DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrb87F and TARDBP

DIOPT Version :9

Sequence 1:	NP_001163602.1	Gene:	Hrb87F / 48535	FlyBaseID:	FBgn0004237	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_031401.1	Gene:	TARDBP / 23435	HGNCID:	11571	Length:	414	Species:	Homo sapiens

Alignment Length:	321	Identity:	104/321 - (32%)
Similarity:	142/321 - (44%)	Gaps:	35/321 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LFIGGLDYRTTDDGLKAHFEKWGNIVDVVVMKDPKTKRSRGFGFITYSQSYMIDNAQNARPHKID 90
            |.:.||.::||:..||.:|..:|.::.|.|.||.||..|:||||:.::: |.......::.|.||
Human   106 LIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTE-YETQVKVMSQRHMID 169

  Fly    91 GRTVEPKRAVPRQEIDSPNAGATVKKLFVGGLRDDHDEECLREYFKDFGQIVSVNIVSDKDTGKK 155
            ||..:.|....:|..|.|   ...:|:|||...:|..|:.|||:|..:|.::.|.|..     ..
Human   170 GRWCDCKLPNSKQSQDEP---LRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPK-----PF 226

  Fly   156 RGFAFIEFDDYDPVDKIILQKTHSIKNKTLDVKKAIAKQDMDRQGGGGGRGGPRAGGRGGQGDRG 220
            |.|||:.|.| |.:.:.:..:...||..::.:..|..|.:.:||....||.|...||.|.||..|
Human   227 RAFAFVTFAD-DQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFG 290

  Fly   221 QGGGGWGGQNRQNGGGNWGGAGGGGGFGNSGGNFGGGQGGGSGGW----------NQQGGSGGGP 275
            ...||..|.. .|.|.|.||....|.|..:.......|......|          ||.|.||
Human   291 NSRGGGAGLG-NNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG--- 351

  Fly   276 WNNQGGGN-----GGWNGGGGGGYGGGNSNGS--WG--GNGGGGGG-GGGFGNEYQQSYGG 326
             |||..||     ....|.|...|.|.||..:  ||  .|.|.|.| .||||:.......|
Human   352 -NNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSG 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrb87F	NP_001163602.1	RRM1_hnRNPA_like	25..102	CDD:241022	27/75 (36%)
Hrb87F	NP_001163602.1	RRM_SF	116..188	CDD:302621	22/71 (31%)
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:376118
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:18957508	82..98
		RRM1_TDP43	105..181	CDD:240767	27/75 (36%)
		RRM2_TDP43	191..261	CDD:240768	22/75 (29%)
		Interaction with UBQLN2. /evidence=ECO:0000269\|PubMed:23541532	216..414		63/207 (30%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:18957508	239..250		0/10 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..303		15/42 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..373		12/35 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910