DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb87F and RBM19

DIOPT Version :9

Sequence 1:	NP_001163602.1	Gene:	Hrb87F / 48535	FlyBaseID:	FBgn0004237	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001140170.1	Gene:	RBM19 / 9904	HGNCID:	29098	Length:	960	Species:	Homo sapiens

Alignment Length:	189	Identity:	56/189 - (29%)
Similarity:	85/189 - (44%)	Gaps:	40/189 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AEQNDSNGNYDDGEEITEPEQLR--KLFIGGLDYRTTDDGLKAHFEKWGNIVDVVVMKDPKTKR- 63
            |:.:.:....::.||..|.|.|.  .|||..|::.||::.||..|.|.|.:....:.| .|.|.
Human   706 ADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSISK-KKNKAG 769

  Fly    64 ---SRGFGFITYSQSYMIDNAQNA----RPHKIDG---------RTVEP------KRAVPRQEID 106
               |.||||:.|.:.   :.||.|    :.|.:||         |..:|      |:.|||::
Human   770 VLLSMGFGFVEYRKP---EQAQKALKQLQGHVVDGHKLEVRISERATKPAVTLARKKQVPRKQ-- 829

  Fly   107 SPNAGATVKKLFVGGLR-DDHDEECLREYFKDFGQIVSVNIVSD-KDTGKKRGFAFIEF 163
                  |..|:.|..:. ..|..| :||.|..||::.:|.:... ..||..|||.|::|
Human   830 ------TTSKILVRNIPFQAHSRE-IRELFSTFGELKTVRLPKKMTGTGTHRGFGFVDF 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb87F	NP_001163602.1	RRM1_hnRNPA_like	25..102	CDD:241022	30/99 (30%)
Hrb87F	NP_001163602.1	RRM_SF	116..188	CDD:302621	17/50 (34%)
RBM19	NP_001140170.1	RRM	<2..>104	CDD:223796
		RRM1_RBM19	2..77	CDD:241008
		RRM_u2	82..286	CDD:293257
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..119
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..294
		RRM	<270..450	CDD:223796
		RRM2_RMB19	294..365	CDD:240946
		RRM	<400..>500	CDD:223796
		RRM3_RBM19	400..478	CDD:241011
		RRM	477..801	CDD:223796	30/98 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..513
		RRM4_RBM19	587..658	CDD:241013
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..729		6/22 (27%)
		RRM5_RBM19_like	730..809	CDD:240764	26/82 (32%)
		RRM6_RBM19	832..910	CDD:241015	17/51 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910