DRSC/TRiP Functional Genomics Resources

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Protein Alignment NOTCH3 and lin-12

DIOPT Version :10

Sequence 1:NP_000426.2 Gene:NOTCH3 / 4854 HGNCID:7883 Length:2321 Species:Homo sapiens
Sequence 2:NP_499007.1 Gene:lin-12 / 176282 WormBaseID:WBGene00003001 Length:1429 Species:Caenorhabditis elegans


Alignment Length:1826 Identity:435/1826 - (23%)
Similarity:642/1826 - (35%) Gaps:614/1826 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   404 HLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCE- 467
            |:|.|:.      ..|||.          ..|.:||.....|      .:.|.|..||.|.||| 
 Worm    20 HIGSCLG------LICGRN----------GHCHAGPVNGTQT------SYWCRCDEGFGGEYCEQ 62

Human   468 -VDIDEC-QSSPCV-------NGGVCKD-RVNGFSC---TCPSGFSGSTCQLDVDECASTPCRNG 519
             .|:.:| ....||       ...|||| .:||.|.   :||||:.|..|:.. ..|..:.|.||
 Worm    63 QCDVSKCGADEKCVFDKDYRMETCVCKDCDINGNSLLKPSCPSGYGGDDCKTQ-GWCYPSVCMNG 126

Human   520 AKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVD 584
            .:|:...:..:|.|.:||:|..|:.:|::|                                   
 Worm   127 GQCIGAGNRAKCACPDGFKGERCELDVNEC----------------------------------- 156

Human   585 ECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPG- 648
            |.....|.:...|::.:..|:|.||.|....:|                           .:|| 
 Worm   157 EENKNACGNRSTCMNTLGTYICVCPQGFLPPDC---------------------------LKPGN 194

Human   649 -----FTGPLCNVEINECASSPCGEGGSCVDGENGF------RCLCPPGSLPPLC--LPPSHPCA 700
                 |..|:|.:||:  |..|.|....|.:|  ||      :|.||||.....|  |.....||
 Worm   195 TSTVEFKQPVCFLEIS--ADHPDGRSMYCQNG--GFCDKASSKCQCPPGYHGSTCELLEKEDSCA 255

Human   701 HEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQ 765
            ..|||||:|....|||:|:|:.|:||..|.:  .:|.|.:..|.||..|.:....:.|.|||...
 Worm   256 SNPCSHGVCISFSGGFQCICDDGYSGSYCQE--GKDNCVNNKCEAGSKCINGVNSYFCDCPPERT 318

Human   766 GRQCELLSPCT--PNPCEHGGRCESAP--GQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGIC 826
            |..||.:. |:  |:.|.| |.|..:|  .:...|.|..|::|..|:||.:||.....|..:|.|
 Worm   319 GPYCEKMD-CSAIPDICNH-GTCIDSPLSEKAFECQCEPGYEGILCEQDKNECLSENMCLNNGTC 381

Human   827 TNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSC-QDGVGSFSCSCLPGFAGPRCARDVDE 890
            .||.|||.|.|..|:.|..||:.:|.|....|.|.|:| .....|..|.|..||.|.||.::   
 Worm   382 VNLPGSFRCDCARGFGGKWCDEPLNMCQDFHCENDGTCMHTSDHSPVCQCKNGFIGKRCEKE--- 443

Human   891 CLSNPCGPGTCTDHVASFTCTCPPGYGGFHCE--QDLPDCS--PSSCFNGGTCVDGVNSFSCLCR 951
                                 ||.|:||..|:  .::..||  ...|||||.|:.|.    |:|.
 Worm   444 ---------------------CPIGFGGVRCDLRLEIGICSRQGGKCFNGGKCLSGF----CVCP 483

Human   952 PGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCV 1016
            |.:||..|:      ::|   ..|..|.:.                    :.|...||.|...|:
 Worm   484 PDFTGNQCE------VNR---KNGKSSLSE--------------------NLCLSDPCMNNATCI 519

Human  1017 QTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHC 1081
            .                                            ||....:.|:|.:|..|..|
 Worm   520 D--------------------------------------------VDAHIGYACICKQGFEGDIC 540

Human  1082 EQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDD-VDECASQPCQHGGSCIDLVARYL 1145
            |:..|.||..||.:||.|..:...:.|:|.||:.|:.||.: :..|....||:||.|        
 Worm   541 ERHKDLCLENPCSNGGVCHQHRESFSCDCPPGFYGNGCEQEKMFRCLKSTCQNGGVC-------- 597

Human  1146 CSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECR 1210
                         |||::                       .|.:|.|..|::|.|||..||   
 Worm   598 -------------INEEE-----------------------KGRKCECSYGFSGARCEEKIN--- 623

Human  1211 SGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTC 1275
                                    ..||:                                    
 Worm   624 ------------------------LTGFT------------------------------------ 628

Human  1276 HCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCA 1340
                     ..:.:.||.                                               
 Worm   629 ---------EKDSLLRSV----------------------------------------------- 637

Human  1341 AAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDREC 1405
                                                          |.:..|..:..|..||.:|
 Worm   638 ----------------------------------------------CEKRKCSERANDGNCDADC 656

Human  1406 NSPGCGWDGGDCSLSVGDPWRQCE-ALQCWRLFNNSRCDPACSSPACLYDNFDC-HAGGRERTCN 1468
            |...|.:|||||| ...:|:.:|. ...|...|.|..|:.||::..||||..|| .|..|   |.
 Worm   657 NYAACKFDGGDCS-GKREPFSKCRYGNMCADFFANGVCNQACNNEECLYDGMDCLPAVVR---CP 717

Human  1469 PVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQ 1533
            ....::||..||:|.||..|||..||:||.||.:|..|.:...:.: ||.:.|:|...:....|.
 Worm   718 VKIREHCASRFANGICDPECNTNGCGFDGGDCDNETNATIITNIRI-TVQMDPKEFQVTGGQSLM 781

Human  1534 RLSAILRTSLRFRLDAHGQAMVFPYHRPSPGSEPRA-RRELAPE----------------VIGSV 1581
            .:|:.||.::|.:.|..| .:||.::..|.....:. .|:|..:                .||.|
 Worm   782 EISSALRVTVRIQRDEEG-PLVFQWNGESEMDRVKMNERQLTEQHVLSTSISRKIKRSATNIGVV 845

Human  1582 VMLEI----DNRLCLQSPENDHCFPDAQSAADYLGALSAVERLD-FPYPLRD-VRGEPLEPPEP- 1639
            |.||:    |...||        :.||||..|.:.|..|.:.:| |..|:.: :..||.:.... 
 Worm   846 VYLEVQENCDTGKCL--------YKDAQSVVDSISARLAKKGIDSFGIPISEALVAEPRKSGNNT 902

Human  1640 ---SVPLLPLLVAGAVLLLVILVLGVMVARRKRE----HSTLWFPEGFSLHKDVASGHKGRREPV 1697
               |...|.|:.||.::::|:|:||.:...|.|:    ::::|.|                  |:
 Worm   903 GFLSWNALLLIGAGCLIVMVVLMLGALPGNRTRKRRMINASVWMP------------------PM 949

Human  1698 GQDALGMKN---MAKGESLMGEVATDWMDTECPEAKRLKVEEPGMGAEEAVDCRQWTQHHLVAAD 1759
            ..:....||   :...:..:.|.:.|..      .||.:.|               .||:     
 Worm   950 ENEEKNRKNHQSITSSQHSLLEASYDGY------IKRQRNE---------------LQHY----- 988

Human  1760 IRVAPAMALTP-PQG-----DADADGMDVNVR---GPDGFTPLMLASFCGGA---LEPMPTEEDE 1812
                   :|.| |||     |...|....|::   .|:..:|:.|.:...|:   .||:..|...
 Worm   989 -------SLYPNPQGYGNGNDFLGDFNHTNLQIPTEPEPESPIKLHTEAAGSYAITEPITRESVN 1046

Human  1813 --------------ADDTSASIISDL--------ICQGAQLGARTDRTGETALHLAARYARADAA 1855
                          |.::||....||        |..||.:.| .|....|.|.||....|....
 Worm  1047 IIDPRHNRTVLHWIASNSSAEKSEDLIVHEAKECIAAGADVNA-MDCDENTPLMLAVLARRRRLV 1110

Human  1856 KRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRST--DLDARMADGSTALIL------ 1912
            ..|:.||||....:.|.|:.||.|......|:...::.:...  |::....:|.|||::      
 Worm  1111 AYLMKAGADPTIYNKSERSALHQAAANRDFGMMVYMLNSTKLKGDIEELDRNGMTALMIVAHNEG 1175

Human  1913 -----AARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALL-KNGANKDMQDSK 1971
                 :|:|.||...:......|..::....|::|||:||.|:|:.....|: :.|:|||.||..
 Worm  1176 RDQVASAKLLVEKGAKVDYDGAARKDSEKYKGRTALHYAAQVSNMPIVKYLVGEKGSNKDKQDED 1240

Human  1972 EETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGP 2036
            .:||:.|||:||..|....|:...|:.|..|..|...|.:||...|.:||.:.|:          
 Worm  1241 GKTPIMLAAQEGRIEVVMYLIQQGASVEAVDATDHTARQLAQANNHHNIVDIFDR---------- 1295

Human  2037 HGLGPLLCPP------GAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADS 2095
                   |.|      ...:......|...|.:|.|..:.....:......:..|...|.|...|
 Worm  1296 -------CRPEREYSMDLHIQHTHQPQPSRKVTRAPKKQTSRSKKESASNSRDSTHLTPPPSDGS 1353

Human  2096 SVTLSP 2101
            :.|.||
 Worm  1354 TSTPSP 1359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH3NP_000426.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
EGF_CA 158..195 CDD:238011
EGF_CA 236..272 CDD:238011
EGF_CA 274..311 CDD:238011
EGF_CA 314..349 CDD:238011
EGF_CA 391..429 CDD:238011 6/24 (25%)
EGF_CA 431..467 CDD:238011 10/35 (29%)
EGF_CA 469..505 CDD:238011 16/47 (34%)
EGF_CA 507..542 CDD:238011 10/34 (29%)
EGF_CA 545..580 CDD:238011 2/34 (6%)
EGF_CA 583..618 CDD:238011 8/34 (24%)
EGF_CA 620..654 CDD:238011 4/39 (10%)
EGF_CA 657..>686 CDD:214542 12/34 (35%)
EGF_CA 810..846 CDD:238011 15/35 (43%)
EGF_CA 849..884 CDD:238011 12/35 (34%)
EGF_CA 887..922 CDD:238011 5/34 (15%)
EGF_CA 929..960 CDD:238011 13/32 (41%)
EGF_CA 1085..1120 CDD:238011 13/34 (38%)
EGF_CA 1122..1158 CDD:238011 6/36 (17%)
EGF_CA 1171..1203 CDD:238011 6/31 (19%)
Notch 1384..1418 CDD:459658 12/33 (36%)
LNR 1 1387..1427 15/39 (38%)
Notch 1425..1458 CDD:459658 11/33 (33%)
LNR 2 1428..1458 11/30 (37%)
LNR 3 1467..1505 18/37 (49%)
Notch 1474..1500 CDD:459658 14/25 (56%)
NOD 1505..1560 CDD:462014 14/54 (26%)
NODP 1577..1637 CDD:462229 21/65 (32%)
JMTM_Notch3 1618..1709 CDD:411987 21/103 (20%)
ANK repeat 1788..1836 CDD:293786 15/72 (21%)
ANKYR 1818..2043 CDD:440430 69/246 (28%)
ANK repeat 1838..1869 CDD:293786 10/30 (33%)
ANK 1 1838..1867 10/28 (36%)
ANK repeat 1871..1903 CDD:293786 7/33 (21%)
ANK 2 1871..1901 7/31 (23%)
ANK repeat 1905..1936 CDD:293786 9/41 (22%)
ANK 3 1905..1934 9/39 (23%)
ANK repeat 1938..1969 CDD:293786 13/31 (42%)
ANK 4 1938..1967 12/29 (41%)
ANK repeat 1971..2002 CDD:293786 11/30 (37%)
ANK 5 1971..2000 10/28 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2024..2120 14/84 (17%)
PHA03247 <2045..2318 CDD:223021 12/63 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2190..2321
lin-12NP_499007.1 EGF_CA 152..189 CDD:238011 10/71 (14%)
EGF_2 220..245 CDD:400365 9/26 (35%)
EGF_CA 252..285 CDD:238011 16/32 (50%)
EGF_CA 293..323 CDD:238011 9/29 (31%)
EGF_CA 365..401 CDD:238011 15/35 (43%)
EGF_CA 505..541 CDD:238011 11/79 (14%)
EGF_CA 545..579 CDD:238011 13/33 (39%)
NL 635..668 CDD:197463 13/125 (10%)
Notch 675..709 CDD:459658 11/33 (33%)
Notch 715..750 CDD:459658 17/37 (46%)
NOD 753..807 CDD:462014 14/55 (25%)
NODP 842..898 CDD:462229 21/63 (33%)
ANK repeat 1052..1091 CDD:293786 9/39 (23%)
ANKYR 1070..1295 CDD:440430 67/225 (30%)
ANK repeat 1093..1124 CDD:293786 10/30 (33%)
ANK repeat 1126..1160 CDD:293786 7/33 (21%)
ANK repeat 1162..1201 CDD:293786 9/38 (24%)
ANK repeat 1203..1238 CDD:293786 13/34 (38%)
ANK repeat 1240..1271 CDD:293786 11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

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