DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip91 and TUBGCP6

DIOPT Version :9

Sequence 1:	NP_524919.2	Gene:	Grip91 / 48481	FlyBaseID:	FBgn0001612	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_065194.3	Gene:	TUBGCP6 / 85378	HGNCID:	18127	Length:	1819	Species:	Homo sapiens

Alignment Length:	489	Identity:	98/489 - (20%)
Similarity:	172/489 - (35%)	Gaps:	127/489 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   430 LEGGISDMHREFFVKSIKDVGVDRLWHDKFRLRLPMLPK--FVPMDMANKILMTGKSINFLREIC 492
            |.|.....|.|.:..|.:.:....:.|    |..|:||:  ..|:|...:......::. |.|:.
Human  1419 LAGLAGQYHLERYPDSYESMSEPPIAH----LLRPVLPRAFAFPVDPQVQSAADETAVQ-LSELL 1478

  Fly   493 EEQGMMKERDELMKVMESSASQIFSYTPDTSWHAAVETCYQQTSKHVLDIMVGPHKLLDHLHGMR 557
            ....:||.                |.|...:.|.::      .:|..:|.......|..|...:|
Human  1479 TLPVLMKR----------------SITAPLAAHISL------VNKAAVDYFFVELHLEAHYEALR 1521

  Fly   558 RYLLLGQGDFISILIENMKNEL---ERPGLDIYANDLTSMLDSALRCT----------------- 602
            .:||:..|:|...|.:.:..:|   :.||..:....|.|:|..||:|:
Human  1522 HFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNSVLSKALQCSLHGDTPHASNLSLALKY 1586

  Fly   603 -------NAQYDDPDILNHLDVIVQRPFNGDIGWNIISLQYIVHGPLAAML-ESTMPTYKVLFKP 659
                   ||    ||:|:.|:                 |:|.|..||..:: |..:..|..:|..
Human  1587 LPEVFAPNA----PDVLSCLE-----------------LRYKVDWPLNIVITEGCVSKYSGVFSF 1630

  Fly   660 LWRMKHMEFVLSMKIWKEQMGNAKALRTMKSEIGKASHR-LNLFTSEIMHFIHQMQYYVLFEVIE 723
            |.::|.|.:.|     |:...:.|....:....|....| |.||..|:.||:..:|.|:..:::.
Human  1631 LLQLKLMMWAL-----KDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVIQGYIANQILH 1690

  Fly   724 CNWVELQKKMQKATTLDEILEAHEKFL-QTILVGCFVSNKASVEHSLEVVYENIIELEKWQSSFY 787
            ..|.|.:.::.....|:||..||.::| :.:..|......|.|.:.:..::..::   |::|...
Human  1691 VTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVL---KFRSQLI 1752

  Fly   788 KDCFKELNARKELSKIVEKSEKKGVYGLTNKMILQRDQEAKIFAEKMDIACRGLEVIATDYEKAV 852
            ...:               ....|..|..:.......|....|                   |..
Human  1753 SQAW---------------GPPGGPRGAEHPNFALMQQSYNTF-------------------KYY 1783

  Fly   853 STFLMS-----LNSSDDPNLQLFGTRLDFNEYYK 881
            |.||..     :|....|:|:.|..|::||.||:
Human  1784 SHFLFKVVTKLVNRGYQPHLEDFLLRINFNNYYQ 1817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip91	NP_524919.2	Spc97_Spc98	236..758	CDD:282045	77/359 (21%)
TUBGCP6	NP_065194.3	GCP_N_terminal	353..610	CDD:407574
		DUF5401	<630..834	CDD:375164
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	810..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	929..951
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1000..1023
		9 X 27 AA tandem repeats	1027..1269
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1412
		Spc97_Spc98	1513..1816	CDD:398000	75/365 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2000
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810