DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NOTCH2 and N

DIOPT Version :10

Sequence 1:NP_077719.2 Gene:NOTCH2 / 4853 HGNCID:7882 Length:2471 Species:Homo sapiens
Sequence 2:NP_476859.2 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster


Alignment Length:2735 Identity:1169/2735 - (42%)
Similarity:1543/2735 - (56%) Gaps:344/2735 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     1 MPALRPALLWALLALWL----------CCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPE 55
            :||..|.||..|....|          ..||...::.|::|       |.|||..||..||.|..
  Fly    30 LPASLPLLLLTLAFANLPNTVRGTDTALVAASCTSVGCQNG-------GTCVTQLNGKTYCACDS 87

Human    56 GFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGK--ATCRCASGFTGEDCQYSTSHPC-FVSRPCLN 117
            .::|:||:||:||...||||||||......|:  .:|:|..||....|:.:..:.| .|:  |||
  Fly    88 HYVGDYCEHRNPCNSMRCQNGGTCQVTFRNGRPGISCKCPLGFDESLCEIAVPNACDHVT--CLN 150

Human   118 GGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVA--NQFSCKCLTGFTGQKCE 180
            ||||.:.:.:.|.|.|..|:||:.|:..:.|.|.||.||:|||.:|  :.|:|.|..||||..|.
  Fly   151 GGTCQLKTLEEYTCACANGYTGERCETKNLCASSPCRNGATCTALAGSSSFTCSCPPGFTGDTCS 215

Human   181 TDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFE 245
            .|:.||. ...|::||||:|..|||||.||.|:||:.||:.|.||:||||.|||.||..| .::|
  Fly   216 YDIEECQ-SNPCKYGGTCVNTHGSYQCMCPTGYTGKDCDTKYKPCSPSPCQNGGICRSNG-LSYE 278

Human   246 CNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPN-AC 309
            |.|..||||..||:|.|||..|.|||||.|:||::.|.|||||.:||:||.:|||||..:.: .|
  Fly   279 CKCPKGFEGKNCEQNYDDCLGHLCQNGGTCIDGISDYTCRCPPNFTGRFCQDDVDECAQRDHPVC 343

Human   310 QNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCH 374
            |||.||.|.:|.|.|:|||||:|.|||.|.|||..|:|..|:||||.|.||.|.|.:||.|||||
  Fly   344 QNGATCTNTHGSYSCICVNGWAGLDCSNNTDDCKQAACFYGATCIDGVGSFYCQCTKGKTGLLCH 408

Human   375 LDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGA 439
            |||||.|||||..|:|||:|:||.|.|:|..||||.||:||:|||  ...:||||.|.||||.|:
  Fly   409 LDDACTSNPCHADAICDTSPINGSYACSCATGYKGVDCSEDIDEC--DQGSPCEHNGICVNTPGS 471

Human   440 FHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCV 504
            :.|.|.:|:.|||||.:||||.|.||||:.:|||..|.|.|:|||||.|..||::|:|||||||:
  Fly   472 YRCNCSQGFTGPRCETNINECESHPCQNEGSCLDDPGTFRCVCMPGFTGTQCEIDIDECQSNPCL 536

Human   505 NNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEE 569
            |:|.|.||:|.|:|.|..||||..|||:||||.|.||.|...|.|...||.|:|..|:||..||.
  Fly   537 NDGTCHDKINGFKCSCALGFTGARCQINIDDCQSQPCRNRGICHDSIAGYSCECPPGYTGTSCEI 601

Human   570 NIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQ 634
            ||::||.:|||.|:|.|.::|:.|:|:|||.|.||..||:||.|:||..||.|.|.|..|.|.||
  Fly   602 NINDCDSNPCHRGKCIDDVNSFKCLCDPGYTGYICQKQINECESNPCQFDGHCQDRVGSYYCQCQ 666

Human   635 PGTSGVNCEINFDDCASNPCIHG-ICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCI 698
            .||||.|||:|.::|.||||.:| .|:||||.|.|.|.||||||.|..::|||.|:||.....||
  Fly   667 AGTSGKNCEVNVNECHSNPCNNGATCIDGINSYKCQCVPGFTGQHCEKNVDECISSPCANNGVCI 731

Human   699 NGVNGFRCICPEGPHHPSCYSQVNECLSNPCIH-GNCTGGLSGYKCLCDAGWVGINCEVDKNECL 762
            :.|||::|.||.|.:...|.|.|:||.||||:: |.|..|::.:.|.|..|:.|..||:|.:||.
  Fly   732 DQVNGYKCECPRGFYDAHCLSDVDECASNPCVNEGRCEDGINEFICHCPPGYTGKRCELDIDECS 796

Human   763 SNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTG 827
            |||||:||||.:.:|.:.|.|..|:.|..|:.|||:|.:|||.|.|||.|.::||.|.|.:|:||
  Fly   797 SNPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCVTNPCGNGGTCIDKVNGYKCVCKVPFTG 861

Human   828 KNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDEC-ISKPCMNHGLCHNT 891
            ::|::.:.||:.|.|:|.|.|..|.||..::|.|..|:.|:.|..||||| :|.||.|...|.|.
  Fly   862 RDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTGRYCDEDIDECSLSSPCRNGASCLNV 926

Human   892 QGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSE 956
            .|||.|.|..|:.|.||..:.|||.:.||||||:|:||:..:||||:.||.|..|:||:|||||:
  Fly   927 PGSYRCLCTKGYEGRDCAINTDDCASFPCQNGGTCLDGIGDYSCLCVDGFDGKHCETDINECLSQ 991

Human   957 PCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSF 1021
            ||:||.|||.|||||||.|..||.|::|:.|..:||||||.|||:|:||||.::|.|..|::|:.
  Fly   992 PCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESSCLNGGSCIDGINGYNCSCLAGYSGAN 1056

Human  1022 CLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQ 1086
            |.:::|:|.|:||||..||.:....|.|.||.|:|||.|...|:.|.:|||:|..||.|.|.:..
  Fly  1057 CQYKLNKCDSNPCLNGATCHEQNNEYTCHCPSGFTGKQCSEYVDWCGQSPCENGATCSQMKHQFS 1121

Human  1087 CLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLD 1151
            |.|.:||.|..|||..:||..||.|:|:.:..|| ::|.|.:.||:|.|.|..||.||||::::|
  Fly  1122 CKCSAGWTGKLCDVQTISCQDAADRKGLSLRQLC-NNGTCKDYGNSHVCYCSQGYAGSYCQKEID 1185

Human  1152 ECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPG 1216
            ||.|.|||:|.||.|.||.|.|:|..|:||.|||..:|:|...||||||||.|.|.:|.||||||
  Fly  1186 ECQSQPCQNGGTCRDLIGAYECQCRQGFQGQNCELNIDDCAPNPCQNGGTCHDRVMNFSCSCPPG 1250

Human  1217 TRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDC 1281
            |.|::||.|.|||..|. |.|.|.|:||:||:.|.|.|||.|.|||||||||||||||:.|:|||
  Fly  1251 TMGIICEINKDDCKPGA-CHNNGSCIDRVGGFECVCQPGFVGARCEGDINECLSNPCSNAGTLDC 1314

Human  1282 IQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSS- 1345
            :||.|:|.|.||....|||||..||.|.|.||.|||.|.:..:   |..|.|..||.|..|:.| 
  Fly  1315 VQLVNNYHCNCRPGHMGRHCEHKVDFCAQSPCQNGGNCNIRQS---GHHCICNNGFYGKNCELSG 1376

Human  1346 --CGQVKCRKGEQCV--HTASGPRCFCPS---PRDCE----SGCASSPCQHGGSCHPQRQPPYYS 1399
              |....||.| .||  ....|.||.||.   ...||    ..|:.:||..|.:|......  |.
  Fly  1377 QDCDSNPCRVG-NCVVADEGFGYRCECPRGTLGEHCEIDTLDECSPNPCAQGAACEDLLGD--YE 1438

Human  1400 CQCAPPFSGSRCEL------------------YTAPPSTPPATCLSQYCADKARDGVCDEACNSH 1446
            |.|...:.|.||::                  |.|......|.|..:.|.:|..:|:||..||::
  Fly  1439 CLCPSKWKGKRCDIYDANYPGWNGGSGSGNDRYAADLEQQRAMCDKRGCTEKQGNGICDSDCNTY 1503

Human  1447 ACQWDGGDCSLTMENPWANCSSPLPCWD-YINNQCDELCNTVECLFDNFECQGNSKTCK--YDKY 1508
            ||.:||.||||.: ||||||::. .||: :.|.:|:|.||...|.:|..:|:...|:|.  :|.|
  Fly  1504 ACNFDGNDCSLGI-NPWANCTAN-ECWNKFKNGKCNEECNNAACHYDGHDCERKLKSCDSLFDAY 1566

Human  1509 CADHFKDNHCDQGCNSEECGWDGLDCA-ADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTL 1572
            |..|:.|..||.|||:.||.||||||. ..|...||||.:.:|:||..|...:....|||.:..:
  Fly  1567 CQKHYGDGFCDYGCNNAECSWDGLDCENKTQSPVLAEGAMSVVMLMNVEAFREIQAQFLRNMSHM 1631

Human  1573 LHTNLRIKRDSQGELMV--------YPYYGEKSAAMKKQRMTRRSLPGEQEQEVAGSKVFLEIDN 1629
            |.|.:|:|:|:.|..::        .|...:...|.|.:.:.      .|:....|.:::|||||
  Fly  1632 LRTTVRLKKDALGHDIIINWKDNVRVPEIEDTDFARKNKILY------TQQVHQTGIQIYLEIDN 1690

Human  1630 RQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVV----SESLTPERTQLLYLLAVAVVIIL 1690
            |:|.:...|..:..:..||..|.|.::.......|..:    .|........:.|::...:::|:
  Fly  1691 RKCTECFTHAVEAAEFLAATAAKHQLRNDFQIHSVRGIKNPGDEDNGEPPANVKYVITGIILVII 1755

Human  1691 FIILLGVIMA-KRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTG- 1753
            .:...|:::: :|||.||..|.||||.......:.:||:|.||:   ::||:.||:..:. |.| 
  Fly  1756 ALAFFGMVLSTQRKRAHGVTWFPEGFRAPAAVMSRRRRDPHGQE---MRNLNKQVAMQSQ-GVGQ 1816

Human  1754 TSEHWVDDEG--PQPKKVK---------------AEDEALLSEEDDPIDRRPWTQQHLEAADIRR 1801
            ...||.|||.  |.||:.:               |.|..::||.:: .|:|.|:|.||:..|:| 
  Fly  1817 PGAHWSDDESDMPLPKRQRSDPVSGVGLGNNGGYASDHTMVSEYEE-ADQRVWSQAHLDVVDVR- 1879

Human  1802 TPSLALTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQG 1866
                |:..|.|.|:....||:.|||.|.||||:|::|||..|..::.|:.|||:|.:|:||:.||
  Fly  1880 ----AIMTPPAHQDGGKHDVDARGPCGLTPLMIAAVRGGGLDTGEDIENNEDSTAQVISDLLAQG 1940

Human  1867 ASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIR 1931
            |.|.|..|:|||.:||||||::||||||||||||||||.|||.||.||||||||||.||||||:|
  Fly  1941 AELNATMDKTGETSLHLAARFARADAAKRLLDAGADANCQDNTGRTPLHAAVAADAMGVFQILLR 2005

Human  1932 NRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLL 1996
            ||.|:|:|||:|||||||||||||:||||.:||...||:||.|:.||:||||||||||.||..:|
  Fly  2006 NRATNLNARMHDGTTPLILAARLAIEGMVEDLITADADINAADNSGKTALHWAAAVNNTEAVNIL 2070

Human  1997 LKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRL 2061
            |.:.||||.||:|:|||||||||||||||.|.|||:||||:|||||||||||||.:|:|||||||
  Fly  2071 LMHHANRDAQDDKDETPLFLAAREGSYEACKALLDNFANREITDHMDRLPRDVASERLHHDIVRL 2135

Human  2062 LDEY--------NVTPS------PPGTVLTSALS-PVICGPNRSFLSLKHTPMGKKSRRPSAKST 2111
            |||:        ::||.      |||......:: |.:........:......||:|.:      
  Fly  2136 LDEHVPRSPQMLSMTPQAMIGSPPPGQQQPQLITQPTVISAGNGGNNGNGNASGKQSNQ------ 2194

Human  2112 MPTSLPNLAKEAK----------DAKGSRRKKSLSEKV--------------------------- 2139
              |:....||:||          ||.||.|:|:.|:|.                           
  Fly  2195 --TAKQKAAKKAKLIEGSPDNGLDATGSLRRKASSKKTSAASKKAANLNGLNPGQLTGGVSGVPG 2257

Human  2140 -----------------------QLSESSVTLSPVDSLESPHTYVSDTTS--SPMITSPGILQAS 2179
                                   :|..|.|.:....:|.||:    ||:|  |..:.:|   .|:
  Fly  2258 VPPTNSAAQAAAAAAAAVAAMSHELEGSPVGVGMGGNLPSPY----DTSSMYSNAMAAP---LAN 2315

Human  2180 PNPMLATAAPPAPVHAQHALSFSNLHEMQPLA-----------HGASTVLPSVSQLLSHHHIVSP 2233
            .||......||:     :.....|...||.|.           :..|...|...:||:...:...
  Fly  2316 GNPNTGAKQPPS-----YEDCIKNAQSMQSLQGNGLDMIKLDNYAYSMGSPFQQELLNGQGLGMN 2375

Human  2234 GSG---------------SAGSLS-----RLHPVPVPADWMNRMEVNETQYNEMFGMVLAP---A 2275
            |:|               ..|.||     ..|...:...:.|:...:..|.:    :.|:|   .
  Fly  2376 GNGQRNGVGPGVLPGGLCGMGGLSGAGNGNSHEQGLSPPYSNQSPPHSVQSS----LALSPHAYL 2436

Human  2276 EGTHPGIAPQSRPPEGKHITTPRE--------------------------------------PLP 2302
            ....|..:..|.|....||...|.                                      |..
  Fly  2437 GSPSPAKSRPSLPTSPTHIQAMRHATQQKQFGGSNLNSLLGGANGGGVVGGGGGGGGGVGQGPQN 2501

Human  2303 PIVTFQLI-PKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQQDGQVA 2366
            ..|:..:| |.||......|| |||:...|:...:....|..:..:............||..|..
  Fly  2502 SPVSLGIISPTGSDMGIMLAP-PQSSKNSAIMQTISPQQQQQQQQQQQQQHQQQQQQQQQQQQQQ 2565

Human  2367 QTIL-------------------PAYHP---FPASV-----GKYP-----TPPSQHSY------- 2392
            |..|                   .::|.   .|.|:     |..|     :|.|||:.       
  Fly  2566 QQQLGGLEFGSAGLDLNGFCGSPDSFHSGQMNPPSIQSSMSGSSPSTNMLSPSSQHNQQAFYQYL 2630

Human  2393 --ASSNAAERTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGG---AGGGQ 2452
              :|.::...||.|.  :|....|.|||||||..||||||.|.||||:...||....   :||.|
  Fly  2631 TPSSQHSGGHTPQHL--VQTLDSYPTPSPESPGHWSSSSPRSNSDWSEGVQSPAANNLYISGGHQ 2693

Human  2453 RGPGT 2457
            ...|:
  Fly  2694 ANKGS 2698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH2NP_077719.2 EGF_CA 182..218 CDD:238011 19/35 (54%)
EGF_CA 260..296 CDD:238011 22/35 (63%)
EGF_CA 298..335 CDD:238011 21/37 (57%)
EGF_CA 415..454 CDD:238011 20/38 (53%)
EGF_CA 456..492 CDD:238011 21/35 (60%)
EGF_CA 495..530 CDD:238011 21/34 (62%)
EGF_CA 532..568 CDD:238011 17/35 (49%)
EGF_CA 570..604 CDD:238011 17/33 (52%)
EGF_CA 608..643 CDD:238011 20/34 (59%)
EGF_CA 645..679 CDD:238011 21/34 (62%)
EGF_CA 682..717 CDD:238011 15/34 (44%)
EGF_CA 757..793 CDD:238011 17/35 (49%)
EGF_CA 795..831 CDD:238011 19/35 (54%)
EGF_CA 873..909 CDD:238011 19/36 (53%)
EGF_CA 911..947 CDD:238011 19/35 (54%)
EGF_CA 949..985 CDD:238011 24/35 (69%)
EGF_CA 987..1022 CDD:238011 19/34 (56%)
EGF_CA 1026..1061 CDD:238011 17/34 (50%)
EGF_CA 1117..1147 CDD:238011 14/29 (48%)
EGF_CA 1151..1185 CDD:238011 20/33 (61%)
EGF_CA 1188..1223 CDD:238011 21/34 (62%)
EGF_CA 1225..1262 CDD:238011 20/36 (56%)
EGF_CA 1264..1302 CDD:238011 25/37 (68%)
EGF_CA <1312..1343 CDD:238011 12/30 (40%)
Notch 1423..1456 CDD:459658 14/32 (44%)
Notch 1463..1497 CDD:459658 13/34 (38%)
Notch 1501..1534 CDD:459658 18/34 (53%)
NOD 1539..1594 CDD:462014 18/62 (29%)
NODP 1618..1673 CDD:462229 15/58 (26%)
JMTM_Notch2 1659..1740 CDD:411986 20/85 (24%)
ANK repeat 1827..1874 CDD:293786 23/46 (50%)
ANKYR <1851..2066 CDD:440430 161/222 (73%)
ANK repeat 1877..1907 CDD:293786 24/29 (83%)
ANK repeat 1943..1974 CDD:293786 23/30 (77%)
ANK repeat 1976..2007 CDD:293786 20/30 (67%)
ANK repeat 2009..2040 CDD:293786 25/30 (83%)
DUF5585 2068..2422 CDD:465521 100/536 (19%)
NNP_476859.2 EGF_CA 179..214 CDD:238011 17/34 (50%)
EGF_CA 217..252 CDD:238011 19/35 (54%)
EGF_CA 260..291 CDD:238011 17/31 (55%)
EGF_CA 295..329 CDD:238011 21/33 (64%)
EGF_CA 331..369 CDD:238011 21/37 (57%)
EGF_CA 449..486 CDD:238011 20/38 (53%)
EGF_CA 488..524 CDD:238011 21/35 (60%)
EGF_CA 526..562 CDD:238011 21/35 (60%)
EGF_CA 564..600 CDD:238011 17/35 (49%)
EGF_CA 602..637 CDD:238011 18/34 (53%)
EGF_CA 640..675 CDD:238011 20/34 (59%)
EGF_CA 677..713 CDD:238011 21/35 (60%)
EGF_CA 715..750 CDD:238011 15/34 (44%)
EGF_CA 753..789 CDD:238011 14/35 (40%)
EGF_CA 791..827 CDD:238011 17/35 (49%)
EGF_CA 829..865 CDD:238011 19/35 (54%)
EGF_CA 907..943 CDD:238011 18/35 (51%)
EGF_CA 946..982 CDD:238011 19/35 (54%)
EGF_CA 984..1020 CDD:238011 24/35 (69%)
EGF_CA 1027..1058 CDD:238011 17/30 (57%)
EGF_CA 1062..1095 CDD:238011 17/32 (53%)
EGF_CA 1184..1219 CDD:238011 20/34 (59%)
EGF_CA 1221..1257 CDD:238011 21/35 (60%)
EGF_CA 1259..1295 CDD:238011 20/36 (56%)
EGF_CA 1297..1335 CDD:238011 25/37 (68%)
EGF_CA 1338..1373 CDD:238011 16/37 (43%)
EGF_CA 1417..1450 CDD:238011 9/34 (26%)
NL 1476..1512 CDD:197463 13/35 (37%)
Notch 1519..1553 CDD:459658 13/34 (38%)
Notch 1565..1593 CDD:459658 16/27 (59%)
NOD 1598..1652 CDD:462014 17/53 (32%)
NODP 1679..1731 CDD:462229 14/51 (27%)
JMTM_dNotch 1719..1806 CDD:411989 22/89 (25%)
ANK repeat 1902..1948 CDD:293786 23/45 (51%)
ANKYR 1936..2139 CDD:440430 154/202 (76%)
ANK repeat 1951..1981 CDD:293786 24/29 (83%)
ANK repeat 1984..2015 CDD:293786 24/30 (80%)
ANK repeat 2017..2048 CDD:293786 23/30 (77%)
ANK repeat 2050..2081 CDD:293786 20/30 (67%)
ANK repeat 2083..2114 CDD:293786 25/30 (83%)

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