| Sequence 1: | NP_077719.2 | Gene: | NOTCH2 / 4853 | HGNCID: | 7882 | Length: | 2471 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_035058.2 | Gene: | Notch2 / 18129 | MGIID: | 97364 | Length: | 2473 | Species: | Mus musculus |
| Alignment Length: | 2474 | Identity: | 2287/2474 - (92%) |
|---|---|---|---|
| Similarity: | 2376/2474 - (96%) | Gaps: | 4/2474 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1 MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHR 65
Human 66 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYE 130
Human 131 CTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHG 195
Human 196 GTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERN 260
Human 261 IDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCV 325
Human 326 CVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALC 390
Human 391 DTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEM 455
Human 456 DINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLC 520
Human 521 PPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQ 585
Human 586 DGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCA 650
Human 651 SNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHP 715
Human 716 SCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYR 780
Human 781 CTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENA 845
Human 846 AVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEE 910
Human 911 DIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKC 975
Human 976 QAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTC 1040
Human 1041 VDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSC 1105
Human 1106 DIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGG 1170
Human 1171 YRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHC 1235
Human 1236 LNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRH 1300
Human 1301 CETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPR 1365
Human 1366 CFCPSPRDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYC 1430
Human 1431 ADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFE 1495
Human 1496 CQGNSKTCKYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQ 1560
Human 1561 DARSFLRALGTLLHTNLRIKRDSQGELMVYPYYGEKSAAMKKQRMTRRSLP--GEQEQEVAGSKV 1623
Human 1624 FLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPERTQLLYLLAVAVVI 1688
Human 1689 ILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTG 1753
Human 1754 TSEHWVDDEGPQPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDV 1818
Human 1819 LDVNVRGPDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHL 1883
Human 1884 AARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPL 1948
Human 1949 ILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETP 2013
Human 2014 LFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGTVLTS 2078
Human 2079 ALSPVICGPNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSE 2143
Human 2144 SSVTLSPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQHALSFSNLHEMQ 2208
Human 2209 PLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMVLA 2273
Human 2274 PAEGTHPGI-APQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLP 2337
Human 2338 TMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAERTP 2402
Human 2403 SHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPPHNNM 2467
Human 2468 QVYA 2471 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| NOTCH2 | NP_077719.2 | EGF_CA | 182..218 | CDD:238011 | 32/35 (91%) |
| EGF_CA | 260..296 | CDD:238011 | 34/35 (97%) | ||
| EGF_CA | 298..335 | CDD:238011 | 35/36 (97%) | ||
| EGF_CA | 415..454 | CDD:238011 | 38/38 (100%) | ||
| EGF_CA | 456..492 | CDD:238011 | 35/35 (100%) | ||
| EGF_CA | 495..530 | CDD:238011 | 33/34 (97%) | ||
| EGF_CA | 532..568 | CDD:238011 | 34/35 (97%) | ||
| EGF_CA | 570..604 | CDD:238011 | 33/33 (100%) | ||
| EGF_CA | 608..643 | CDD:238011 | 33/34 (97%) | ||
| EGF_CA | 645..679 | CDD:238011 | 30/33 (91%) | ||
| EGF_CA | 682..717 | CDD:238011 | 33/34 (97%) | ||
| EGF_CA | 757..793 | CDD:238011 | 34/35 (97%) | ||
| EGF_CA | 795..831 | CDD:238011 | 33/35 (94%) | ||
| EGF_CA | 873..909 | CDD:238011 | 31/35 (89%) | ||
| EGF_CA | 911..947 | CDD:238011 | 29/35 (83%) | ||
| EGF_CA | 949..985 | CDD:238011 | 32/35 (91%) | ||
| EGF_CA | 987..1022 | CDD:238011 | 32/34 (94%) | ||
| EGF_CA | 1026..1061 | CDD:238011 | 31/34 (91%) | ||
| EGF_CA | 1117..1147 | CDD:238011 | 27/29 (93%) | ||
| EGF_CA | 1151..1185 | CDD:238011 | 32/33 (97%) | ||
| EGF_CA | 1188..1223 | CDD:238011 | 34/34 (100%) | ||
| EGF_CA | 1225..1262 | CDD:238011 | 32/36 (89%) | ||
| EGF_CA | 1264..1302 | CDD:238011 | 32/37 (86%) | ||
| EGF_CA | <1312..1343 | CDD:238011 | 30/30 (100%) | ||
| Notch | 1423..1456 | CDD:459658 | 30/32 (94%) | ||
| Notch | 1463..1497 | CDD:459658 | 27/33 (82%) | ||
| Notch | 1501..1534 | CDD:459658 | 32/32 (100%) | ||
| NOD | 1539..1594 | CDD:462014 | 49/54 (91%) | ||
| NODP | 1618..1673 | CDD:462229 | 48/54 (89%) | ||
| JMTM_Notch2 | 1659..1740 | CDD:411986 | 70/80 (88%) | ||
| ANK repeat | 1827..1874 | CDD:293786 | 46/46 (100%) | ||
| ANKYR | <1851..2066 | CDD:440430 | 214/214 (100%) | ||
| ANK repeat | 1877..1907 | CDD:293786 | 29/29 (100%) | ||
| ANK repeat | 1943..1974 | CDD:293786 | 30/30 (100%) | ||
| ANK repeat | 1976..2007 | CDD:293786 | 30/30 (100%) | ||
| ANK repeat | 2009..2040 | CDD:293786 | 30/30 (100%) | ||
| DUF5585 | 2068..2422 | CDD:465521 | 317/354 (90%) | ||
| Notch2 | NP_035058.2 | EGF_CA | 109..143 | CDD:238011 | 31/33 (94%) |
| EGF_CA | 182..218 | CDD:238011 | 32/35 (91%) | ||
| EGF_CA | 260..296 | CDD:238011 | 34/35 (97%) | ||
| EGF_CA | 298..335 | CDD:238011 | 35/36 (97%) | ||
| EGF_CA | 415..454 | CDD:238011 | 38/38 (100%) | ||
| EGF_CA | 456..492 | CDD:238011 | 35/35 (100%) | ||
| EGF_CA | 495..530 | CDD:238011 | 33/34 (97%) | ||
| EGF_CA | 532..567 | CDD:238011 | 33/34 (97%) | ||
| EGF_CA | 570..604 | CDD:238011 | 33/33 (100%) | ||
| EGF_CA | 608..643 | CDD:238011 | 33/34 (97%) | ||
| EGF_CA | 645..679 | CDD:238011 | 30/33 (91%) | ||
| EGF_CA | 682..717 | CDD:238011 | 33/34 (97%) | ||
| EGF_CA | 757..793 | CDD:238011 | 34/35 (97%) | ||
| EGF_CA | 795..831 | CDD:238011 | 33/35 (94%) | ||
| EGF_CA | 873..909 | CDD:238011 | 31/35 (89%) | ||
| EGF_CA | 911..947 | CDD:238011 | 29/35 (83%) | ||
| EGF_CA | 949..985 | CDD:238011 | 32/35 (91%) | ||
| EGF_CA | 987..1022 | CDD:238011 | 32/34 (94%) | ||
| EGF_CA | 1025..1061 | CDD:238011 | 31/35 (89%) | ||
| EGF_CA | 1117..1147 | CDD:238011 | 27/29 (93%) | ||
| EGF_CA | 1151..1185 | CDD:238011 | 32/33 (97%) | ||
| EGF_CA | 1188..1223 | CDD:238011 | 34/34 (100%) | ||
| EGF_CA | 1225..1262 | CDD:238011 | 32/36 (89%) | ||
| EGF_CA | 1264..1302 | CDD:238011 | 32/37 (86%) | ||
| EGF_CA | <1312..1343 | CDD:238011 | 30/30 (100%) | ||
| Notch | 1423..1456 | CDD:459658 | 30/32 (94%) | ||
| Negative regulatory region (NRR). /evidence=ECO:0000250 | 1425..1679 | 223/253 (88%) | |||
| Notch | 1463..1497 | CDD:459658 | 27/33 (82%) | ||
| Notch | 1501..1534 | CDD:459658 | 32/32 (100%) | ||
| NOD | 1539..1594 | CDD:462014 | 49/54 (91%) | ||
| NODP | 1620..1675 | CDD:462229 | 48/54 (89%) | ||
| JMTM_Notch2 | 1661..1742 | CDD:411986 | 70/80 (88%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1755..1778 | 21/22 (95%) | |||
| ANK repeat | 1828..1875 | CDD:293786 | 46/46 (100%) | ||
| ANK 1 | 1828..1872 | 43/43 (100%) | |||
| ANKYR | <1852..2067 | CDD:440430 | 214/214 (100%) | ||
| ANK 2 | 1877..1906 | 28/28 (100%) | |||
| ANK repeat | 1878..1908 | CDD:293786 | 29/29 (100%) | ||
| ANK 3 | 1910..1940 | 29/29 (100%) | |||
| ANK repeat | 1944..1975 | CDD:293786 | 30/30 (100%) | ||
| ANK 4 | 1944..1973 | 28/28 (100%) | |||
| ANK repeat | 1977..2008 | CDD:293786 | 30/30 (100%) | ||
| ANK 5 | 1977..2006 | 28/28 (100%) | |||
| ANK repeat | 2010..2041 | CDD:293786 | 30/30 (100%) | ||
| ANK 6 | 2010..2039 | 28/28 (100%) | |||
| PHA03247 | <2069..2424 | CDD:223021 | 317/354 (90%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2098..2117 | 15/18 (83%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2122..2169 | 43/46 (93%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2382..2473 | 87/90 (97%) |