DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PpY-55A and Ppp3cc

DIOPT Version :9

Sequence 1:	NP_001286554.1	Gene:	PpY-55A / 48532	FlyBaseID:	FBgn0003140	Length:	314	Species:	Drosophila melanogaster
Sequence 2:	NP_001291920.1	Gene:	Ppp3cc / 19057	MGIID:	107162	Length:	522	Species:	Mus musculus

Alignment Length:	336	Identity:	111/336 - (33%)
Similarity:	177/336 - (52%)	Gaps:	48/336 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ECTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLG 87
            |..::||:..::|.....::|.:..::|::||:.:|||:||||.||:::|:..|.|....|||||
Mouse    49 EGRVEEEVALKIINDGAAILKQEKTMIEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLG 113

  Fly    88 DYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYGFYDEIKRRHTVRLWHSFTDCF 152
            ||||||..|:|.:..|::.|:.:|...||||||||...:.:.:.|..|.:.:::..::.:....|
Mouse   114 DYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTEYFTFKQECRIKYSEMVYDACMHTF 178

  Fly   153 NWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWAD----------LNH 207
            :.||:|||:.::..|.|||:||.:..|:.|..:.|.::.|..|.:|||||:|          |.|
Mouse   179 DCLPLAALLNQQFLCVHGGMSPEITCLEDIRKLDRFSEPPAFGPVCDLLWSDPLEDYGSEKTLEH 243

  Fly   208 TTKGWGHND-RGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQ------LVTVFSA 265
            .|    ||. ||.|:.|....|.:||:...|..::||||..:.||..:...|      |:|:|||
Mouse   244 YT----HNTVRGCSYFFSYPAVCEFLQNNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSA 304

  Fly   266 PNYCGMMNNAGGVMSVSTDLI------CS------------FVIILPCHKYKM---------IAT 303
            |||..:.||...|:....:::      ||            |...||....|:         |.:
Mouse   305 PNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICS 369

  Fly   304 DANQMPTNEEE 314
            |.....|:||:
Mouse   370 DEEMNVTDEED 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PpY-55A	NP_001286554.1	PTZ00480	8..310	CDD:185658	108/330 (33%)
PpY-55A	NP_001286554.1	MPP_PP1_PPKL	8..294	CDD:277359	103/305 (34%)
Ppp3cc	NP_001291920.1	MPP_PP2B	37..341	CDD:277361	102/295 (35%)
		Catalytic. /evidence=ECO:0000305	52..343		101/294 (34%)
		PP2Ac	54..325	CDD:197547	99/274 (36%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250\|UniProtKB:P16298	344..366		4/21 (19%)
		Calmodulin-binding. /evidence=ECO:0000250\|UniProtKB:P16298	394..408
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	409..416
		Autoinhibitory domain. /evidence=ECO:0000250\|UniProtKB:P16298	467..489
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820