Protein Alignment PpY-55A and Ppp3ca

DIOPT Version :10

• Sequence 1: NP_476689.1
• Gene: PpY-55A / 48532
• FlyBaseID: FBgn0003140
• Length: 314
• Species: Drosophila melanogaster
• Sequence 2: NP_032939.1
• Gene: Ppp3ca / 19055
• MGIID: 107164
• Length: 521
• Species: Mus musculus
• Alignment Length: 285
• Identity: 109/285 - (38%)
• Similarity: 164/285 - (57%)
• Gaps: 19/285 - (6%)

  Fly    23 ECTLKEELIERLIQQTREVIKWQPMLLELQAPVNICGDIHGQFTDLLRIFKACGFPPKANYLFLG 87
            |..|:|.:..|:|.:...:::.:..||::.|||.:||||||||.||:::|:..|.|....|||||
Mouse    53 EGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLG 117

  Fly    88 DYVDRGKQSLETICLLFAYKVKYPLNFFLLRGNHESASINKIYGFYDEIKRRHTVRLWHSFTDCF 152
            ||||||..|:|.:..|:|.|:.||...||||||||...:.:.:.|..|.|.:::.|::.:..|.|
Mouse   118 DYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAF 182

  Fly   153 NWLPVAALVGERIFCCHGGLSPSLRNLQQINHIQRPTDIPDEGIMCDLLWAD------LNHTTKG 211
            :.||:|||:.::..|.||||||.:..|..|..:.|..:.|..|.|||:||:|      ...|.:.
Mouse   183 DCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEH 247

  Fly   212 WGHND-RGVSFTFDKVIVRDFLKAFDLQLMVRAHEVVEDGYEFFANRQ------LVTVFSAPNYC 269
            :.||. ||.|:.:....|.|||:..:|..::||||..:.||..:...|      |:|:||||||.
Mouse   248 FTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYL 312

  Fly   270 GMMNNAGGVMSVSTDLI------CS 288
            .:.||...|:....:::      ||
Mouse   313 DVYNNKAAVLKYENNVMNIRQFNCS 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PpY-55A	NP_476689.1	MPP_PP1_PPKL	8..294	CDD:277359	109/285 (38%)
Ppp3ca	NP_032939.1	MPP_PP2B	41..345	CDD:277361	109/285 (38%)
		Catalytic. /evidence=ECO:0000305	56..340		108/282 (38%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000250|UniProtKB:Q08209	327..336		0/8 (0%)
		Calcineurin B binding. /evidence=ECO:0000269|PubMed:26794871	341..369
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:26794871	392..406
		Autoinhibitory segment. /evidence=ECO:0000269|PubMed:26794871	407..414
		Autoinhibitory domain. /evidence=ECO:0000269|PubMed:26794871	465..487
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..521