DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pp1-13C and PPP3CC

DIOPT Version :9

Sequence 1:NP_524921.1 Gene:Pp1-13C / 48531 FlyBaseID:FBgn0003132 Length:302 Species:Drosophila melanogaster
Sequence 2:NP_001230903.1 Gene:PPP3CC / 5533 HGNCID:9316 Length:521 Species:Homo sapiens


Alignment Length:294 Identity:114/294 - (38%)
Similarity:176/294 - (59%) Gaps:30/294 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 KNVQLSEGEI-RGLCLK----SREILLAQPILLELEAPLKICGDIHGQYYDLLRLFEYGGYPPEA 83
            ||..:.||.: ..:.||    ...||..:..::|::||:.:|||||||::||::|||.||.|...
Human    43 KNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNT 107

  Fly    84 NYLFLGDYVDRGKQSLETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYTIKLWK 148
            .|||||||||||..|:|.:..|.:.||.:.:..|||||||||..:...:.|..||:.:|:.:::.
Human   108 RYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYD 172

  Fly   149 TFTDCFNCLPVVAIVDEKIFCCHGGLSPDLTSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDTIG 213
            ...:.|:|||:.|:::::..|.|||:||::||::.||::.|.|:.|..|.:||||||||.:|   
Human   173 ACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSED--- 234

  Fly   214 WGEND----------RGVSFTFGAEVVVKFLQKHDLDLICRAHQVVEDGYEFFAKRQ------LV 262
            :|...          ||.|:.:....|.:|||.::|..|.|||:..:.||..:.|.|      |:
Human   235 YGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLI 299

  Fly   263 TLFSAPNYCGEFDNAGAMMSVDNTLM------CS 290
            |:||||||...::|..|::..:|.:|      ||
Human   300 TIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCS 333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pp1-13CNP_524921.1 PTZ00480 5..299 CDD:185658 114/294 (39%)
MPP_PP1_PPKL 6..296 CDD:277359 114/294 (39%)
PPP3CCNP_001230903.1 MPP_PP2B 37..341 CDD:277361 114/294 (39%)
Catalytic. /evidence=ECO:0000305 52..343 110/285 (39%)
PP2Ac 54..325 CDD:197547 107/273 (39%)
SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209 303..307 3/3 (100%)
Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298 344..366
Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298 395..409
Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298 410..417
Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298 468..490
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 480..521
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0639
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53795
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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