DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb87F and DAZ4

DIOPT Version :9

Sequence 1:	NP_001163602.1	Gene:	Hrb87F / 48535	FlyBaseID:	FBgn0004237	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001375413.1	Gene:	DAZ4 / 57135	HGNCID:	15966	Length:	723	Species:	Homo sapiens

Alignment Length:	249	Identity:	51/249 - (20%)
Similarity:	99/249 - (39%)	Gaps:	84/249 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LFIGGLDYRTTDDGLKAHFEKWGNIVDVVVMKDPKTKRSRGFGFITYSQSYMIDNAQNARPH--- 87
            :|:||:|.|..:..:.:.|.::|::.:|.::.: :|..|:|:||:::.....:.....::.|
Human    42 VFVGGIDARMDETEIGSCFGRYGSVKEVKIITN-RTGVSKGYGFVSFVNDVDVQKIVGSQIHFHG 105

  Fly    88 ------------KIDGRTVEPKRAV---------------PRQEI-------------------- 105
                        |:..|.|:|:..|               |..|.
Human   106 KKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAAN 170

  Fly   106 -DSPNAGATVKK--------------------------LFVGGLRDDHDEECLREYFKDFGQIVS 143
             ::||  :|:.:                          :||||:....||..:...|..:|.:..
Human   171 PETPN--STISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKE 233

  Fly   144 VNIVSDKDTGKKRGFAFIEF-DDYDPVDKIILQKTHSIKNKTLDVKKAIAKQDM 196
            |.|:::: ||..:|:.|:.| :|.| |.||:..:.| ...|.|.:..||.||.:
Human   234 VKIITNR-TGVSKGYGFVSFVNDVD-VQKIVGSQIH-FHGKKLKLGPAIRKQKL 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb87F	NP_001163602.1	RRM1_hnRNPA_like	25..102	CDD:241022	19/105 (18%)
Hrb87F	NP_001163602.1	RRM_SF	116..188	CDD:302621	23/98 (23%)
DAZ4	NP_001375413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		RRM_DAZL	35..116	CDD:410073	14/74 (19%)
		PABP-1234	42..412	CDD:130689	51/249 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..192		3/30 (10%)
		RRM_DAZL	200..281	CDD:410073	25/83 (30%)
		Daz	407..427	CDD:408642
		Daz	431..451	CDD:408642
		Daz	455..475	CDD:408642
		Daz	479..499	CDD:408642
		Daz	503..523	CDD:408642
		Daz	527..547	CDD:408642
		Daz	551..571	CDD:408642
		Daz	575..595	CDD:408642
		Daz	599..619	CDD:408642
		Daz	623..643	CDD:408642
		Daz	647..667	CDD:408642
		Daz	671..691	CDD:408642
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910