DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb87F and HNRNPA1

DIOPT Version :9

Sequence 1:	NP_001163602.1	Gene:	Hrb87F / 48535	FlyBaseID:	FBgn0004237	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_112420.1	Gene:	HNRNPA1 / 3178	HGNCID:	5031	Length:	372	Species:	Homo sapiens

Alignment Length:	391	Identity:	194/391 - (49%)
Similarity:	246/391 - (62%)	Gaps:	46/391 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EEITEPEQLRKLFIGGLDYRTTDDGLKAHFEKWGNIVDVVVMKDPKTKRSRGFGFITYSQSYMID 79
            |...|||||||||||||.:.|||:.|::|||:||.:.|.|||:||.|||||||||:||:....:|
Human     5 ESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVD 69

  Fly    80 NAQNARPHKIDGRTVEPKRAVPRQEIDSPNAGATVKKLFVGGLRDDHDEECLREYFKDFGQIVSV 144
            .|.||||||:|||.|||||||.|::...|.|..||||:||||:::|.:|..||:||:.:|:|..:
Human    70 AAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVI 134

  Fly   145 NIVSDKDTGKKRGFAFIEFDDYDPVDKIILQKTHSIKNKTLDVKKAIAKQDM-----DRQG--GG 202
            .|::|:.:||||||||:.|||:|.||||::||.|::.....:|:||::||:|     .::|  |.
Human   135 EIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGS 199

  Fly   203 GGRGGPRAGGRGGQGDRGQGG-----GGWGGQNRQNGGGNWGGAGGG-GGFGNSGGNFGGGQG-- 259
            |..||.|.||.||..:.|:||     ||:||   ..|||.:||:|.| .||||.||..|||.|
Human   200 GNFGGGRGGGFGGNDNFGRGGNFSGRGGFGG---SRGGGGYGGSGDGYNGFGNDGGYGGGGPGYS 261

  Fly   260 GGSGGWNQQGGSGGGPWNNQGGGNGG------WNGGGGGGYGGGNSNGSWGGNGGGGGGGGGFGN 318
            |||.|:    ||||..:.|||.|.||      :|.|||||:|||:     |.|.||||....|||
Human   262 GGSRGY----GSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGS-----GSNFGGGGSYNDFGN 317

  Fly   319 EYQQSYGGGPQRNSNFGNNRPAPYSQGGGGGGFNK-GNQGGGQGFAGNNYNTGGGGQGGNMGGGN 382
            ...||...||.:..|||.....||  ||||..|.| .||||          .||.....:.|.|.
Human   318 YNNQSSNFGPMKGGNFGGRSSGPY--GGGGQYFAKPRNQGG----------YGGSSSSSSYGSGR 370

  Fly   383 R 383
            |
Human   371 R 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb87F	NP_001163602.1	RRM1_hnRNPA_like	25..102	CDD:241022	51/76 (67%)
Hrb87F	NP_001163602.1	RRM_SF	116..188	CDD:302621	34/71 (48%)
HNRNPA1	NP_112420.1	Globular A domain	4..94		59/88 (67%)
		RRM1_hnRNPA1	12..92	CDD:410154	54/79 (68%)
		Globular B domain	95..185		43/89 (48%)
		RRM2_hnRNPA3	105..184	CDD:409996	38/78 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..216		13/33 (39%)
		RNA-binding RGG-box	218..240		10/24 (42%)
		HnRNPA1	307..344	CDD:402981	17/38 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..372		25/67 (37%)
		Nuclear targeting sequence (M9)	320..357		19/48 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6828
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	360	1.000	Inparanoid score	I2209
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46466
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103644
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.780