DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NOTCH2 and ASP3-2

DIOPT Version :9

Sequence 1:NP_077719.2 Gene:NOTCH2 / 4853 HGNCID:7882 Length:2471 Species:Homo sapiens
Sequence 2:NP_013258.1 Gene:ASP3-2 / 850852 SGDID:S000004147 Length:362 Species:Saccharomyces cerevisiae


Alignment Length:255 Identity:53/255 - (20%)
Similarity:77/255 - (30%) Gaps:84/255 - (32%)


- Green bases have known domain annotations that are detailed below.


Human  1799 IRRTPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLV 1863
            |...||||     .:..:|.|.|:..|.:......|..|..|.|:....|:              
Yeast    67 IEAVPSLA-----EKANLDYLQVSNVGSNSLNYTHLIPLYHGISEALASDD-------------- 112

Human  1864 YQGASLQAQTDRTGEMALHL-----------------AARYSRADAAKRLLDAGADANAQDNMGR 1911
            |.||.:...||...|.|..|                 .|..:.||....|..|.:.|.::.::||
Yeast   113 YAGAVVTHGTDTMEETAFFLDLTINSEKPVCIAGAMRPATATSADGPMNLYQAVSIAASEKSLGR 177

Human  1912 ---CPLHAAVA-----------------ADAQGVFQILIRNRVT--------------DLDARMN 1942
               ..|:..:|                 ||.||.......:.|.              |:....:
Yeast   178 GTMITLNDRIASGFWTTKMNANSLDTFRADEQGYLGYFSNDDVEFYYPPVKPNGWQFFDISNLTD 242

Human  1943 DGTTPLILAARLAVEGMVAELINCQADVNAVDD--------HGKSALHWAAAVNNVEATL 1994
            ....|.::.. .:.:|:..|||     |.||.|        .|..|..|.|..:.|...|
Yeast   243 PSEIPEVIIL-YSYQGLNPELI-----VKAVKDLGAKGIVLAGSGAGSWTATGSIVNEQL 296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH2NP_077719.2 EGF_CA 182..218 CDD:238011
EGF_CA 260..296 CDD:238011
EGF_CA 298..335 CDD:238011
EGF_CA 415..454 CDD:238011
EGF_CA 456..492 CDD:238011
EGF_CA 495..530 CDD:238011
EGF_CA 532..568 CDD:238011
EGF_CA 570..604 CDD:238011
EGF_CA 608..643 CDD:238011
EGF_CA 645..679 CDD:238011
EGF_CA 682..717 CDD:238011
EGF_CA 757..793 CDD:238011
EGF_CA 795..831 CDD:238011
EGF_CA 873..909 CDD:238011
EGF_CA 911..947 CDD:238011
EGF_CA 949..985 CDD:238011
EGF_CA 987..1022 CDD:238011
EGF_CA 1026..1061 CDD:238011
EGF_CA 1117..1147 CDD:238011
EGF_CA 1151..1185 CDD:238011
EGF_CA 1188..1223 CDD:238011
EGF_CA 1225..1262 CDD:238011
EGF_CA 1264..1302 CDD:238011
EGF_CA <1312..1343 CDD:238011
Notch 1423..1456 CDD:278494
Notch 1463..1497 CDD:278494
Notch 1501..1534 CDD:278494
NOD 1540..1591 CDD:284282
NODP 1620..1673 CDD:284987
Ank_2 <1820..1907 CDD:289560 21/103 (20%)
ANK repeat 1827..1874 CDD:293786 8/46 (17%)
ANK 1872..1997 CDD:238125 36/182 (20%)
ANK repeat 1877..1907 CDD:293786 9/46 (20%)
Ank_2 1881..1974 CDD:289560 24/143 (17%)
ANK 1938..2062 CDD:238125 15/65 (23%)
ANK repeat 1943..1974 CDD:293786 7/30 (23%)
Ank_2 1948..2040 CDD:289560 14/55 (25%)
ANK repeat 1976..2007 CDD:293786 6/19 (32%)
ANK repeat 2009..2040 CDD:293786
Chorion_3 <2292..2421 CDD:253174
DUF3454 2381..2444 CDD:288764
ASP3-2NP_013258.1 asnASE_II 9..359 CDD:273115 53/255 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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