DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip91 and SPC98

DIOPT Version :9

Sequence 1:	NP_524919.2	Gene:	Grip91 / 48481	FlyBaseID:	FBgn0001612	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_014273.1	Gene:	SPC98 / 855597	SGDID:	S000005070	Length:	846	Species:	Saccharomyces cerevisiae

Alignment Length:	741	Identity:	169/741 - (22%)
Similarity:	302/741 - (40%)	Gaps:	138/741 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 ATQSSIGLRKQSLPNYLDATKMLPESRHDIVMSAIYSFTGVQGKYLKKDVVTGRFKLDQQNIKF- 266
            :|.||:.||:.|.|.|::.   :||  .||:....|:...         ..:..|..|.:.|:.
Yeast   160 STYSSVTLRQLSNPYYVNT---IPE--EDILKYVSYTLLA---------TTSALFPFDHEQIQIP 210

  Fly   267 --LTTGQAGML-------LRLSELGYYHDRVVKFSDVSTGFNAIGSMGQALISKLKEELANFHGQ 322
              :...::|:|       |....|||   :|.||..::     |..|.:|||.::.|||.|:
Yeast   211 SKIPNFESGLLHLIFEAGLLYQSLGY---KVEKFRMLN-----ISPMKKALIIEISEELQNY--- 264

  Fly   323 VAMLHDEMQRFRQASVNGIANKGKKDSGPDAGDEMTLFKLLAWY---IKPLHRMQWLTKIADACQ 384
                        .|.||.:.:.|            |:..|.:.|   .:.:.|::...:..:..:
Yeast   265 ------------TAFVNNLVSSG------------TVVSLKSLYREIYENIIRLRIYCRFTEHLE 305

  Fly   385 VKKGGDLASTVYDFLDNGNDMVNKLVEDLLTAICGPLVRMISKWILEGGISDMHREFFVKSIKDV 449
            ...|......:..|..:|:..:.|:..:|..::.......:..|:.:|.:...:.|||:....|.
Yeast   306 ELSGDTFLIELNIFKSHGDLTIRKIATNLFNSMISLYYEYLMNWLTKGLLRATYGEFFIAENTDT 370

  Fly   450 -GVDRLWHDKFRLRLPM------LPKFVPMDMANKILMTGKSINFLREICEEQGMMKERDELMKV 507
             |.|    |.|...:|:      :|.|:|.::|.||.|.|||..||.:.|:|.....|..:...|
Yeast   371 NGTD----DDFIYHIPIEFNQERVPAFIPKELAYKIFMIGKSYIFLEKYCKEVQWTNEFSKKYHV 431

  Fly   508 MESSASQIFSYTP-DTSWHAAVETCYQQTSKHVLDIMVGPHKLLDHLHGMRRYLLLGQGDFISIL 571
            :..|.    ||.. .|::...:...|.:...|...|:.......|.:..::..||:|:.||:..|
Yeast   432 LYQSN----SYRGISTNFFEIINDQYSEIVNHTNQILNQKFHYRDVVFALKNILLMGKSDFMDAL 492

  Fly   572 IENMKNELERPGLDIYANDLTSMLDSALRCTNAQY--DDP---DILNHLDVIVQRPFNGDIGWNI 631
            ||...:.|..|...:....||.:|..|::.::.::  :.|   .::|.||..|....:|.:||::
Yeast   493 IEKANDILATPSDSLPNYKLTRVLQEAVQLSSLRHLMNSPRNSSVINGLDARVLDLGHGSVGWDV 557

  Fly   632 ISLQYIVHGPLAAMLESTMP----TYKVLFKPLWRMKHMEFVLSMKIWKEQMGNAKALRTMK--- 689
            .:|.||::.||:.:|....|    .|..:|..|||.|...:...    ||.:.:...:|:.|
Yeast   558 FTLDYILYPPLSLVLNVNRPFGRKEYLRIFNFLWRFKKNNYFYQ----KEMLKSNDIIRSFKKIR 618

  Fly   690 -------SEIGKASHRLNLFTSEIMHFIHQMQYYVLFEVIECNWVELQKKMQ----KATTLDEIL 743
                   ..|.|.| |:::..::...|..:|:.|.|..:||.|:.|:.:|:|    |:....:::
Yeast   619 GYNPLIRDIINKLS-RISILRTQFQQFNSKMESYYLNCIIEENFKEMTRKLQRTENKSQNQFDLI 682

  Fly   744 EAHEKFLQTILVGCFVSNKASV----------EHSLEVVYENIIELEKWQSSFYKDCFKELNARK 798
            ..:.   .||.:...::.||.|          :|::|... ||.|||...::|..:.........
Yeast   683 RLNN---GTIELNGILTPKAEVLTKSSSSKPQKHAIEKTL-NIDELESVHNTFLTNILSHKLFAT 743

  Fly   799 ELSKIVEKSEKKGVYGLTNKMILQRDQE-AKIFAEKMDIACRGLEVIATDYEKAVSTFLMSLNSS 862
            ..|:|.........|..:..::|....| .|::....||   |.|:.          ..|:||..
Yeast   744 NTSEISVGDYSGQPYPTSLVLLLNSVYEFVKVYCNLNDI---GYEIF----------IKMNLNDH 795

  Fly   863 DDPN--LQLFGTRLD--FNEYYKKRD 884
            :..|  |..|.|.|.  .::|...:|
Yeast   796 EASNGLLGKFNTNLKEIVSQYKNFKD 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip91	NP_524919.2	Spc97_Spc98	236..758	CDD:282045	126/565 (22%)
SPC98	NP_014273.1	GCP_N_terminal	185..467	CDD:407574	69/333 (21%)
SPC98	NP_014273.1	Spc97_Spc98	476..823	CDD:398000	87/368 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344349
Domainoid	1	1.000	73	1.000	Domainoid score	I2195
eggNOG	1	0.900	-	-		E1_KOG2000
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I1268
Isobase	1	0.950	-	0	Normalized mean entropy	S4856
OMA	1	1.010	-	-		QHG55181
OrthoFinder	1	1.000	-	-		FOG0004051
OrthoInspector	1	1.000	-	-		oto99733
orthoMCL	1	0.900	-	-		OOG6_101925
Panther	1	1.100	-	-	LDO	PTHR19302
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R54
SonicParanoid	1	1.000	-	-		X3891
TreeFam	0	0.000	Not matched by this tool.
	14	13.780