DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb87F and HNRNPAB

DIOPT Version :9

Sequence 1:	NP_001163602.1	Gene:	Hrb87F / 48535	FlyBaseID:	FBgn0004237	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_112556.2	Gene:	HNRNPAB / 3182	HGNCID:	5034	Length:	332	Species:	Homo sapiens

Alignment Length:	338	Identity:	114/338 - (33%)
Similarity:	169/338 - (50%)	Gaps:	63/338 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NGNYDDGEEIT---EPEQLRKLFIGGLDYRTTDDGLKAHFEKWGNIVDVVVMKDPKTKRSRGFGF 69
            |.|..:|::|.   ..|...|:|:|||.:.|:...||.:|.|:|.:||..:..||.|.|||||||
Human    51 NQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGF 115

  Fly    70 ITYSQSYMIDNAQNARPHKIDGRTVEPKRAVPRQEIDSPNAGATVKKLFVGGLRDDHDEECLREY 134
            |.:..:..::...:.:.|::|||.::||:|:..::  .|     |||:|||||..:..||.:|||
Human   116 ILFKDAASVEKVLDQKEHRLDGRVIDPKKAMAMKK--DP-----VKKIFVGGLNPEATEEKIREY 173

  Fly   135 FKDFGQIVSVNIVSDKDTGKKRGFAFIEFDDYDPVDKIILQKTHSIKNKTLDVKKAIAKQDMDRQ 199
            |.:||:|.::.:..|....|:|||.||.|.:.:||.|::.:|.|::.....::|.|..|:...:|
Human   174 FGEFGEIEAIELPMDPKLNKRRGFVFITFKEEEPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQ 238

  Fly   200 GGGGGRGGPRAGGRGGQGDRGQGGGGWGGQNRQNGGGNWGGAGGGGGFGNSGGNFGGGQGGGSGG 264
                                ..|.||.|.:||    ||.|..|||||            ||.|..
Human   239 --------------------QYGSGGRGNRNR----GNRGSGGGGGG------------GGQSQS 267

  Fly   265 WNQQGGSGGGPWNNQGGGNGGWNGGGGGGYGGGNSNGSWGGNGGGGGGGGGFGNEYQQ---SYGG 326
            |||    |.|.:.|||   .|:..|.|.||||.:.:..       |..|.|.|.:|.|   :||.
Human   268 WNQ----GYGNYWNQG---YGYQQGYGPGYGGYDYSPY-------GYYGYGPGYDYSQGSTNYGK 318

  Fly   327 GPQRNSNFGNNRP 339
            ..:|..:..|.:|
Human   319 SQRRGGHQNNYKP 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb87F	NP_001163602.1	RRM1_hnRNPA_like	25..102	CDD:241022	31/76 (41%)
Hrb87F	NP_001163602.1	RRM_SF	116..188	CDD:302621	28/71 (39%)
HNRNPAB	NP_112556.2	CBFNT	1..70	CDD:311868	5/18 (28%)
		RRM1_hnRNPAB	66..145	CDD:410151	31/78 (40%)
		RRM2_hnRNPAB	150..229	CDD:409997	32/85 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920