DRSC/TRiP Functional Genomics Resources

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Protein Alignment NOTCH2 and notch2

DIOPT Version :10

Sequence 1:NP_077719.2 Gene:NOTCH2 / 4853 HGNCID:7882 Length:2471 Species:Homo sapiens
Sequence 2:NP_001108566.2 Gene:notch2 / 58065 ZFINID:ZDB-GENE-000329-4 Length:2475 Species:Danio rerio


Alignment Length:2535 Identity:1392/2535 - (54%)
Similarity:1720/2535 - (67%) Gaps:170/2535 - (6%)


- Green bases have known domain annotations that are detailed below.


Human    12 LLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNG 76
            ::.|.:|....::||||.|..:|||| |.||...|||.||:|..|||||||.|.|||....|:||
Zfish    12 VILLLICFLKTSYALQCIDHEKPCVN-GTCVISSNGTHYCRCAPGFLGEYCHHSDPCNLLYCKNG 75

Human    77 GTCVAQ--AMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTG 139
            |.|...  .:.|..:|.|..||.||.|:...:..|:.:.||.|||.|.:|..|.|:|.|.:|:||
Zfish    76 GECKVSVAGVPGSPSCVCPLGFAGEHCEIQKNSTCYPNNPCTNGGKCLLLPNDQYKCQCALGWTG 140

Human   140 KECQWTDACLSHPCANGSTCTTVAN-QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPG 203
            :.|:..|||||.||||...|..:.| ::||.|..||.|.:|..|.:||..|..|::.|.|:|..|
Zfish   141 QHCEQEDACLSSPCANKGICNALPNREYSCTCAPGFHGSRCLNDTDECVDPLVCKNKGVCVNTIG 205

Human   204 SYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHR 268
            ||:|.|..||||..|.|.|.||:||||.||||||||.:.|:.|:|||||.|:.||.||||||:||
Zfish   206 SYRCNCQPGFTGLDCGSPYFPCSPSPCQNGGTCRQTTETTYVCHCLPGFNGTNCEVNIDDCPDHR 270

Human   269 CQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGD 333
            ||||..|:||||||||:|||:|||||||:|||||.||||||||||||:|...||.|||||||||.
Zfish   271 CQNGATCMDGVNTYNCQCPPEWTGQFCTDDVDECRLQPNACQNGGTCSNTRNGYNCVCVNGWSGL 335

Human   334 DCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQ 398
            ||||||||||...||.|||||||||||.|.||.||.|||||:|||||||||..||.|||||:||:
Zfish   336 DCSENIDDCAAEPCTAGSTCIDRVASFVCSCPPGKTGLLCHIDDACISNPCKMGAHCDTNPVNGK 400

Human   399 YICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSD 463
            :.|.||.||||:.|.||:|||.: ..|||||.|.|.||:|:|.|.|..||.|||||.|||||.|:
Zfish   401 FSCNCPSGYKGSTCAEDIDECVI-GPNPCEHGGSCKNTEGSFTCNCAPGYTGPRCEQDINECGSN 464

Human   464 PCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPV 528
            ||||||||||:||.:||:|||||.|.|||.:||||.|:||:|||:|:|:|:||.|.||.||||..
Zfish   465 PCQNDATCLDQIGDYTCICMPGFDGTHCENDINECLSSPCLNNGRCLDQVSRFVCECPQGFTGET 529

Human   529 CQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTC 593
            ||:|||:|:||||.|||||:|.||||||:||.||||.||.|||::|:|.|||||:|.|||.::.|
Zfish   530 CQVDIDECASTPCHNGAKCLDRPNGYECECAEGFTGPLCMENINDCEPQPCHHGKCIDGIATFHC 594

Human   594 ICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGI 658
            .|.|||||.|||:||.||.|.||.|.|||:|:||.|||||||||:|.||:||:||||||||.||.
Zfish   595 DCLPGYMGPICSEQIRECQSDPCQNGGRCVDMVNRYQCNCQPGTAGENCQINYDDCASNPCQHGT 659

Human   659 CMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNE 723
            |.||||.|.|||.||:||:||..:|:||:||||:.|.||.:.||||:|.||.|.:.|.|.|..:.
Zfish   660 CEDGINEYKCVCEPGYTGERCADEINECSSNPCQSGGTCEDKVNGFKCKCPVGTYGPLCLSGADR 724

Human   724 CLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFK 788
            |:..||.||.|.|...||.|.|:.||.|.||:.:|||||||||||||||::.:|.|.|.|.:||.
Zfish   725 CIRMPCRHGECIGKQEGYLCQCEPGWEGTNCDQEKNECLSNPCQNGGTCNDRLNDYTCVCARGFA 789

Human   789 GYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPN 853
            |:||::||:||.||||:|||||.|.::.|.|||..|||||:|...|.||:..||:...||:.|.:
Zfish   790 GFNCEININECESNPCMNQGTCVDGVNSYVCHCKPPYTGKHCLEKLIPCASQPCQRRGVCQPSLD 854

Human   854 FESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLAN 918
            :.||||.|..||:|.:||.|.|||...||.|...|.|..|||.||||||:||.:|:.:||||.:|
Zfish   855 YTSYTCKCHSGWEGAQCTEDKDECKKSPCQNGARCVNIVGSYRCECPPGYSGDNCQTNIDDCSSN 919

Human   919 PCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVH 983
            ||:|||:|:|.|..:.|.|..||.|::|:.:::||.|.||.|||.|:||||||||:|..|:||::
Zfish   920 PCRNGGTCVDKVGRYLCECRAGFYGERCEEEVDECASNPCWNGGHCTDYVNSYTCQCPPGYDGIN 984

Human   984 CENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYR 1048
            ||.:|.:|||:||.|.||||||||.|||.|..||:|.:|..|:|||.||||.|.|||:|||||:.
Zfish   985 CERDIPDCTETSCLNNGTCVDGINHFSCRCRQGFSGQYCQFELNECDSHPCKNGGTCIDGLGTFH 1049

Human  1049 CSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRG 1113
            |:|||.|.||.|:::|||||:..|:|.|||:||:...:|.|..||.|.|||:|::||...|..:|
Zfish  1050 CNCPLMYNGKTCESMVNLCSQIKCQNGGTCIQKEINWRCSCQPGWTGLYCDIPSMSCHAVALNKG 1114

Human  1114 VLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPG 1178
            |....:|:|:|.|.|.||||.|:|..||||||||.::|||.|:||::|.||.|:.|||.|:|..|
Zfish  1115 VAENMVCKHAGHCKNIGNTHQCECQKGYTGSYCETEIDECLSSPCRNGGTCVDYQGGYDCKCKAG 1179

Human  1179 YQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCAR--GPHCLNGGQC 1241
            :|||||||.|:|||:.||:||||||||:|||.|||||||:||.||.::|:||.  ||.|.|||||
Zfish  1180 FQGVNCEYNVNECQSNPCRNGGTCIDLINHFSCSCPPGTKGLQCEVDVDECAPEFGPRCKNGGQC 1244

Human  1242 MDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVD 1306
            :|.:|.|:|.|.||||||.||||:|||.|.||.|.|::||:.|.|.|.|.||..:||:.||:.||
Zfish  1245 VDGVGRYTCNCPPGFAGEHCEGDVNECRSGPCYSPGTIDCVPLINSYQCRCRLGYTGQRCESMVD 1309

Human  1307 VCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQS----SCGQVKCRKGEQCVHTASGPRCF 1367
            :|...||.|.|.|...|:...|:||.|||||||..|.:    .|..::|..|.|||...|.|:|.
Zfish  1310 LCQSKPCHNNGRCTTNSSSVHGYICTCPPGFSGFNCGNYEMFPCASLRCLNGGQCVEIKSRPQCH 1374

Human  1368 CP---SPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQY 1429
            ||   :...||.......||:||:|.|. :...:||:|.|.|||..|:      .||| :|....
Zfish  1375 CPVGFTGTHCEMLTNHCVCQNGGTCMPD-ESNKFSCRCPPGFSGETCQ------ETPP-SCPYPD 1431

Human  1430 CADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWD-YINNQCDELCNTVECLFDN 1493
            |..:|.|.|||..|.:..|.|||.||:|..:.||.||.:.:.|.| :.|.:||..||...||||:
Zfish  1432 CEQRAGDKVCDLRCKNPECDWDGSDCTLHWDKPWKNCKASVSCPDLFHNGRCDPECNNAGCLFDS 1496

Human  1494 FECQGNSKT--CKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPE 1556
            |||..:|..  ||||||||||:.:.||:||||:|.|||||||||.|.|..||.||||||||:.|:
Zfish  1497 FECDKHSSVGICKYDKYCADHYANGHCNQGCNTEACGWDGLDCARDTPPKLANGTLVIVVLLQPK 1561

Human  1557 QLLQDARSFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKS-------AAMKKQRMTRRSLPGEQ 1614
            :||.|.:.|||:|||||||||::|.|...:|||||:|..:.       ||| |||..|     |.
Zfish  1562 ELLADLKGFLRSLGTLLHTNLQVKLDEHNKLMVYPFYRNEQNEIQNEIAAM-KQRGKR-----EL 1620

Human  1615 EQEVAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPERT--Q 1677
            |.|:.||:|.||||||.|.|:||.|..:.|.|||.:|:..::..|.||:.|:.::  .|:.|  .
Zfish  1621 ENEIIGSRVHLEIDNRLCTQNSDECISSADQAAAFIAAEYLKSDLPYPIYSITTK--PPKETGFN 1683

Human  1678 LLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSV 1742
            .|||:|||..|||.|::|||:.||||||||:||||:||...:::   |||||||||..|:|::. 
Zfish  1684 FLYLVAVAAAIILLILVLGVLAAKRKRKHGTLWLPDGFLPNKES---KRREPVGQDDFGMKSMQ- 1744

Human  1743 QVSEANLIGTGTSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLAL 1807
            :..:..|:...::.|| .:|...|||.:.||:.||....|.:|||.||.||.:||||      .|
Zfish  1745 KPQDGGLLDCSSNHHW-SEEDHLPKKPRMEDKPLLPVGVDGVDRREWTLQHHKAADI------TL 1802

Human  1808 TPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSD-----LSDEDED--AEDSSANIITDLVYQ 1865
            |||||:.:::.|||||:||||.|||||||||.|||.     |.:|:|:  |::...|:||||:.|
Zfish  1803 TPPQADNDMESLDVNVKGPDGFTPLMLASLRNGSSPDCGSMLGEEEEESGADEPGTNVITDLIGQ 1867

Human  1866 GASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILI 1930
            ||||.||||||||.||||||||:|||||||||||||||||.|||||.||||||||||||||||||
Zfish  1868 GASLNAQTDRTGETALHLAARYARADAAKRLLDAGADANAHDNMGRTPLHAAVAADAQGVFQILI 1932

Human  1931 RNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLL 1995
            |||.||||||||||||||||:|||||||||.||::|.|||||||||||||||||||||||:|||:
Zfish  1933 RNRATDLDARMNDGTTPLILSARLAVEGMVEELVHCHADVNAVDDHGKSALHWAAAVNNVDATLV 1997

Human  1996 LLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVR 2060
            |||||||||||||||||||||||||||:|||:|||||::|||||||:||||||.|::||||||||
Zfish  1998 LLKNGANRDMQDNKEETPLFLAAREGSFEAAQILLDHYSNRDITDHLDRLPRDTAQERMHHDIVR 2062

Human  2061 LLDEYNVTPSP---PGTVLT-SALSPVICGPNRS--FLSLKHTPMGKKSRRPSAKSTMPTSLPNL 2119
            ||||||:..||   |..|.. ...|.::||.|.:  .|.::..|.|||:||...|:....:  ..
Zfish  2063 LLDEYNLVHSPHSGPNHVGNGGGHSSMVCGTNGTGYILGMRPGPQGKKNRRAGGKANGVAA--GT 2125

Human  2120 AKEAKDAKGSRRKK-----------------SLSEKV-QLSESSVTLSPVDSLESPHTYVSD--T 2164
            ||:.|:.|..||||                 ::|... .|||||||:||||||||||:|..:  .
Zfish  2126 AKDLKEMKAKRRKKPTGGEGPSVVPVTTAGGNVSRAAGGLSESSVTMSPVDSLESPHSYAGEPVA 2190

Human  2165 TSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGASTVLPSVSQLLSHHH 2229
            |||...:.|.:...|..|||    ||.........|:..|.:.....|        :..|:.||.
Zfish  2191 TSSTANSPPLLSSQSARPML----PPVSHMLGQQQSWVGLSKHSYNGH--------MFSLMPHHQ 2243

Human  2230 IVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLAPAEGTHPGI-APQSRPPEGKH 2293
            :.:..||    :.:.|                                 .||: ||.       :
Zfish  2244 MSAGHSG----MQQHH---------------------------------SPGMSAPM-------N 2264

Human  2294 ITTPREPLPPIVTFQLIPKGS----IAQP-------AGAPQPQST---CPPAVAGPLPTM---YQ 2341
            :|..||.||||||||::|.||    :.||       .|..|||:.   |...:..|:|.:   :.
Zfish  2265 VTMSREQLPPIVTFQMMPTGSGQSLLKQPQQGQMQAQGQNQPQAQHLHCSQGMMYPIPDVSMQHS 2329

Human  2342 IPEMARLPSVAFPTAM---MPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAERTPS 2403
            :....:.||.|....:   :|  |||..|.:  :|.|..:.|.||||||||||||::.:...||.
Zfish  2330 LSHALQHPSHAHNHTLQHGLP--DGQARQVV--SYQPRQSPVDKYPTPPSQHSYATAGSEGTTPG 2390

Human  2404 HSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPPHNNMQ 2468
            |......|||||||||||||.||||||||.||||||||||||.| ......|..|...|....:|
Zfish  2391 HPAQKPSEHPYLTPSPESPDPWSSSSPHSNSDWSDVTTSPTPLG-NPHTMPPSCHTHIPEQAQLQ 2454

Human  2469  2468
            Zfish  2455  2454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH2NP_077719.2 EGF_CA 182..218 CDD:238011 17/35 (49%)
EGF_CA 260..296 CDD:238011 29/35 (83%)
EGF_CA 298..335 CDD:238011 29/36 (81%)
EGF_CA 415..454 CDD:238011 22/38 (58%)
EGF_CA 456..492 CDD:238011 27/35 (77%)
EGF_CA 495..530 CDD:238011 22/34 (65%)
EGF_CA 532..568 CDD:238011 27/35 (77%)
EGF_CA 570..604 CDD:238011 20/33 (61%)
EGF_CA 608..643 CDD:238011 24/34 (71%)
EGF_CA 645..679 CDD:238011 24/33 (73%)
EGF_CA 682..717 CDD:238011 19/34 (56%)
EGF_CA 757..793 CDD:238011 23/35 (66%)
EGF_CA 795..831 CDD:238011 23/35 (66%)
EGF_CA 873..909 CDD:238011 20/35 (57%)
EGF_CA 911..947 CDD:238011 18/35 (51%)
EGF_CA 949..985 CDD:238011 21/35 (60%)
EGF_CA 987..1022 CDD:238011 22/34 (65%)
EGF_CA 1026..1061 CDD:238011 23/34 (68%)
EGF_CA 1117..1147 CDD:238011 17/29 (59%)
EGF_CA 1151..1185 CDD:238011 20/33 (61%)
EGF_CA 1188..1223 CDD:238011 26/34 (76%)
EGF_CA 1225..1262 CDD:238011 22/38 (58%)
EGF_CA 1264..1302 CDD:238011 19/37 (51%)
EGF_CA <1312..1343 CDD:238011 16/30 (53%)
Notch 1423..1456 CDD:459658 13/32 (41%)
Notch 1463..1497 CDD:459658 16/34 (47%)
Notch 1501..1534 CDD:459658 23/34 (68%)
NOD 1539..1594 CDD:462014 34/54 (63%)
NODP 1618..1673 CDD:462229 23/54 (43%)
JMTM_Notch2 1659..1740 CDD:411986 44/82 (54%)
ANK repeat 1827..1874 CDD:293786 30/53 (57%)
ANKYR <1851..2066 CDD:440430 185/214 (86%)
ANK repeat 1877..1907 CDD:293786 27/29 (93%)
ANK repeat 1943..1974 CDD:293786 25/30 (83%)
ANK repeat 1976..2007 CDD:293786 28/30 (93%)
ANK repeat 2009..2040 CDD:293786 26/30 (87%)
DUF5585 2068..2422 CDD:465521 125/400 (31%)
notch2NP_001108566.2 EGF_CA 110..144 CDD:238011 15/33 (45%)
EGF_CA 184..220 CDD:238011 17/35 (49%)
EGF_CA 228..260 CDD:238011 20/31 (65%)
EGF_CA 262..298 CDD:238011 29/35 (83%)
EGF_CA 300..337 CDD:238011 29/36 (81%)
EGF_CA 340..375 CDD:238011 26/34 (76%)
EGF_CA 417..455 CDD:238011 22/38 (58%)
EGF_CA 457..493 CDD:238011 27/35 (77%)
EGF_CA 495..531 CDD:238011 22/35 (63%)
EGF_CA 533..568 CDD:238011 26/34 (76%)
EGF_CA 571..605 CDD:238011 20/33 (61%)
EGF_CA 609..644 CDD:238011 24/34 (71%)
EGF_CA 648..680 CDD:238011 23/31 (74%)
EGF_CA 684..718 CDD:238011 19/33 (58%)
EGF_CA 760..794 CDD:238011 22/33 (67%)
EGF_CA 796..831 CDD:238011 23/34 (68%)
EGF_CA 874..910 CDD:238011 20/35 (57%)
EGF_CA 912..948 CDD:238011 18/35 (51%)
EGF_CA 951..986 CDD:238011 21/34 (62%)
EGF_CA 988..1024 CDD:238011 22/35 (63%)
EGF_CA 1028..1062 CDD:238011 23/33 (70%)
EGF_CA 1151..1186 CDD:238011 20/34 (59%)
EGF_CA 1188..1224 CDD:238011 26/35 (74%)
EGF_CA 1226..1265 CDD:238011 22/38 (58%)
EGF_CA 1267..1305 CDD:238011 19/37 (51%)
EGF 1353..1381 CDD:394967 11/27 (41%)
NL 1420..1457 CDD:197463 16/43 (37%)
Notch 1465..1500 CDD:459658 16/34 (47%)
Notch 1508..1539 CDD:459658 23/30 (77%)
NOD 1544..1599 CDD:462014 34/54 (63%)
NODP 1624..1680 CDD:462229 24/57 (42%)
JMTM_Notch_APP 1665..1743 CDD:425406 44/82 (54%)
ANK repeat 1822..1876 CDD:293786 30/53 (57%)
ANKYR 1864..2069 CDD:440430 181/204 (89%)
ANK repeat 1879..1909 CDD:293786 27/29 (93%)
ANK repeat 1911..1943 CDD:293786 29/31 (94%)
ANK repeat 1945..1976 CDD:293786 25/30 (83%)
ANK repeat 1978..2009 CDD:293786 28/30 (93%)
ANK repeat 2011..2042 CDD:293786 26/30 (87%)
Atrophin-1 <2146..>2460 CDD:460830 129/370 (35%)

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