DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb87F and hnrnpa1

DIOPT Version :9

Sequence 1:	NP_001163602.1	Gene:	Hrb87F / 48535	FlyBaseID:	FBgn0004237	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	XP_012812298.1	Gene:	hnrnpa1 / 496507	XenbaseID:	XB-GENE-493963	Length:	362	Species:	Xenopus tropicalis

Alignment Length:	384	Identity:	191/384 - (49%)
Similarity:	245/384 - (63%)	Gaps:	47/384 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EPEQLRKLFIGGLDYRTTDDGLKAHFEKWGNIVDVVVMKDPKTKRSRGFGFITYSQSYMIDNAQN 83
            |||||||||||||.:.|||:.|:.|||:||.:.|.|||:||.:||||||||:|||.:..:|.|.:
Frog     9 EPEQLRKLFIGGLSFETTDESLREHFEQWGTLTDCVVMRDPNSKRSRGFGFVTYSSTDEVDAAMS 73

  Fly    84 ARPHKIDGRTVEPKRAVPRQEIDSPNAGATVKKLFVGGLRDDHDEECLREYFKDFGQIVSVNIVS 148
            |||||:|||.|||||||.|::...|.|..||||:||||:::|.:|..|||||:.:|:|..:.|::
Frog    74 ARPHKVDGRVVEPKRAVSREDSSRPGAHLTVKKIFVGGIKEDTEEHHLREYFEQYGKIEVIEIMT 138

  Fly   149 DKDTGKKRGFAFIEFDDYDPVDKIILQKTHSIKNKTLDVKKAIAKQDM-----DRQGGGG----- 203
            |:.:||||||||:.|:|:|.||||::||.|::.|...:|:||::||:|     .::|.||
Frog   139 DRGSGKKRGFAFVTFEDHDSVDKIVIQKYHTVNNHNCEVRKALSKQEMASVSGSQRGRGGSGNFS 203

  Fly   204 GRGG---PRAGGRGGQGDRGQGGGGWGGQNRQNGGGNWGGAGGGGGFGN----SGGNFGGGQGGG 261
            ||||   ...|||||.....: |||:|  ||..||..:.|.|..||:|.    ||||.|.|.|||
Frog   204 GRGGFGNDNFGGRGGNFSSNR-GGGFG--NRGYGGDGYNGFGNDGGYGGSPPYSGGNRGYGGGGG 265

  Fly   262 SGGWNQQGGSGGGPWNNQGGGNGGWNGGGGGGYGGGNSNGSWGGNGGGGGGGGGFGNEYQQSYGG 326
            .|   ..||.|||    .||||||::|..|||.|.|.|.|::||:||||||...|||...||
Frog   266 QG---YGGGQGGG----YGGGNGGYDGYNGGGSGFGGSGGNFGGSGGGGGGYNDFGNYNNQS--- 320

  Fly   327 GPQRNSNFGNNRPAPYSQGGGGGGFNKGNQGGGQGFAGNNYNTGGGGQGGNMGGGNRRY 385
                :|:||     |...|..|||.|.|..|||.|        ||.|...:..||.||:
Frog   321 ----SSSFG-----PMKGGNYGGGRNSGPYGGGYG--------GGSGSSSSGYGGGRRF 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb87F	NP_001163602.1	RRM1_hnRNPA_like	25..102	CDD:241022	50/76 (66%)
Hrb87F	NP_001163602.1	RRM_SF	116..188	CDD:302621	35/71 (49%)
hnrnpa1	XP_012812298.1	RRM1_hnRNPA1	12..92	CDD:241205	53/79 (67%)
		RRM2_hnRNPA1	105..181	CDD:241024	38/75 (51%)
		HnRNPA1	<315..>334	CDD:371635	8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6748
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2204
OMA	1	1.010	-	-		QHG46466
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2767
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.010