Protein Alignment CNOT3 and NOT3

DIOPT Version :10

• Sequence 1: NP_001427582.1
• Gene: CNOT3 / 4849
• HGNCID: 7879
• Length: 771
• Species: Homo sapiens
• Sequence 2: NP_012226.3
• Gene: NOT3 / 854773
• SGDID: S000001300
• Length: 836
• Species: Saccharomyces cerevisiae
• Alignment Length: 860
• Identity: 220/860 - (25%)
• Similarity: 358/860 - (41%)
• Gaps: 176/860 - (20%)

Human     5 RKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAA--NANQKEKYEADLKKEIKKLQRLRDQIKTWVA 67
            ||||.|:||..||::||:|.|...::: |.:.  |.:||:|.|:|||:|:|||||||:|||:|.:
Yeast     4 RKLQQEVDRVFKKINEGLEIFNSYYER-HESCTNNPSQKDKLESDLKREVKKLQRLREQIKSWQS 67

Human    68 SNEIKDKRQLIDNRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEEVGQWLTNTI 132
            |.:||||..|:|.|:.:|..||::|.||:.:|.||||...|..::.:||.::|:.::.::|:..|
Yeast    68 SPDIKDKDSLLDYRRSVEIAMEKYKAVEKASKEKAYSNISLKKSETLDPQERERRDISEYLSQMI 132

Human   133 DTLNMQVDQFESEVESLSVQTRKKKGDKDQKQDRIEGLKRHIEKHRYHVRMLETILRMLDNDSIL 197
            |.|..|.|..:.|::.|.:..:|||.......::.|..||...::|:|.:.:|..||:|.|:.:.
Yeast   133 DELERQYDSLQVEIDKLLLLNKKKKTSSTTNDEKKEQYKRFQARYRWHQQQMELALRLLANEELD 197

Human   198 VDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDLDLEDIPQALVATSPPSHSHMEDEIFNQSSSTP 262
            ...::.::||:.|:|:|:|||||.|:|.:||.|:|:         |..:.:|...:.|...::..
Yeast   198 PQDVKNVQDDINYFVESNQDPDFVEDETIYDGLNLQ---------SNEAIAHEVAQYFASQNAED 253

Human   263 TSTTSSSPIPPSPANCTTEN-SEDDKKRGRSTDSEVSQSPAKNGSKPVHSNQHPQSPAVPPTYPS 326
            .:|        |.||.:.:: |:..||..|..:.|     ||..:|....|  ....|:|...||
Yeast   254 NNT--------SDANESLQDISKLSKKEQRKLERE-----AKKAAKLAAKN--ATGAAIPVAGPS 303

Human   327 GPP----PAASALSTTPGNNGVPAPAAPPSALGPKASPAPSHNSGTPAPYAQAVAPPAPSGPSTT 387
            ..|    |.|.|...|.     .:|::.|.....|...|...:..:|...|..:.|.....||:.
Yeast   304 STPSPVIPVADASKETE-----RSPSSSPIHNATKPEEAVKTSIKSPRSSADNLLPSLQKSPSSA 363

Human   388 QPRPPS-------VQPSGGGGGGSGGGGSSSSSNS-------SAGGGAGKQNGATSYSSVVAD-- 436
            .|..|:       ..|:|..|..:....:..:..:       :|.....|....||.||.:::
Yeast   364 TPETPTNVHTHIHQTPNGITGATTLKPATLPAKPAGELKWAVAASQAVEKDRKVTSASSTISNTS 428

Human   437 ----SPAEVALSSSGGNNASSQALGPPS--------GPHNPPPSTSKEPSAAAPTGAGGVAPGSG 489
                :.|....:||..|:....||..|.        .|.|...|:| ..:|||...||..|....
Yeast   429 TKTPTTAAATTTSSNANSRIGSALNTPKLSTSSLSLQPDNTGASSS-AATAAAVLAAGAAAVHQN 492

Human   490 NN------SGGPSLLVPLPVNPPSSPTPSFSDAKAAGALLNGPPQFST-----APEIKAPEPLSS 543
            |.      |.....||.|..||.       |:.:.|..:....|:.:|     ..|.::||..:.
Yeast   493 NQAFYRNMSSSHHPLVSLATNPK-------SEHEVATTVNQNGPENTTKKVMEQKEEESPEERNK 550

Human   544 LKSMAERAAISSGIEDPVPTLHL------TERDIILSSTSAPPASAQP--PLQLS---------E 591
            |:               |||..:      ::||    |.:.|....||  |..||         |
Yeast   551 LQ---------------VPTFGVFDDDFESDRD----SETEPEEEEQPSTPKYLSLEQREAKTNE 596

Human   592 V---------NIPLSLGVCPLGPVPLTKEQLYQQAMEEAAWH-------------------HMPH 628
            :         .:.|..||...    :...:||...:|....:                   :.|.
Yeast   597 IKKEFVSDFETLLLPSGVQEF----IMSSELYNSQIESKITYKRSRDMCEISRLVEVPQGVNPPS 657

Human   629 PSDSERIRQYLPRNPCP-------TPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQY 686
            |.|:.|..|......|.       :..........::..:|.::.|...:||:.:|:......:.
Yeast   658 PLDAFRSTQQWDVMRCSLRDIIIGSERLKEDSSSIYAKILENFRTLEMFSLFYNYYFAITPLERE 722

Human   687 LAAKALKKQSWRFHTKYMMWFQRHEEPKTITDEFEQIPDHLLVHSLTAFSPGQGTYIYFDYEKWG 751
            :|.|.|.::.|:......|||.|..|.|...:..|                 .|.|..|..:.|.
Yeast   723 IAYKILNERDWKVSKDGTMWFLRQGEVKFFNEICE-----------------VGDYKIFKLDDWT 770

Human   752 QRKKEGFTFEYRYLE 766
            ...|..|..:|.:|:
Yeast   771 VIDKINFRLDYSFLQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNOT3	NP_001427582.1	None
NOT3	NP_012226.3	Not3	2..230	CDD:461155	92/226 (41%)
		PHA03247	<293..399	CDD:223021	23/110 (21%)
		NOT2_3_5	<695..782	CDD:461199	22/103 (21%)