DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb87F and RBMX

DIOPT Version :9

Sequence 1:	NP_001163602.1	Gene:	Hrb87F / 48535	FlyBaseID:	FBgn0004237	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_002130.2	Gene:	RBMX / 27316	HGNCID:	9910	Length:	391	Species:	Homo sapiens

Alignment Length:	413	Identity:	97/413 - (23%)
Similarity:	135/413 - (32%)	Gaps:	155/413 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 EIDSPNAGATVKKLFVGGLRDDHDEECLREYFKDFGQIVSVNIVSDKDTGKKRGFAFIEFDDYDP 168
            |.|.|.      |||:|||..:.:|:.|...|..:|:||.|.::.|::|.|.|||||:.|:  .|
Human     3 EADRPG------KLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFE--SP 59

  Fly   169 VDKIILQKTHSIKNKTLDVKKAIAKQDMDRQGGGGGRGGP------RAGGRGGQGDRGQGGGGWG 227
            .|  .......:..|:|| .|||..:...:.....||.||      |...||.:|.||..||..|
Human    60 AD--AKDAARDMNGKSLD-GKAIKVEQATKPSFESGRRGPPPPPRSRGPPRGLRGGRGGSGGTRG 121

  Fly   228 GQNRQNGGGNWGGAGGGGGFGNSGG---NFGGGQGGG-----------SGGWNQQGGSGGGPWNN 278
            ..:|             ||..:.||   ||......|           |||...:..:..||..:
Human   122 PPSR-------------GGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGPPPKRSAPSGPVRS 173

  Fly   279 QGGGNG------GWNGGGG---------------------------------------------- 291
            ..|..|      |.:..||
Human   174 SSGMGGRAPVSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPP 238

  Fly   292 -----GGYGGGNSNGSWGGNGGGGGGGGGFGNEYQQSYGGGPQRNS--NFGNNRPAPYSQGG--- 346
                 ..||..:|...:...|.....|.|...:|.....||..|:|  ::||:|.||.::|.
Human   239 RDYTYRDYGHSSSRDDYPSRGYSDRDGYGRDRDYSDHPSGGSYRDSYESYGNSRSAPPTRGPPPS 303

  Fly   347 -GGGGFNKGNQGGGQGFAGNN----------YNTG------------------------------ 370
             ||............|:.|:.          |::|
Human   304 YGGSSRYDDYSSSRDGYGGSRDSYSSSRSDLYSSGRDRVGRQERGLPPSMERGYPPPRDSYSSSS 368

  Fly   371 -----GGGQGG---NMGGGNRRY 385
                 |||:||   :.|||..||
Human   369 RGAPRGGGRGGSRSDRGGGRSRY 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb87F	NP_001163602.1	RRM1_hnRNPA_like	25..102	CDD:241022
Hrb87F	NP_001163602.1	RRM_SF	116..188	CDD:302621	27/71 (38%)
RBMX	NP_002130.2	RRM_RBMX_like	7..86	CDD:409816	31/89 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..391		69/345 (20%)
		dnaA	165..>306	CDD:237605	24/140 (17%)
		RBM1CTR	173..217	CDD:400429	5/43 (12%)
		Necessary for the association to nascent RNAPII transcripts and nuclear localization	186..236		3/49 (6%)
		Necessary for RNA-binding	333..391		10/57 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910