.||
 Worm   642 SANLRATVRIQRDELG-PLVFRWDGEHEMERVEMNSSKLEDQFVLSHHVRRYRQAVVTGIVLYLE 705

Human  1586 IDNRLCLQSPENDHC-FPDAQSAADYL--GALSAVERLDFPYPLRDV------RGEPLEPPEPSV 1641
            :: .:|  .||  .| |..|||..|.:  |.:.:..|:....|:.:.      |.|..|....|.
 Worm   706 VE-EIC--KPE--FCRFSTAQSVVDLIAAGLVKSDGRMSLGLPITEAMVAVPKRNEIDEGWSRSQ 765

Human  1642 PLLPLLVAGAVLLLVILVLGVMVA------------RRKREHSTLWFPEGFSLHKDVASGHKGRR 1694
            .:|...:|       .|..|.:||            :||..::|:|.|...|      :..||||
 Worm   766 VILFACIA-------FLAFGTVVAGVIAKNGPERSRKRKMVNATVWMPPMES------TNEKGRR 817

Human  1695 EPVGQDALGMKNMAKGESLMGEVATDWMDTE--CPE--------------AKRLKVEEPGMGAEE 1743
                    ...|.:...||:...|....:|:  |.:              .:.|....||...|.
 Worm   818 --------NQSNHSSQCSLLDNSAYYHPNTKRHCSDYSTGYNGEQYSQIYPQTLANGYPGDYNEL 874

Human  1744 AVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVR--GPDGFT-PL------------ 1793
            ..|.:..|          .|||        |..||.:.::|:  |||..| |:            
 Worm   875 NFDFQSET----------FAPA--------DLPADEIPLHVQAAGPDAITAPITNESVNQVDSKY 921

Human  1794 ------MLASFCGGALEPMPTEEDEADDTSASIISDLIC--QGAQLGARTDRTGETALHLAARYA 1850
                  .||:...|..|.:.|.|            .:.|  .||.:.|| |....|||.||.|..
 Worm   922 RRRVLHWLAANVRGKPEDVITTE------------AIRCLKAGADVNAR-DCDENTALMLAVRAH 973

Human  1851 RADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRS--TDLDARMADGSTALILA 1913
            |...:..||..||:....::|.|:.||.||......:.:.|:.::.  .::|....:|.|||:|.
 Worm   974 RVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLTDKRLLKEIDELDRNGMTALMLV 1038

Human  1914 ARLAVEGMVE--ELI-----------ASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANK 1965
            ||...:..||  ||:           |:..|.|...  |::|||:||..:|.|..:.|::..:||
 Worm  1039 ARELGKHQVEMAELLLSKGAKLDYDGAARKDSNKYK--GRTALHYAAMHDNEEMVIMLVRRSSNK 1101

Human  1966 DMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGP 2030
            |.||....||:.|||:||..:..:.|..:.|:..|.|.:|.....||:...|.::...|.|.:..
 Worm  1102 DKQDEDGRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEASYHHELAAFLRQVANE 1166

Human  2031 RSPPGPHGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADS 2095
            |                          ..:...|:...|:|.|.:..|...|.:..|.......|
 Worm  1167 R--------------------------HRNDIMRQQIVKSGHGAKSGRQTVKNIKRAGSRKTPTS 1205

Human  2096 SVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQ--------P 2152
            :.:....:.|.       ||.|.|.|....|:...|.|:.       |.|.....:        |
 Worm  1206 AASSRETNHLT-------PPPSDGSFSSPSPHYYPTTTST-------PNRMETSPEYMFNHEMAP 1256

Human  2153 PGGCVLSLGLLNPVAVPLDWARLPPP--------APPGPSF 2185
            |              |...|...|||        .||..:|
 Worm  1257 P--------------VNAMWYTTPPPYQDPNYRHVPPNTAF 1283

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH3NP_000426.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
EGF_CA 158..195 CDD:238011
EGF_CA 236..272 CDD:238011
EGF_CA 274..311 CDD:238011
EGF_CA 314..349 CDD:238011
EGF_CA 391..429 CDD:238011
EGF_CA 431..467 CDD:238011
EGF_CA 469..505 CDD:238011
EGF_CA 507..542 CDD:238011
EGF_CA 545..580 CDD:238011
EGF_CA 583..618 CDD:238011 14/35 (40%)
EGF_CA 620..654 CDD:238011 8/35 (23%)
EGF_CA 657..>686 CDD:214542 7/28 (25%)
EGF_CA 810..846 CDD:238011 15/35 (43%)
EGF_CA 849..884 CDD:238011 12/35 (34%)
EGF_CA 887..922 CDD:238011 6/34 (18%)
EGF_CA 929..960 CDD:238011 12/32 (38%)
EGF_CA 1085..1120 CDD:238011 13/34 (38%)
EGF_CA 1122..1158 CDD:238011 7/35 (20%)
EGF_CA 1171..1203 CDD:238011 2/31 (6%)
Notch 1384..1418 CDD:459658 8/33 (24%)
LNR 1 1387..1427 12/41 (29%)
Notch 1425..1458 CDD:459658 10/33 (30%)
LNR 2 1428..1458 10/30 (33%)
LNR 3 1467..1505 13/37 (35%)
Notch 1474..1500 CDD:459658 9/25 (36%)
NOD 1505..1560 CDD:462014 14/60 (23%)
NODP 1577..1637 CDD:462229 20/68 (29%)
JMTM_Notch3 1618..1709 CDD:411987 23/108 (21%)
ANK repeat 1788..1836 CDD:293786 14/68 (21%)
ANKYR 1818..2043 CDD:440430 71/241 (29%)
ANK repeat 1838..1869 CDD:293786 11/30 (37%)
ANK 1 1838..1867 11/28 (39%)
ANK repeat 1871..1903 CDD:293786 8/33 (24%)
ANK 2 1871..1901 7/31 (23%)
ANK repeat 1905..1936 CDD:293786 14/43 (33%)
ANK 3 1905..1934 13/41 (32%)
ANK repeat 1938..1969 CDD:293786 12/30 (40%)
ANK 4 1938..1967 11/28 (39%)
ANK repeat 1971..2002 CDD:293786 10/30 (33%)
ANK 5 1971..2000 9/28 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2024..2120 15/95 (16%)
PHA03247 <2045..2318 CDD:223021 29/157 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2190..2321
glp-1NP_499014.1 EGF_CA 118..152 CDD:238011 14/33 (42%)
EGF_CA 155..190 CDD:238011 12/36 (33%)
EGF_CA 232..269 CDD:238011 15/36 (42%)
EGF_CA 369..406 CDD:238011 13/85 (15%)
EGF_CA 451..479 CDD:238011 12/116 (10%)
NL 489..526 CDD:197463 18/137 (13%)
Notch 533..568 CDD:459658 11/34 (32%)
Notch 573..608 CDD:459658 12/34 (35%)
NOD 611..665 CDD:462014 14/55 (25%)
ANK repeat 921..959 CDD:293786 11/50 (22%)
ANKYR <945..1172 CDD:440430 71/255 (28%)
ANK repeat 961..992 CDD:293786 11/30 (37%)
ANK repeat 994..1028 CDD:293786 8/33 (24%)
ANK repeat 1030..1061 CDD:293786 11/30 (37%)
ANK repeat 1071..1105 CDD:293786 13/35 (37%)
ANK repeat 1107..1138 CDD:293786 10/30 (33%)
ANK repeat 1140..1170 CDD:293786 7/55 (13%)
Blue background indicates that the domain is not in the aligned region.

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