DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb87F and hnrnpa1a

DIOPT Version :9

Sequence 1:	NP_001163602.1	Gene:	Hrb87F / 48535	FlyBaseID:	FBgn0004237	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	XP_021335234.1	Gene:	hnrnpa1a / 393467	ZFINID:	ZDB-GENE-040426-1546	Length:	445	Species:	Danio rerio

Alignment Length:	428	Identity:	203/428 - (47%)
Similarity:	256/428 - (59%)	Gaps:	76/428 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EPEQLRKLFIGGLDYRTTDDGLKAHFEKWGNIVDVV----------------------------V 55
            |||||||||||||.:.|||:.|:||||:||.:.|.|                            |
Zfish    33 EPEQLRKLFIGGLSFETTDESLRAHFEQWGTLTDCVVSPSAAIHMLMYEREEHLKVAGFLYCSQV 97

  Fly    56 MKDPKTKRSRGFGFITYSQSYMIDNAQNARPHKIDGRTVEPKRAVPRQEIDSPNAGATVKKLFVG 120
            |:||.|||||||||:|||....:|.|.:|||||:|||.|||||||.|::...|.|.:||||:|||
Zfish    98 MRDPNTKRSRGFGFVTYSSVGEVDAAMDARPHKVDGRAVEPKRAVSREDSSKPGAHSTVKKMFVG 162

  Fly   121 GLRDDHDEECLREYFKDFGQIVSVNIVSDKDTGKKRGFAFIEFDDYDPVDKIILQKTHSIKNKTL 185
            |:::|.|||.|||||..||:|..|||:::|::.|:||||||.|||:|.||:|::||.|::.....
Zfish   163 GIKEDTDEEHLREYFGQFGKIDEVNIMTEKNSDKRRGFAFITFDDHDAVDRIVIQKYHTVNGHNC 227

  Fly   186 DVKKAIAKQDMDR--------QGGGGGRGGPRAGGRGGQGDRGQGGGGWGGQNRQNGGGNWGGA- 241
            :|:||:::::|:|        :|||||.||...|..||.|..|..|||:||...:.|||.:||.
Zfish   228 EVRKALSREEMNRVSMNSRGGRGGGGGSGGGNFGRGGGGGGGGGYGGGYGGGGGRGGGGGYGGGD 292

  Fly   242 -----GGG-------GGFGNSGGNFGGGQGGGSGGWNQQGGSGGGPWNNQGGGNGG-----WNGG 289
                 |||       .|:|..|.|:||.:|.||||    ||.|||.:.|||||.||     :|..
Zfish   293 GYNGYGGGNGISTDKSGYGGGGPNYGGNRGYGSGG----GGGGGGGYGNQGGGYGGGGYDNYNNN 353

  Fly   290 GGGGYGGGNSNGSWGGNGGGGGGGGGFGNEYQQSYGGGPQRNSNFGNNRPAPYSQGGGGGGFN-- 352
            ||||.||||..   |||.||||....|||...||       :||:|..:...|..||||||.:
Zfish   354 GGGGGGGGNFG---GGNFGGGGDYNDFGNYNNQS-------SSNYGPMKGGNYGGGGGGGGRSGG 408

  Fly   353 ---KGNQGGGQGFAGNNYNTGGGGQGGNMGGGN--RRY 385
               .|..|||.| .|..|..|.||.||..|||:  ||:
Zfish   409 GPYGGGYGGGSG-GGGGYGGGSGGGGGGYGGGSGGRRF 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb87F	NP_001163602.1	RRM1_hnRNPA_like	25..102	CDD:241022	52/104 (50%)
Hrb87F	NP_001163602.1	RRM_SF	116..188	CDD:302621	38/71 (54%)
hnrnpa1a	XP_021335234.1	RRM_SF	36..144	CDD:327398	55/107 (51%)
		RRM_SF	157..233	CDD:327398	41/75 (55%)
		HnRNPA1	376..>392	CDD:314495	8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6875
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1965
OMA	1	1.010	-	-		QHG46466
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	1	1.000	-	-		mtm6517
orthoMCL	1	0.900	-	-		OOG6_103644
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2767
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910