DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pp1-13C and PPEF1

DIOPT Version :9

Sequence 1:	NP_524921.1	Gene:	Pp1-13C / 48531	FlyBaseID:	FBgn0003132	Length:	302	Species:	Drosophila melanogaster
Sequence 2:	NP_001364915.1	Gene:	PPEF1 / 5475	HGNCID:	9243	Length:	653	Species:	Homo sapiens

Alignment Length:	332	Identity:	98/332 - (29%)
Similarity:	153/332 - (46%)	Gaps:	81/332 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KSREILLAQPILLELE-APLK---ICGDIHGQYYDLLRLFEYGGYPPEAN-YLFLGDYVDRGKQS 98
            :::::|...|....:: :|.|   ||||:||:..||..:|...|.|.|.| |:|.||:|||||.|
Human   145 ETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNGDFVDRGKNS 209

  Fly    99 LETICLLLAYKIKYSENFFLLRGNHECASINRIYGFYDECKRRYTI---KLWKTFTDCFNCLPVV 160
            :|.:.:|....:.|..:..|.|||||...:|..|||..|...:|.:   ::.:...:.:..||:.
Human   210 IEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRILQILEEFYAWLPIG 274

  Fly   161 AIVDEKIFCCHGGLS--PDLTSMEQIRR------IMRPTDV------------------------ 193
            .|||.:|...|||:|  .||..:.::.|      ::.||:.
Human   275 TIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHDTDSKHNKVGVTFNAHGRIK 339

  Fly   194 ----PDQGL-------LCDLLWSDPDKDTIGWGEND------RGVSFTFGAEVVVKFLQKHDLDL 241
                |.:.|       :.|:|||||.      |:|.      ||....||.:|..|.|.|:.|.:
Human   340 TNGSPTEHLTEHEWEQIIDILWSDPR------GKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKM 398

  Fly   242 ICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDNTLMCS--------FQILK--- 295
            :.|:|:...:|||.....::||:|||.||..|..|.||.:.     :||        :|:.|
Human   399 LIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGAYIK-----LCSGTTPRFFQYQVTKATC 458

  Fly   296 --PVEKR 300
              |:.:|
Human   459 FQPLRQR 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp1-13C	NP_524921.1	PTZ00480	5..299	CDD:185658	97/329 (29%)
Pp1-13C	NP_524921.1	MPP_PP1_PPKL	6..296	CDD:277359	96/326 (29%)
PPEF1	NP_001364915.1	IQ	18..37	CDD:197470
		MPP_RdgC	115..452	CDD:277364	94/317 (30%)
		Catalytic	121..455		95/320 (30%)
		EF-hand_7	568..636	CDD:404394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810