Protein Alignment CNOT3 and Not3

DIOPT Version :10

• Sequence 1: NP_001427582.1
• Gene: CNOT3 / 4849
• HGNCID: 7879
• Length: 771
• Species: Homo sapiens
• Sequence 2: NP_610176.1
• Gene: Not3 / 35501
• FlyBaseID: FBgn0033029
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 920
• Identity: 371/920 - (40%)
• Similarity: 493/920 - (53%)
• Gaps: 227/920 - (24%)

Human     1 MADKRKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAANANQK-----EKYEADLKKEIKKLQRLRD 60
            ||..||||||||||||||:||||.|||||:|:|||.|.|||     |||||||||||||||||||
  Fly     1 MAATRKLQGEIDRCLKKVAEGVETFEDIWKKVHNATNTNQKQKHLQEKYEADLKKEIKKLQRLRD 65

Human    61 QIKTWVASNEIKDKRQLIDNRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEEVG 125
            |||:|:||.|||||..|::||:|||||||||||||||||||||||||||.|||:||||:.|::..
  Fly    66 QIKSWIASAEIKDKSSLLENRRLIETQMERFKVVERETKTKAYSKEGLGAAQKMDPAQRIKDDAR 130

Human   126 QWLTNTIDTLNMQVDQFESEVESLSVQTRKKKGDKDQKQDRIEGLKRHIEKHRYHVRMLETILRM 190
            .|||::|.:|.:|:||:|||:||| :..:||:.|:| ||:|::.|:..:::|::|:..|||:||:
  Fly   131 NWLTSSISSLQIQIDQYESEIESL-LAGKKKRLDRD-KQERMDDLRGKLDRHKFHITKLETLLRL 193

Human   191 LDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDD-LDLEDIPQALVATSPPSHSHMEDEI 254
            ||||.:..:.:.|||||||||:||||:||||||||:||| :.|:::..:..||:..::|
  Fly   194 LDNDGVEAEQVNKIKDDVEYYIDSSQEPDFEENEFIYDDIIGLDEVELSGTATTDSNNS------ 252

Human   255 FNQSSSTPTSTTSSSPIPPSPANCTTENSEDDKKRGRSTDSEVSQSPA----------KNGSKPV 309
             |::|.:|:|.||..  .||.:..|.:...:...:|.::....:.|.|          .||:...
  Fly   253 -NETSGSPSSVTSGG--SPSQSPVTVQQILNTSSQGAASSGSSAASAALFQQQLTAAQSNGNNVG 314

Human   310 HSN--QHPQSPAVPPTYPSGPPPAASALSTTPGNNGVPAPAAPPSALGPKASPAPSHNSGTPAPY 372
            :::  ....|.|...|.|:|...|.:.:........   .::..:||  |..|.| |....|.|.
  Fly   315 YASDTSAASSSATTSTDPAGGTVAVNCVGGLADKRN---KSSESNAL--KLKPQP-HQLIKPTPV 373

Human   373 AQAVAPP----------APSGPSTTQPRPPSV-----------QPSGGGGGGSGGGGSSSSSNSS 416
            ......|          ..|.||..|.:.|:.           |.|.|....:||.|:|.|::|
  Fly   374 RATAKLPLSSDTQVNKIVSSTPSKNQQQLPTAASIVATSAMQSQSSIGSCSSTGGTGASQSASS- 437

Human   417 AGGGAGKQNGATSYSSVVADSPAEVALSSSGGNNASSQALGPPSGPHNPPPSTSKEPSAAAPTGA 481
                                       .::.|||.:.|       |:.|.|..|...:|||.|..
  Fly   438 ---------------------------GNNPGNNPAVQ-------PNAPTPGQSGIAAAAASTNV 468

Human   482 GGVAPGSGNNSGGPSLLVPLPVNPPSSPTPSFSD-AKAAGALL-NGP---PQFSTAPEI------ 535
            ......|..|..|.|::.|       :||.:|:. ||...:|| |||   .|.:..|.:
  Fly   469 VSATIVSSANVQGQSVIQP-------TPTIAFAAVAKHNTSLLENGPVLQQQLAVTPTVAAIVGA 526

Human   536 ------KAPEPLS------------------------------SLKSMAERAAISSGIEDP---- 560
                  |...|||                              |||:||:.|...|.| ||
  Fly   527 GTQAQQKHVPPLSNLQTNSPHIQNGLPVSDSTNDNSCNVVDTISLKTMAQDAINRSAI-DPNSLN 590

Human   561 ---VPTLHL----TERDII--------------------------LSST--------------SA 578
               ..::.|    :::.::                          |::|              :.
  Fly   591 QQQTSSIDLRQPQSQKSLLQHFNSETNTNQQQLTSQQQQQLQNNSLAATTGSNNGTSTGSGLMNV 655

Human   579 PPASAQP-----------PLQL--SEVNIPLSLGVCPLGPVPLTKEQLYQQAMEEAAWHHMPHPS 630
            ..|:.||           |.|:  :|.:||..|||.||||.||.||...|..|.|||::|:|.|.
  Fly   656 ANATGQPISGNAKTHACQPQQMATTEAHIPTLLGVTPLGPTPLQKEHQMQFQMMEAAYYHLPQPM 720

Human   631 DSERIRQYLPRNPCPTPPYHHQMPPPHSDTVEFYQRLSTETLFFIFYYLEGTKAQYLAAKALKKQ 695
            |:|:::.|..|.|..||.::.|...|..||||||||||||||||:|||:||:|||||||||||||
  Fly   721 DTEKLQTYFHRAPVLTPSHYPQAQMPIYDTVEFYQRLSTETLFFVFYYMEGSKAQYLAAKALKKQ 785

Human   696 SWRFHTKYMMWFQRHEEPKTITDEFEQIPDHLLVHSLTAFSPGQGTYIYFDYEKWGQRKKEGFTF 760
            |||||||||||||||||||.|.|::|                 ||||||||||||.|||||||||
  Fly   786 SWRFHTKYMMWFQRHEEPKIINDDYE-----------------QGTYIYFDYEKWSQRKKEGFTF 833

Human   761 EYRYLEDRDL 770
            ||:||||::|
  Fly   834 EYKYLEDKEL 843

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNOT3	NP_001427582.1	None
Not3	NP_610176.1	Not3	3..233	CDD:461155	155/231 (67%)
		PRK07764	<334..497	CDD:236090	45/210 (21%)
		NOT2_3_5	711..836	CDD:461199	92/141 (65%)