DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpY-55A and PPP3CB

DIOPT Version :9

Sequence 1:	NP_001286554.1	Gene:	PpY-55A / 48532	FlyBaseID:	FBgn0003140	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_001135825.1	Gene:	PPP3CB / 5532	HGNCID:	9315	Length:	525	Species:	Homo sapiens

Alignment Length:	314	Identity:	109/314 - (34%)
Similarity:	175/314 - (55%)	Gaps:	33/314 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 THEIDCIIKELTSLNG------------SECTLKEELIERLIQQTREVIKWQPMLLELQAPVNIC 58
            ||.:..  :|:..|:|            .|..:.||:..|:|.:...:::.:..::|::||:.:|
Human    35 THRLTS--EEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVC 97

  Fly    59 GDIHGQFTDLLRIFKACGFPPKANYLFLGDYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHES 123
            |||||||.||:::|:..|.|....|||||||||||..|:|.:..|:..|:.||...||||||||.
Human    98 GDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHEC 162

  Fly   124 ASINKIYGFYDEIKRRHTVRLWHSFTDCFNWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRP 188
            ..:.:.:.|..|.|.:::.|::.:..:.|:.||:|||:.::..|.||||||.:..|..|..:.|.
Human   163 RHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRF 227

  Fly   189 TDIPDEGIMCDLLWADLNH------TTKGWGHND-RGVSFTFDKVIVRDFLKAFDLQLMVRAHEV 246
            .:.|..|.||||||:|.:.      :.:.:.||. ||.|:.::...|.:||:..:|..::||||.
Human   228 KEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEA 292

  Fly   247 VEDGYEFFANRQ------LVTVFSAPNYCGMMNNAGGVMSVSTDLI------CS 288
            .:.||..:...|      |:|:||||||..:.||...|:....:::      ||
Human   293 QDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCS 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpY-55A	NP_001286554.1	PTZ00480	8..310	CDD:185658	107/312 (34%)
PpY-55A	NP_001286554.1	MPP_PP1_PPKL	8..294	CDD:277359	107/312 (34%)
PPP3CB	NP_001135825.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		MPP_PP2B	50..354	CDD:277361	104/297 (35%)
		Catalytic. /evidence=ECO:0000305	65..356		103/282 (37%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	316..320		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:26794871	357..379
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:26794871	402..416
		Autoinhibitory segment. /evidence=ECO:0000269\|PubMed:26794871	417..424
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:26794871	475..497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820