Protein Alignment CNOT3 and NOT5

DIOPT Version :10

• Sequence 1: NP_001427582.1
• Gene: CNOT3 / 4849
• HGNCID: 7879
• Length: 771
• Species: Homo sapiens
• Sequence 2: NP_015397.1
• Gene: NOT5 / 856186
• SGDID: S000006276
• Length: 560
• Species: Saccharomyces cerevisiae
• Alignment Length: 808
• Identity: 187/808 - (23%)
• Similarity: 305/808 - (37%)
• Gaps: 307/808 - (37%)

Human     4 KRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNA--ANANQKEKYEADLKKEIKKLQRLRDQIKTWV 66
            :||||.:||:.||||.||:|.|:||::|..:.  :|::.:||.|:|||:||||||:.|||||||:
Yeast     3 QRKLQQDIDKLLKKVKEGIEDFDDIYEKFQSTDPSNSSHREKLESDLKREIKKLQKHRDQIKTWL 67

Human    67 ASNEIKDKRQ-LIDNRKLIETQMERFKVVERETKTKAYSKEGLGLAQKV-DPAQKEKEEVGQWLT 129
            :..::|||:. |:.||:|||..|||||.||:..|||.:|||.|.....: ||.:.:|.:...::.
Yeast    68 SKEDVKDKQSVLMTNRRLIENGMERFKSVEKLMKTKQFSKEALTNPDIIKDPKELKKRDQVLFIH 132

Human   130 NTIDTLNMQVDQFESEVESLSVQTRKKKGDKDQKQDRIEGLKRHIEKHRYHVRMLETILRMLDND 194
            :.:|.|..|::|:|::              ::::|         .|:|.:|:..||.||:.|.|:
Yeast   133 DCLDELQKQLEQYEAQ--------------ENEEQ---------TERHEFHIANLENILKKLQNN 174

Human   195 SILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDLDLEDIPQALVATSPPSHSHMEDEIFNQSS 259
            .:..:.:.:.:||::|||:::.||||.|.:.:|:|:..|         ..||.|:      |::.
Yeast   175 EMDPEPVEEFQDDIKYYVENNDDPDFIEYDTIYEDMGCE---------IQPSSSN------NEAP 224

Human   260 STPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVPPTY 324
            ....:.||.|.|..|            ||:.||...:..|       :.|..:....:|..|
Yeast   225 KEGNNQTSLSSIRSS------------KKQERSPKKKAPQ-------RDVSISDRATTPIAP--- 267

Human   325 PSGPPPAASALSTTPGNNGVPAPAAPPSALGPKASPAPSHNSGTPAPYAQAVAPPAPSGPSTTQP 389
              |...|:.::|:||               .|.::..|.|..
Yeast   268 --GVESASQSISSTP---------------TPVSTDTPLHTV----------------------- 292

Human   390 RPPSVQPSGGGGGGSGGGGSSSSSNSSAGGGAGKQNGATSYSSVVADSPAEVALSSSGGNNASSQ 454
                                             |.:.....:|.:......|::......|.|.|
Yeast   293 ---------------------------------KDDSIKFDNSTLGTPTTHVSMKKKESENDSEQ 324

Human   455 ALGPPSGPHNPPPSTSKEPSAAAPTGAGGVAPGSGNNSGGPSLLVPLPVNPPSSPTPSFSDAKAA 519
            .|       |.||..:.|......                                   .|.:..
Yeast   325 QL-------NFPPDRTDEIRKTIQ-----------------------------------HDVETN 347

Human   520 GALLNGPPQFSTAPEIK--------APEPLSSLKSMAERAAISSGIEDPVPTLHLTERDIILSST 576
            .|..|  |.|:  .|:|        ..:||..:
Yeast   348 AAFQN--PLFN--DELKYWLDSKRYLMQPLQEM-------------------------------- 376

Human   577 SAPPASAQPPLQLSEVNIPLSLGV---CPLGPVPLTKEQLYQQAMEEAAWHHMPHPSDSERIRQY 638
             :|...:|  |:.|.:|.|.||..   |           ||.:.:.      :|||:..     :
Yeast   377 -SPKMVSQ--LESSLLNCPDSLDADSPC-----------LYTKPLS------LPHPTSI-----F 416

Human   639 LPRNPCPTPPYHHQMP----PPHSDT------------------------VEFYQRLSTETLFFI 675
            .|..|... .|.:.:|    ...:||                        ...:.:...:|||||
Yeast   417 FPNEPIRF-VYPYDVPLNLTNNENDTDNKFGKDSKAKSKKDDDIYSRTSLARIFMKFDLDTLFFI 480

Human   676 FYYLEGTKAQYLAAKAL-KKQSWRFHTKYMMWFQRHEEPKTITDEFEQIPDHLLVHSLTAFSPGQ 739
            ||:.:|:..|:|||:.| |.::|.|:.....|:.:         |.|::|            ||.
Yeast   481 FYHYQGSYEQFLAARELFKNRNWLFNKVDRCWYYK---------EIEKLP------------PGM 524

Human   740 G-----TYIYFDYEKWGQRKKEGFTFEY 762
            |     ::.||||:|....::.|..|.|
Yeast   525 GKSEEESWRYFDYKKSWLARRCGNDFVY 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNOT3	NP_001427582.1	None
NOT5	NP_015397.1	Not3	2..210	CDD:461155	89/229 (39%)
		NOT2_3_5	386..555	CDD:461199	48/211 (23%)