DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NOTCH1 and cdc10

DIOPT Version :9

Sequence 1:	NP_060087.3	Gene:	NOTCH1 / 4851	HGNCID:	7881	Length:	2555	Species:	Homo sapiens
Sequence 2:	NP_596132.1	Gene:	cdc10 / 2540234	PomBaseID:	SPBC336.12c	Length:	767	Species:	Schizosaccharomyces pombe

Alignment Length:	764	Identity:	143/764 - (18%)
Similarity:	253/764 - (33%)	Gaps:	252/764 - (32%)

- Green bases have known domain annotations that are detailed below.

Human  1721 VQSETVEPPPPAQLHFMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEG-FKVSEASKKKRR 1784
            :.|:.:....|.:|:.:..:...::.|   .||..::.:|        .|:. |.:|:..:
pombe    54 INSQVLRDGRPVELYAVECSGMKYMEL---SCGDNVALRR--------CPDSYFNISQILR---- 103

Human  1785 EPLGEDSVGLKPLKNASDGALMDDNQNEWGDEDLETKK----------------------FRFEE 1827
                  ..|....:||.:   :||.......|::::|.                      :...:
pombe   104 ------LAGTSSSENAKE---LDDIIESGDYENVDSKHPQIDGVWVPYDRAISIAKRYGVYEILQ 159

Human  1828 PVVLPDLD--DQTDHRQWTQQHLDAADLRMSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASC 1890
            |::..:||  .:...:|..:....:.:|..|:.....|            :|..:...|   :..
pombe   160 PLISFNLDLFPKFSKQQQIESSSISKNLNTSSFNTRSP------------LRNHNFSNP---SKS 209

Human  1891 SGGGLETGNSEEEEDAPAVISDFIY-------QGASLHNQTDRTGETALHLAARYSRSDAAKRLL 1948
            |..|:.|.|:.:...:|:  |.|:.       |.....|....|....|....:..|.|.:...|
pombe   210 SKNGVHTINNMQSSPSPS--SSFLLPLTQIDSQNVKRSNNYLSTSPPILEQRLKRHRIDVSDEDL 272

Human  1949 EASADANIQDNMGR-----TP-LHAAVS-----ADAQGVFQILIRNRATDLDARMHDGTTPLILA 2002
            ..|:..|  ||...     || |:.::|     :....:.|.::::..|..|.     .|.:.|.
pombe   273 HPSSQLN--DNEASSLFPDTPRLNHSLSFVSLVSSLPPLDQNIMQDYHTSKDI-----LTSIFLD 330

Human  2003 ARLAVEGMLEDLINSHADVNA-VDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNREETPLF 2066
            ...|....||..::...|::. :|:||.:||||||||..:.....|:..|||....|...||.|.
pombe   331 VNFADSSALEAKLSDSLDLDVPIDELGHAALHWAAAVAKMPLLQALIHKGANPLRGNLTGETALM 395

Human  2067 LAAREGSYETAKVLLDHFANR----DITDHM-------DRLPRDIAQERMHHDIVRLLDEYNLVR 2120
                      ..||:.:..|:    |:.|.:       ||..|.:    :||
pombe   396 ----------RSVLVTNHLNQNSFGDLLDLLYASLPCTDRAGRTV----VHH------------- 433

Human  2121 SPQLHGAPLGGTPTLSPPLCSPNGYLGSLKPGVQGKKVRKPSSKGLACGSKEAKDLKAR---RKK 2182
                              :|        |..|::|:            ||.....|:..   .||
pombe   434 ------------------IC--------LTAGIKGR------------GSASRYYLETLLNWAKK 460

Human  2183 SQDGKGCLLDSSGMLSPVDSLESPHGY-LSDVASPPLLPSPFQQSPSVPLNHLPGMPDTHLGIGH 2246
            ...|.                   :|| |.|..:              .|||.....||     .
pombe   461 HASGN-------------------NGYMLKDFIN--------------YLNHQDKNGDT-----A 487

Human  2247 LNVAAKPEMAALGGGGRLAFETGPPRLSHLPVASGTSTVLGSSSG-GALNFTV-----------G 2299
            ||:||:               .|...:..:.:.:|.|..:.:.:| ...||.:           .
pombe   488 LNIAAR---------------IGNKNIVEVLMQAGASAYIPNRAGLSVANFGIFVENALKQPEDS 537

Human  2300 GSTSLNGQCEWLSRLQSGMVPNQYNPLRGSVA--PGPLSTQAPSLQHGMVGPLHSSLAASALSQM 2362
            ..|.::...|.||..:...||.:... |..:|  ...:|:.....|..|..  ..|:..||.:|:
pombe   538 KQTKVSLMSENLSSKEKTAVPPRQKS-RDIIASVTDVISSLDKDFQDEMAA--KQSMIDSAYTQL 599

Human  2363 MSYQGLPSTR----LATQPHLVQTQQVQPQNLQMQQQNLQPANIQQQQS 2407
            ..     ||:    |..|.|:.:||:.....|:.:.:||. .:|::|:|
pombe   600 RE-----STKKLSDLREQLHVSETQRTLFLELRQRCKNLM-TSIEEQKS 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NOTCH1	NP_060087.3	EGF_CA	142..175	CDD:238011
		EGF_CA	178..216	CDD:238011
		EGF_CA	223..255	CDD:238011
		EGF_CA	257..293	CDD:238011
		EGF_CA	295..332	CDD:238011
		EGF_CA	335..370	CDD:238011
		EGF_CA	412..450	CDD:238011
		Interaction with DLL4. /evidence=ECO:0000250\|UniProtKB:Q07008	420..421
		Interaction with DLL4. /evidence=ECO:0000250\|UniProtKB:Q07008	448..452
		EGF_CA	452..488	CDD:238011
		EGF_CA	490..526	CDD:238011
		EGF_CA	528..564	CDD:238011
		EGF_CA	566..601	CDD:238011
		EGF_CA	603..639	CDD:238011
		EGF_CA	678..713	CDD:238011
		EGF_CA	717..750	CDD:238011
		EGF_CA	755..789	CDD:238011
		EGF_CA	791..827	CDD:238011
		EGF_CA	869..905	CDD:238011
		EGF_CA	907..943	CDD:238011
		EGF_CA	945..981	CDD:238011
		EGF_CA	988..1019	CDD:238011
		EGF_CA	1021..1057	CDD:238011
		EGF	1063..1093	CDD:278437
		EGF_CA	1146..1180	CDD:238011
		EGF_CA	1184..1219	CDD:238011
		EGF_CA	<1238..1265	CDD:238011
		EGF_CA	1267..1305	CDD:238011
		NL	1442..1479	CDD:197463
		LNR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00525	1449..1489
		Notch	1487..1522	CDD:278494
		LNR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00525	1490..1531
		Notch	1525..1561	CDD:278494
		LNR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00525	1532..1571
		NOD	1567..1618	CDD:284282
		NODP	1672..1729	CDD:284987	1/7 (14%)
		Interaction with PSEN1. /evidence=ECO:0000269\|PubMed:30598546	1728..1760		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1780..1808		3/27 (11%)
		Ank_2	<1873..1958	CDD:289560	18/91 (20%)
		ANK repeat	1880..1925	CDD:293786	10/51 (20%)
		ANK	1922..2034	CDD:238125	28/123 (23%)
		ANK repeat	1927..1958	CDD:293786	7/30 (23%)
		ANK 1. /evidence=ECO:0000255	1927..1956		6/28 (21%)
		Ank_2	1932..2025	CDD:289560	21/104 (20%)
		HIF1AN-binding. /evidence=ECO:0000250	1947..1955		2/7 (29%)
		ANK repeat	1960..1991	CDD:293786	7/41 (17%)
		ANK 2. /evidence=ECO:0000255	1960..1990		6/40 (15%)
		ANK	1989..2113	CDD:238125	36/135 (27%)
		ANK repeat	1994..2025	CDD:293786	6/31 (19%)
		ANK 3. /evidence=ECO:0000255	1994..2023		6/28 (21%)
		Ank_2	1999..2091	CDD:289560	28/96 (29%)
		HIF1AN-binding. /evidence=ECO:0000250	2014..2022		1/7 (14%)
		ANK repeat	2027..2058	CDD:293786	14/30 (47%)
		ANK 4. /evidence=ECO:0000255	2027..2056		14/28 (50%)
		ANK repeat	2060..2091	CDD:293786	7/34 (21%)
		ANK 5. /evidence=ECO:0000255	2060..2089		6/32 (19%)
		ANK 6	2095..2122		4/26 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2151..2194		8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2379..2447		8/29 (28%)
		Med25_SD1	<2429..2514	CDD:288132
		DUF3454	2479..2540	CDD:288764
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2483..2555
cdc10	NP_596132.1	KilA-N	82..150	CDD:282266	13/88 (15%)
		ANK	387..519	CDD:238125	41/249 (16%)
		ANK repeat	390..424	CDD:293786	8/43 (19%)
		ANK repeat	426..481	CDD:293786	20/142 (14%)
		Ank_2	<449..514	CDD:289560	20/117 (17%)
		ANK repeat	483..514	CDD:293786	9/50 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910