DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NOTCH2 and notch2

DIOPT Version :9

Sequence 1:	NP_077719.2	Gene:	NOTCH2 / 4853	HGNCID:	7882	Length:	2471	Species:	Homo sapiens
Sequence 2:	XP_002939126.3	Gene:	notch2 / 100486344	XenbaseID:	XB-GENE-6046917	Length:	2455	Species:	Xenopus tropicalis

Alignment Length:	2477	Identity:	1705/2477 - (68%)
Similarity:	1990/2477 - (80%)	Gaps:	74/2477 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    26 LQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATC 90
            ||||...|||:|||.|:|..:|:.||||.:.|:|:|||.::||::..|.|||||...:.|.|..|
Frog    22 LQCRGASEPCLNEGKCITNDDGSAYCKCTDAFVGKYCQLQNPCQETICLNGGTCKVSSDLSKGVC 86

Human    91 RCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCAN 155
            .||.||.||:|:...::.|.:::||:||||||:|:.:.|:|.|..|:.|.:|::.|||.|.||||
Frog    87 TCAPGFGGENCKQPVANVCSLTQPCMNGGTCHLLTLELYDCICPFGWRGNDCKFIDACASQPCAN 151

Human   156 GSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDS 220
            ||||....||::|.|..|:||.|||.|||||..||.|::||||.|.||||:|||..|:|||.|:|
Frog   152 GSTCIPNENQYTCSCQAGYTGLKCEVDVNECGPPGMCKNGGTCENFPGSYRCQCHPGYTGQRCES 216

Human   221 LYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCR 285
            .::||:||||:||||||||.:|.:||||||||:|..||.||||||:|:|||||.|||||||||||
Frog   217 PFIPCSPSPCMNGGTCRQTSEFAYECNCLPGFDGKNCETNIDDCPSHKCQNGGTCVDGVNTYNCR 281

Human   286 CPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPG 350
            |||||||||||||||||.||||||||||||.|.||||.|||||||||||||:||||||.|:|..|
Frog   282 CPPQWTGQFCTEDVDECQLQPNACQNGGTCTNSNGGYNCVCVNGWSGDDCSQNIDDCATAACANG 346

Human   351 STCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTED 415
            ||||||||||.|:|||||.|||||.:|||.|||||.|:|||||||.||.|||||.||||..||||
Frog   347 STCIDRVASFICVCPEGKIGLLCHKNDACFSNPCHMGSLCDTNPLTGQAICTCPSGYKGTACTED 411

Human   416 VDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTC 480
            :|||::.||||||||||||||:|:|:|||.||:.|||||||||||.|:|||||||||||||||||
Frog   412 IDECSLVNSNPCEHAGKCVNTEGSFYCECSKGFTGPRCEMDINECLSEPCQNDATCLDKIGGFTC 476

Human   481 LCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGA 545
            |||||:||:|||:|||||.||||||||:||||||||.|:|||||||.||||||||||||||.|||
Frog   477 LCMPGYKGIHCEIEINECLSNPCVNNGECVDKVNRFVCICPPGFTGSVCQIDIDDCSSTPCQNGA 541

Human   546 KCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDE 610
            ||:|||:||:|.||||||||||||||:||:|.|||:|.||||||||||||.||||||||||||||
Frog   542 KCVDHPSGYDCICATGFTGVLCEENINNCEPPPCHYGTCQDGIDSYTCICEPGYMGAICSDQIDE 606

Human   611 CYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFT 675
            |.|:||||:|||:||||||||||.|||||..||.|.||||||||.:|.|:||||||.||||||||
Frog   607 CLSNPCLNEGRCVDLVNGYQCNCLPGTSGPRCEKNVDDCASNPCTYGNCVDGINRYDCVCSPGFT 671

Human   676 GQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSG 740
            |.:|..||||||||||..|.||:|..|.||||||||...|||:|||:||::|||||||||..::|
Frog   672 GPQCKDDIDECASNPCHNGGTCVNEQNRFRCICPEGFRQPSCFSQVDECVNNPCIHGNCTDDVNG 736

Human   741 YKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCL 805
            |||||..||.|..||||||||||||||||||||||||||||:|||||||||||::||||||||||
Frog   737 YKCLCQPGWTGKKCEVDKNECLSNPCQNGGTCDNLVNGYRCSCKKGFKGYNCQIDIDECASNPCL 801

Human   806 NQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRC 870
            |.|||.|.|:||||||.|||||.|||.:|.||||.||.|..:|:||.:|:|::||||.||.||||
Frog   802 NHGTCRDGINGYTCHCGLPYTGTNCQNILTPCSPEPCHNGGICQESEDFKSFSCLCATGWHGQRC 866

Human   871 TIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSC 935
            ||||||||:.||.|:|.|.||:|.|:|.|..||:|::||.:|||||:||||||.||:||:|||||
Frog   867 TIDIDECITNPCKNYGRCQNTKGGYICHCFEGFNGVNCENNIDDCLSNPCQNGASCVDGINTFSC 931

Human   936 LCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGG 1000
            .||.||.|||||.|::||.|.||||||:|:|||||||||||.||||:||:|||:|||::|||||.
Frog   932 NCLAGFHGDKCQKDVDECASNPCKNGGSCTDYVNSYTCKCQPGFDGIHCDNNIDECTDTSCFNGA 996

Human  1001 TCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVN 1065
            |||||||||:|.||.||||.|||.|||||.||||:|.||||||:|||.|:||:||.||||:.||:
Frog   997 TCVDGINSFTCQCPQGFTGQFCLFEINECGSHPCINGGTCVDGMGTYHCTCPVGYRGKNCEELVD 1061

Human  1066 LCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAG 1130
            |||..||||:|.|.|.|.|.:|:||:||.|.|||:|:|||::|||:|||.|:.||||:|:|||.|
Frog  1062 LCSGFPCKNRGICKQVKTEPKCICPTGWTGIYCDIPDVSCEVAASQRGVAVQDLCQHAGICINTG 1126

Human  1131 NTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQP 1195
            .:|.|||..||.|||||.:||||||||||:.|||.|..|||.|:|:|||||||||||:||||.||
Frog  1127 FSHRCQCRQGYIGSYCEGELDECASNPCQNSATCVDRHGGYECKCLPGYQGVNCEYEIDECQIQP 1191

Human  1196 CQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCA---RGPHCLNGGQCMDRIGGYSCRCLPGFA 1257
            |.|||||:||||.|:|||||||||.||||||||||   .||||.|||:|:|:||||||.||||||
Frog  1192 CHNGGTCVDLVNQFRCSCPPGTRGPLCEENIDDCAPSSEGPHCFNGGRCLDKIGGYSCECLPGFA 1256

Human  1258 GERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVA 1322
            |||||||:|||||||||::||||||||.|:|||.|:..||||||||..|:||..|||||||||||
Frog  1257 GERCEGDVNECLSNPCSAKGSLDCIQLDNNYLCKCKPGFTGRHCETIQDLCPTRPCLNGGTCAVA 1321

Human  1323 SNMPDGFICRCPPGFSGARCQ---SSCGQVKCRKGEQCVHTASGPRCFC---PSPRDCES--GCA 1379
            .|||:||.|:|||||||::||   ::||..||:.||.|:.|..||||:|   |:...|:|  |||
Frog  1322 VNMPEGFTCQCPPGFSGSKCQYSNNTCGHYKCKVGENCIKTPLGPRCYCPTGPAGNACQSKLGCA 1386

Human  1380 SSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEACN 1444
            |.||::.|.|..:.|||||:|.|.....|.:||:....      .|...:|.||||||.||:.||
Frog  1387 SQPCKNNGVCQRKDQPPYYTCNCPNGIVGLQCEILLID------GCHLHHCPDKARDGYCDQECN 1445

Human  1445 SHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNSKTCKYDKYC 1509
            :|.|.|||||||||||:|||||||.|.||:|.|.||||||||.||||||||||.....|||||||
Frog  1446 THECLWDGGDCSLTMEDPWANCSSSLKCWEYFNGQCDELCNTPECLFDNFECQEKESICKYDKYC 1510

Human  1510 ADHFKDNHCDQGCNSEECGWDGLDCAADQPENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLH 1574
            .||:.:.|||:.||::|||||||||:.|:|||||||||||||||||::||:::|:|||.||::|.
Frog  1511 EDHYANGHCDKSCNTKECGWDGLDCSTDKPENLAEGTLVIVVLMPPKELLKNSRNFLRELGSILR 1575

Human  1575 TNLRIKRDSQGELMVYPYYGEKSAAMKKQRMTRRSL-----PGEQEQEVAGSKVFLEIDNRQCVQ 1634
            |||||||:..|..||:||:.|||:|.:    :||||     ..|.|::..||||.|||||:|||.
Frog  1576 TNLRIKRNPDGSPMVFPYFREKSSAQR----SRRSLLELRVVRELEEQPIGSKVSLEIDNQQCVL 1636

Human  1635 DSDHCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPERTQLLYLLAVAVVIILFIILLGVIM 1699
            |||.|||.||:|||:||:||:||||:||||||..|...|....|:|:|.|.:.||:.|:||.|::
Frog  1637 DSDQCFKTTDSAAAMLAAHAVQGTLNYPLVSVGVEKAPPSSQTLMYILPVILAIIIVILLLVVVL 1701

Human  1700 AKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLKNLSVQVSEANLIGTGTSEHWVDDEGP 1764
            ||:|||||:||.||||.|.||.||.||||||||||||:|||||.:.:.||:.:..::||.||.||
Frog  1702 AKKKRKHGTLWFPEGFLLHRDTSNQKRREPVGQDAVGMKNLSVPIVDGNLLDSNQNDHWSDDRGP 1766

Human  1765 QPKKVKAEDEALLSEEDDPIDRRPWTQQHLEAADIRRTPSLALTPPQAEQEVDVLDVNVRGPDGC 1829
            ||||.|:|.:||||..||.:|.|.||||||.|||||.|||||||||||||::||:||||||||||
Frog  1767 QPKKSKSEGQALLSGGDDQVDSRQWTQQHLVAADIRMTPSLALTPPQAEQDMDVIDVNVRGPDGC 1831

Human  1830 TPLMLASLRGGSSDLSDEDEDAEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAK 1894
            |||||||||.||..:.::||:|||.|||:||||:||||.||||||||||.|||||||||||||||
Frog  1832 TPLMLASLRMGSPHIEEDDEEAEDPSANVITDLIYQGACLQAQTDRTGETALHLAARYSRADAAK 1896

Human  1895 RLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGM 1959
            ||||||||||:||:|||.||||||:||||||||||||||||||||||||||||||||||||||||
Frog  1897 RLLDAGADANSQDSMGRTPLHAAVSADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGM 1961

Human  1960 VAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYE 2024
            ||:|||||||||||||||||||||||||||||||::|||||||||||||||||||||||||||:|
Frog  1962 VADLINCQADVNAVDDHGKSALHWAAAVNNVEATIVLLKNGANRDMQDNKEETPLFLAAREGSFE 2026

Human  2025 AAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYNVTPSP---PGTVLTSALSPVICG 2086
            |||:|||:||||:|||||||||||:|:|||||||||||||||:..||   |||:|:::|||.:||
Frog  2027 AAKMLLDYFANREITDHMDRLPRDIAKDRMHHDIVRLLDEYNLVHSPQGQPGTMLSNSLSPAVCG 2091

Human  2087 PNRSFLSLKHTPMGKKSRRPSAKSTMPTSLPNLAKEAKDAKGSRRKKS-LSEKVQLSESSVTLSP 2150
            .|||||:|||....||:|||||||..|.||||||||.||.|..||||| ...|.|||||||||||
Frog  2092 SNRSFLNLKHAAQTKKARRPSAKSVAPRSLPNLAKEPKDTKNRRRKKSDTDSKAQLSESSVTLSP 2156

Human  2151 VDSLESPHTYVSDTTSSPMITSPGILQASPNPMLA--TAAPPAPVHAQHALSFSNLHEMQPLAHG 2213
            ||||||||     .||||.|||||.|..||..|:|  |..||     :..:|.:||   ||:...
Frog  2157 VDSLESPH-----ATSSPTITSPGALHTSPGQMIAASTLQPP-----RTTMSLTNL---QPVGCA 2208

Human  2214 ASTVLPSVSQLLSHHHIVSPGSGSAGSLSRLHPVPVPADWMNRMEVNETQYNEMFGMV------- 2271
            |:.:||||.|||||       |.....|:....:.:.:||::|||.|:||||||||:|
Frog  2209 ANNMLPSVGQLLSH-------SAQNNVLTAQRQLTMSSDWLSRMERNDTQYNEMFGIVHHDTNNH 2266

Human  2272 -LAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGP 2335
             ..|.:.   ||......|. .|:...|:.||||:|||||||..:.|.:|.   |:....|..|.
Frog  2267 SCIPQQN---GIIQADIKPT-LHMGVARDALPPIMTFQLIPKSGMNQQSGI---QTLVQQASHGQ 2324

Human  2336 -LPTMYQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAE 2399
             :..|||||:.||:...:.|.|||.|.|||::||:|.||||....:||||||||||||.|:   :
Frog  2325 NVAAMYQIPDRARITGSSVPIAMMHQHDGQLSQTMLTAYHPLQNPMGKYPTPPSQHSYTST---D 2386

Human  2400 RTPSHSGHLQGEHPYLTPSPESPDQWSSSSPHSASDWSDVTTSPTPGGAGGGQRGPGTHMSEPPH 2464
            :||:|:|||.|||||||||||||||||||||:||||||||||||||   .|.||.|.|||.|..|
Frog  2387 KTPNHNGHLPGEHPYLTPSPESPDQWSSSSPNSASDWSDVTTSPTP---NGNQRMPATHMPEQSH 2448

Human  2465 NNMQVYA 2471
            |.||:||
Frog  2449 NGMQIYA 2455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NOTCH2	NP_077719.2	EGF_CA	182..218	CDD:238011	24/35 (69%)
		EGF_CA	260..296	CDD:238011	32/35 (91%)
		EGF_CA	298..335	CDD:238011	32/36 (89%)
		EGF_CA	415..454	CDD:238011	28/38 (74%)
		EGF_CA	456..492	CDD:238011	31/35 (89%)
		EGF_CA	495..530	CDD:238011	29/34 (85%)
		EGF_CA	532..568	CDD:238011	30/35 (86%)
		EGF_CA	570..604	CDD:238011	27/33 (82%)
		EGF_CA	608..643	CDD:238011	27/34 (79%)
		EGF_CA	645..679	CDD:238011	26/33 (79%)
		EGF_CA	682..717	CDD:238011	24/34 (71%)
		EGF_CA	757..793	CDD:238011	34/35 (97%)
		EGF_CA	795..831	CDD:238011	28/35 (80%)
		EGF_CA	873..909	CDD:238011	20/35 (57%)
		EGF_CA	911..947	CDD:238011	27/35 (77%)
		EGF_CA	949..985	CDD:238011	27/35 (77%)
		EGF_CA	987..1022	CDD:238011	26/34 (76%)
		EGF_CA	1026..1061	CDD:238011	26/34 (76%)
		EGF_CA	1117..1147	CDD:238011	18/29 (62%)
		EGF_CA	1151..1185	CDD:238011	25/33 (76%)
		EGF_CA	1188..1223	CDD:238011	27/34 (79%)
		EGF_CA	1225..1262	CDD:238011	30/39 (77%)
		EGF_CA	1264..1302	CDD:238011	28/37 (76%)
		EGF_CA	<1312..1343	CDD:238011	24/30 (80%)
		Notch	1423..1456	CDD:278494	19/32 (59%)
		Notch	1463..1497	CDD:278494	27/33 (82%)
		Notch	1501..1534	CDD:278494	21/32 (66%)
		NOD	1540..1591	CDD:284282	35/50 (70%)
		NODP	1620..1673	CDD:284987	38/52 (73%)
		Ank_2	<1820..1907	CDD:289560	72/86 (84%)
		ANK repeat	1827..1874	CDD:293786	34/46 (74%)
		ANK	1872..1997	CDD:238125	116/124 (94%)
		ANK repeat	1877..1907	CDD:293786	27/29 (93%)
		Ank_2	1881..1974	CDD:289560	87/92 (95%)
		ANK	1938..2062	CDD:238125	114/123 (93%)
		ANK repeat	1943..1974	CDD:293786	29/30 (97%)
		Ank_2	1948..2040	CDD:289560	84/91 (92%)
		ANK repeat	1976..2007	CDD:293786	28/30 (93%)
		ANK repeat	2009..2040	CDD:293786	26/30 (87%)
		Chorion_3	<2292..2421	CDD:253174	69/129 (53%)
		DUF3454	2381..2444	CDD:288764	51/62 (82%)
notch2	XP_002939126.3	EGF_CA	141..176	CDD:238011	20/34 (59%)
		EGF_CA	178..215	CDD:238011	24/36 (67%)
		EGF_CA	256..292	CDD:238011	32/35 (91%)
		EGF_CA	294..331	CDD:238011	32/36 (89%)
		EGF_CA	334..369	CDD:238011	27/34 (79%)
		EGF_CA	411..450	CDD:238011	28/38 (74%)
		EGF_CA	452..488	CDD:238011	31/35 (89%)
		EGF_CA	491..526	CDD:238011	29/34 (85%)
		EGF_CA	528..564	CDD:238011	30/35 (86%)
		EGF_CA	566..600	CDD:238011	27/33 (82%)
		EGF_CA	604..639	CDD:238011	27/34 (79%)
		EGF_CA	641..676	CDD:238011	26/34 (76%)
		EGF_CA	678..713	CDD:238011	24/34 (71%)
		EGF_CA	717..751	CDD:238011	21/33 (64%)
		EGF_CA	753..789	CDD:238011	34/35 (97%)
		EGF_CA	791..827	CDD:238011	28/35 (80%)
		EGF_CA	869..905	CDD:238011	20/35 (57%)
		EGF_CA	907..943	CDD:238011	27/35 (77%)
		EGF_CA	945..980	CDD:238011	26/34 (76%)
		EGF_CA	983..1018	CDD:238011	26/34 (76%)
		EGF_CA	1022..1057	CDD:238011	26/34 (76%)
		EGF_CA	1147..1181	CDD:238011	25/33 (76%)
		EGF_CA	1184..1219	CDD:238011	27/34 (79%)
		EGF_CA	1221..1261	CDD:238011	30/39 (77%)
		EGF_CA	1263..1301	CDD:238011	28/37 (76%)
		EGF_CA	<1311..1342	CDD:238011	24/30 (80%)
		Notch	1430..1456	CDD:395019	17/25 (68%)
		Notch	1469..1497	CDD:395019	21/27 (78%)
		Notch	1506..1535	CDD:395019	19/28 (68%)
		NOD	1541..1595	CDD:399654	37/53 (70%)
		NODP	1621..1676	CDD:400155	38/54 (70%)
		JMTM_Notch_APP	1661..1742	CDD:425406	50/80 (63%)
		PHA03095	<1822..>2032	CDD:222980	187/209 (89%)
		ANK repeat	1829..1876	CDD:293786	34/46 (74%)
		ANK repeat	1879..1909	CDD:293786	27/29 (93%)
		ANK repeat	1911..1976	CDD:293786	61/64 (95%)
		ANK repeat	1978..2009	CDD:293786	28/30 (93%)
		PTZ00322	1984..>2086	CDD:140343	83/101 (82%)
		ANK repeat	2011..2042	CDD:293786	26/30 (87%)
		DUF3454	2371..2431	CDD:403221	51/62 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I9102
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7865
Inparanoid	1	1.050	3775	1.000	Inparanoid score	I133
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47077
OrthoDB	1	1.010	-	-		D2765at32523
OrthoFinder	1	1.000	-	-		FOG0007966
OrthoInspector	1	1.000	-	-		oto151811
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X659
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980