DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb87F and Hnrnpa3

DIOPT Version :9

Sequence 1:	NP_001163602.1	Gene:	Hrb87F / 48535	FlyBaseID:	FBgn0004237	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001104764.1	Gene:	Hnrnpa3 / 362152	RGDID:	727807	Length:	379	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	198/393 - (50%)
Similarity:	247/393 - (62%)	Gaps:	55/393 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DDGEEITEPEQLRKLFIGGLDYRTTDDGLKAHFEKWGNIVDVVVMKDPKTKRSRGFGFITYSQSY 76
            ::|.:..|||||||||||||.:.||||.|:.||||||.:.|.|||:||:|||||||||:|||...
  Rat    23 EEGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVE 87

  Fly    77 MIDNAQNARPHKIDGRTVEPKRAVPRQEIDSPNAGATVKKLFVGGLRDDHDEECLREYFKDFGQI 141
            .:|.|..|||||:|||.|||||||.|::...|.|..||||:||||:::|.:|..||:||:.:|:|
  Rat    88 EVDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKI 152

  Fly   142 VSVNIVSDKDTGKKRGFAFIEFDDYDPVDKIILQKTHSIKNKTLDVKKAIAKQDMDRQG-----G 201
            .::.::.|:.:||||||||:.|||:|.||||::||.|:|.....:||||::||:|...|     |
  Rat   153 ETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRG 217

  Fly   202 GG-----GRGGPRAG-----GRGGQ-GDRGQGGGGWGGQNRQNGGGNWGGAGGGGGFGNSGGNFG 255
            ||     ||||...|     ||||. |.||..|||.||.....|||:    ||..|||..|||:|
  Rat   218 GGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGD----GGYNGFGGDGGNYG 278

  Fly   256 GGQGGGSGGWNQQGGSGGGP-WNNQGGGNGGWNGGGGGGYGGGNSNGSW-GGNGGGGGGGGGFGN 318
            ||.|..|.|    |..|||| :.|||||    .|||||||.|.|..|:: |||.||||....|||
  Rat   279 GGPGYSSRG----GYGGGGPGYGNQGGG----YGGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGN 335

  Fly   319 EYQQSYGGGPQRNSNFGNNRPAPYSQGGGGGGFNKGN-QGGGQGFAGNNYNTGGGGQGGNMGGGN 382
                 |.|  |:.||:|.      .:||..||.:.|: .|||.|        .|||.||.   |:
  Rat   336 -----YSG--QQQSNYGP------MKGGSFGGRSSGSPYGGGYG--------SGGGSGGY---GS 376

  Fly   383 RRY 385
            ||:
  Rat   377 RRF 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb87F	NP_001163602.1	RRM1_hnRNPA_like	25..102	CDD:241022	53/76 (70%)
Hrb87F	NP_001163602.1	RRM_SF	116..188	CDD:302621	34/71 (48%)
Hnrnpa3	NP_001104764.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		5/11 (45%)
		RRM1_hnRNPA_like	36..113	CDD:409992	53/76 (70%)
		RRM2_hnRNPA3	126..205	CDD:409996	39/78 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..225		7/20 (35%)
		HnRNPA1	332..>348	CDD:402981	9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..379		23/67 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6662
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	348	1.000	Inparanoid score	I2227
OMA	1	1.010	-	-		QHG46466
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	1	1.000	-	-		mtm8985
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.980