DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb87F and CCDC88C

DIOPT Version :9

Sequence 1:	NP_001163602.1	Gene:	Hrb87F / 48535	FlyBaseID:	FBgn0004237	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001073883.2	Gene:	CCDC88C / 440193	HGNCID:	19967	Length:	2028	Species:	Homo sapiens

Alignment Length:	171	Identity:	30/171 - (17%)
Similarity:	61/171 - (35%)	Gaps:	31/171 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EKWGNIVDVVVMKDPKTKR-------SRGFGFITYSQSYMIDNAQNA--------RPHK-IDGRT 93
            |:.|.:...|...:..|::       |:|......:....:|..||.        |.:| :|...
Human   642 EENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAEN 706

  Fly    94 VEPKRAVPRQEIDSPNAGATVKKLFVGGLRDDHDEECLREYFKDFGQIVSVNIVSDKDTGKKRGF 158
            :|.:|.|......|.......::    ..:.:.::|.||:           |:...|..|||...
Human   707 LELRRLVETMRFTSTKLAQMERE----NQQLEREKEELRK-----------NVDLLKALGKKSER 756

  Fly   159 AFIEFDDYDPVDKIILQKTHSIKNKTLDVKKAIAKQDMDRQ 199
            ..:.:......:..:.|...|..:||..::..:.:.:.:||
Human   757 LELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQ 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb87F	NP_001163602.1	RRM1_hnRNPA_like	25..102	CDD:241022	15/72 (21%)
Hrb87F	NP_001163602.1	RRM_SF	116..188	CDD:302621	12/71 (17%)
CCDC88C	NP_001073883.2	HOOK	17..633	CDD:283312
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..250
		Myosin_tail_1	329..1319	CDD:279860	30/171 (18%)
		RILP-like	<489..601	CDD:304877
		DUF2570	664..>741	CDD:305162	13/80 (16%)
		RILP-like	<755..868	CDD:304877	6/43 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1043
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1419..1724
		GBA. /evidence=ECO:0000269\|PubMed:30194280	1661..1691
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1736..1803
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1816..2021
		PDZ-binding. /evidence=ECO:0000255	2025..2028
		DVL1-binding. /evidence=ECO:0000250\|UniProtKB:Q6VGS5	2026..2028
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910