DRSC/TRiP Functional Genomics Resources

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Protein Alignment NOTCH2 and glp-1

DIOPT Version :10

Sequence 1:NP_077719.2 Gene:NOTCH2 / 4853 HGNCID:7882 Length:2471 Species:Homo sapiens
Sequence 2:NP_499014.1 Gene:glp-1 / 176286 WormBaseID:WBGene00001609 Length:1295 Species:Caenorhabditis elegans


Alignment Length:1857 Identity:414/1857 - (22%)
Similarity:607/1857 - (32%) Gaps:713/1857 - (38%)


- Green bases have known domain annotations that are detailed below.


Human   486 FKGVHCELEINEC-QSNPCVNNGQCVD--KVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKC 547
            |..:..:|...|| :...|..||:|.:  .:..:.|.|..||.|..|:.:.|    ..|..|.||
 Worm    11 FAPIASQLMGGECGREGACSVNGKCYNGKLIETYWCRCKKGFGGAFCERECD----LDCKRGEKC 71

Human   548 IDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECY 612
            |....|....|       :|::..|...|..    :.|.|       |..||.|..|.       
 Worm    72 IYDVYGENPTC-------ICQDCEDETPPTE----RTQKG-------CEEGYGGPDCK------- 111

Human   613 SSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQ 677
                                 .|..||||      .|.|:||.:|:|......:.|:|:.|:.|.
 Worm   112 ---------------------TPLFSGVN------PCDSDPCNNGLCYPFYGGFQCICNNGYGGS 149

Human   678 RCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNEC--LSNPCIHGNCTGGL-- 738
            .|...||.||.|.|.:|:||:|.|..:.|.||.|  ....|.:..||  :.|.|.||.|....  
 Worm   150 YCEEGIDHCAQNECAEGSTCVNSVYNYYCDCPIG--KSGRYCERTECALMGNICNHGRCIPNRDE 212

Human   739 -SGYKCLCDAGWVGINCEVDKNECL-SNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECAS 801
             ..::|:||:|:.|..|..|||||| ...|.|..||.||...:.||||.|:.|..|:..||.|..
 Worm   213 DKNFRCVCDSGYEGEFCNKDKNECLIEETCVNNSTCFNLHGDFTCTCKPGYAGKYCEEAIDMCKD 277

Human   802 NPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQ 866
            ..|.|.|.|..|                                  ..:.|     .|.|..|:.
 Worm   278 YVCQNDGYCAHD----------------------------------SNQMP-----ICYCEQGFT 303

Human   867 GQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDID--DCLAN--PCQNGGSCM 927
            ||||.|                         |||.||.|:.|:..:.  .|..:  .|.|.|.|:
 Worm   304 GQRCEI-------------------------ECPSGFGGIHCDLPLQRPHCSRSNGTCYNDGRCI 343

Human   928 DGVNTFSCLCLPGFTGDKCQ--------TDMNECLSEPCKNGGTCSDYVNS-YTCKCQAGFDGVH 983
            :|.    |:|.|.:.||:|:        .|:..|...||.|..||.|..|| |:|.|..||.|::
 Worm   344 NGF----CVCEPDYIGDRCEINRKDFKFPDIQSCKYNPCVNNATCIDLKNSGYSCHCPLGFYGLN 404

Human   984 CENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYR 1048
            ||.:: .||.::|.||||| :|:|                                     |..|
 Worm   405 CEQHL-LCTPTTCANGGTC-EGVN-------------------------------------GVIR 430

Human  1049 CSCPLGYTGKNCQTL-VNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRR 1112
            |:||.|::|..|:.. ..||||.||||.|.|                                  
 Worm   431 CNCPNGFSGDYCEIKDRQLCSRHPCKNGGVC---------------------------------- 461

Human  1113 GVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVP 1177
                             .||.||:|..||||..|||.                            
 Worm   462 -----------------KNTGYCECQYGYTGPTCEEV---------------------------- 481

Human  1178 GYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCM 1242
                                                      |:.|::.:...|           
 Worm   482 ------------------------------------------LVIEKSKETVIR----------- 493

Human  1243 DRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDV 1307
                                                                           |:
 Worm   494 ---------------------------------------------------------------DL 495

Human  1308 CPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPR 1372
            |.|..|:                                                          
 Worm   496 CEQRKCM---------------------------------------------------------- 502

Human  1373 DCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDG 1437
                                                                       |.|.:|
 Worm   503 -----------------------------------------------------------DLASNG 508

Human  1438 VCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWD-YINNQCDELCNTVECLFDNFECQGNSK 1501
            :|:..||...|.:|||||| ..:.|::.|..|..|.| :.|..|::.||..|||:|..:||....
 Worm   509 ICNPECNLEECNFDGGDCS-GGQRPFSKCQYPARCADQFANGVCNQECNNEECLYDGLDCQSELF 572

Human  1502 TC--KYDKYCADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLV----IVVLMPPEQLLQ 1560
            .|  ...|:|.:...|..|:..|:...||:||.||     .|..|..::    |.|.:.|.:...
 Worm   573 RCPAHIRKHCIERRGDGVCNLECSFIGCGFDGGDC-----NNGTEAIILSDIRIKVQIDPIEFQA 632

Human  1561 DARSFLRALGTLLHTNLRIKRDSQGELMVYPYYGE--------KSAAMKKQRMTRRSLPGEQEQE 1617
            .....|..:...|...:||:||..|.| |:.:.||        .|:.::.|.:....:...::..
 Worm   633 TGGETLMQISANLRATVRIQRDELGPL-VFRWDGEHEMERVEMNSSKLEDQFVLSHHVRRYRQAV 696

Human  1618 VAGSKVFLEIDNRQCVQDSDHC-FKNTDAAAALLASHAIQ--GTLSYPLVSVVSESLTPERTQL- 1678
            |.|..::||::.   :...:.| |....:...|:|:..::  |.:|..|....:....|:|.:: 
 Worm   697 VTGIVLYLEVEE---ICKPEFCRFSTAQSVVDLIAAGLVKSDGRMSLGLPITEAMVAVPKRNEID 758

Human  1679 -------LYLLAVAVVIILFIILLGVI-------MAKRKRKHGSLWLPEGFTLRRDASNHKRREP 1729
                   :.|.|....:....::.|||       ..|||..:.::|:|.     .:::|.|    
 Worm   759 EGWSRSQVILFACIAFLAFGTVVAGVIAKNGPERSRKRKMVNATVWMPP-----MESTNEK---- 814

Human  1730 VGQDAVGLKNLSVQVSEANLIGT------GTSEHWVD----DEGPQPKKVKAEDEA--------- 1775
                  |.:|.|...|:.:|:..      .|..|..|    ..|.|..::..:..|         
 Worm   815 ------GRRNQSNHSSQCSLLDNSAYYHPNTKRHCSDYSTGYNGEQYSQIYPQTLANGYPGDYNE 873

Human  1776 --------LLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLD------------ 1820
                    ..:..|.|.|..|   .|::||.    |. |:|.|...:.|:.:|            
 Worm   874 LNFDFQSETFAPADLPADEIP---LHVQAAG----PD-AITAPITNESVNQVDSKYRRRVLHWLA 930

Human  1821 VNVRG--PDGCTPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHL 1883
            .||||  .|..|...:..|:.|:      |.:|.|...|                     .||.|
 Worm   931 ANVRGKPEDVITTEAIRCLKAGA------DVNARDCDEN---------------------TALML 968

Human  1884 AARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNR--VTDLDARMNDGTT 1946
            |.|..|...:..||..||:....:|..|..||.||......:.:.|:.::  :.::|....:|.|
 Worm   969 AVRAHRVRLSVVLLREGANPTIFNNSERSALHEAVVNKDLRILRHLLTDKRLLKEIDELDRNGMT 1033

Human  1947 PLILAARLAVEGMV--AELI---NCQADVNAV---DDH---GKSALHWAAAVNNVEATLLLLKNG 2000
            .|:|.||...:..|  |||:   ..:.|.:..   |.:   |::|||:||..:|.|..::|::..
 Worm  1034 ALMLVARELGKHQVEMAELLLSKGAKLDYDGAARKDSNKYKGRTALHYAAMHDNEEMVIMLVRRS 1098

Human  2001 ANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEY 2065
            :|:|.||....||:.|||:||..:..:.|..:.|:..|.|.||.....||....||::...|   
 Worm  1099 SNKDKQDEDGRTPIMLAAKEGCEKTVQYLALNDASLGIVDSMDMTAAQVAEASYHHELAAFL--- 1160

Human  2066 NVTPSPPGTVLTSALSPVICGPNRSFLSLKH-----------TPMGKKSRRPSAKSTMPTSLPNL 2119
                                   |...:.:|           :..|.||.|.:.|:.        
 Worm  1161 -----------------------RQVANERHRNDIMRQQIVKSGHGAKSGRQTVKNI-------- 1194

Human  2120 AKEAKDAKGSRRKKSLSEKVQLSESSVTLSPVD---SLESPHTYVSDTTSSP--MITSPGIL--- 2176
                  .:...||...|.......:.:|..|.|   |..||| |...|||:|  |.|||..:   
 Worm  1195 ------KRAGSRKTPTSAASSRETNHLTPPPSDGSFSSPSPH-YYPTTTSTPNRMETSPEYMFNH 1252

Human  2177 -QASP-NPMLATAAPPAP----VHAQHALSFSNLHEM 2207
             .|.| |.|..|..||..    .|.....:|.|..:|
 Worm  1253 EMAPPVNAMWYTTPPPYQDPNYRHVPPNTAFQNAEQM 1289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH2NP_077719.2 EGF_CA 182..218 CDD:238011
EGF_CA 260..296 CDD:238011
EGF_CA 298..335 CDD:238011
EGF_CA 415..454 CDD:238011
EGF_CA 456..492 CDD:238011 1/5 (20%)
EGF_CA 495..530 CDD:238011 11/37 (30%)
EGF_CA 532..568 CDD:238011 8/35 (23%)
EGF_CA 570..604 CDD:238011 8/33 (24%)
EGF_CA 608..643 CDD:238011 5/34 (15%)
EGF_CA 645..679 CDD:238011 10/33 (30%)
EGF_CA 682..717 CDD:238011 15/34 (44%)
EGF_CA 757..793 CDD:238011 18/36 (50%)
EGF_CA 795..831 CDD:238011 8/35 (23%)
EGF_CA 873..909 CDD:238011 6/35 (17%)
EGF_CA 911..947 CDD:238011 11/39 (28%)
EGF_CA 949..985 CDD:238011 16/36 (44%)
EGF_CA 987..1022 CDD:238011 10/34 (29%)
EGF_CA 1026..1061 CDD:238011 7/34 (21%)
EGF_CA 1117..1147 CDD:238011 9/29 (31%)
EGF_CA 1151..1185 CDD:238011 0/33 (0%)
EGF_CA 1188..1223 CDD:238011 1/34 (3%)
EGF_CA 1225..1262 CDD:238011 1/36 (3%)
EGF_CA 1264..1302 CDD:238011 0/37 (0%)
EGF_CA <1312..1343 CDD:238011 1/30 (3%)
Notch 1423..1456 CDD:459658 11/32 (34%)
Notch 1463..1497 CDD:459658 12/34 (35%)
Notch 1501..1534 CDD:459658 10/34 (29%)
NOD 1539..1594 CDD:462014 14/58 (24%)
NODP 1618..1673 CDD:462229 11/57 (19%)
JMTM_Notch2 1659..1740 CDD:411986 17/95 (18%)
ANK repeat 1827..1874 CDD:293786 8/46 (17%)
ANKYR <1851..2066 CDD:440430 64/227 (28%)
ANK repeat 1877..1907 CDD:293786 10/29 (34%)
ANK repeat 1943..1974 CDD:293786 11/38 (29%)
ANK repeat 1976..2007 CDD:293786 11/33 (33%)
ANK repeat 2009..2040 CDD:293786 10/30 (33%)
DUF5585 2068..2422 CDD:465521 37/165 (22%)
glp-1NP_499014.1 EGF_CA 118..152 CDD:238011 12/39 (31%)
EGF_CA 155..190 CDD:238011 16/36 (44%)
EGF_CA 232..269 CDD:238011 18/36 (50%)
EGF_CA 369..406 CDD:238011 16/36 (44%)
EGF_CA 451..479 CDD:238011 17/78 (22%)
NL 489..526 CDD:197463 15/227 (7%)
Notch 533..568 CDD:459658 12/34 (35%)
Notch 573..608 CDD:459658 12/39 (31%)
NOD 611..665 CDD:462014 13/54 (24%)
ANK repeat 921..959 CDD:293786 10/43 (23%)
ANKYR <945..1172 CDD:440430 69/279 (25%)
ANK repeat 961..992 CDD:293786 11/51 (22%)
ANK repeat 994..1028 CDD:293786 7/33 (21%)
ANK repeat 1030..1061 CDD:293786 10/30 (33%)
ANK repeat 1071..1105 CDD:293786 11/33 (33%)
ANK repeat 1107..1138 CDD:293786 10/30 (33%)
ANK repeat 1140..1170 CDD:293786 9/55 (16%)
Blue background indicates that the domain is not in the aligned region.

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