DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip91 and SPC98

DIOPT Version :9

Sequence 1:	NP_524919.2	Gene:	Grip91 / 48481	FlyBaseID:	FBgn0001612	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_196286.1	Gene:	SPC98 / 830557	AraportID:	AT5G06680	Length:	838	Species:	Arabidopsis thaliana

Alignment Length:	904	Identity:	243/904 - (26%)
Similarity:	432/904 - (47%)	Gaps:	120/904 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SNIINEMIICI--KGKQMPEVHEKAMDHLSKMIAA----NSR----VIRDSNMLTERECVQKIMK 73
            ::::.|:::.:  :..|.|.:...:...|..:..|    :||    |:.|:..:.|     .:.:
plant    10 ADLVQELVLRLVSQNPQTPNLDPNSPAFLKTLRYAFRILSSRLTPSVLPDATAIAE-----SLKR 69

  Fly    74 LLSARNKKEEGKTVSDHFNELYRKLTLTKCDPHMRHS--LMTHLLTMTDNSDAEKAVASEDPRTQ 136
            .|:.:.|..:...    |.:||.|.. :|..|...::  .:.:||          .:.|:|.:
plant    70 RLATQGKSSDALA----FADLYTKFA-SKTGPGSVNNKWALVYLL----------KIVSDDRK-- 117

  Fly   137 CDNLTQILVSRLNSISSSIASLNEMGVVN-GNGVGAAAVTGAAAVTGAAAVTGAAAVTGAAASHS 200
                     |.:|.:.||:. |..:|:.: ||||                     ...|.|....
plant   118 ---------SAINGLDSSVL-LPNLGIGDTGNGV---------------------LSRGEAKKKD 151

  Fly   201 YD-----ATQSSIGLRKQSLPNYLDATKMLPESRHDI-VMSAIYSFTGVQGKYLKKDVVTGRFKL 259
            :.     .::....||..:...|....|...|...:: |...:|:..|:.|||:|.:.....:.:
plant   152 WSNGVLLVSKDPENLRDIAFREYAILVKEENEVTEEVLVRDVLYASQGIDGKYVKFNSEIDGYAV 216

  Fly   260 DQQNIKFLTTGQAGMLLRLSELGYYHDRVVKF-SDVSTGFNA--IGSMGQALISKLKEELANFHG 321
             |:::| :......|:..|||||:...:|..| ::....|.|  :|::|||..:.|::||::::.
plant   217 -QESVK-VPRATRIMVRMLSELGWLFRKVKTFITESMDRFPAEDVGTVGQAFCAALQDELSDYYK 279

  Fly   322 QVAMLHDEMQRFRQASVNGIANKGKKDSGPDAGDEMTLFKLLAWYIKPLHRMQWLTKIADACQVK 386
            .:|:|..:       ::|.|....:..|   :.:.::|.:|..|:.:|:.:|:.:..:.|.|:|.
plant   280 LLAVLEAQ-------AMNPIPLVSESAS---SNNYLSLRRLSVWFAEPMVKMRLMAVLVDKCKVL 334

  Fly   387 KGGDLASTVYDFLDNGNDMVNKLVEDLLTAICGPLVRMISKWILEGGISDMHREFFVKSIKDVGV 451
            :||.:|..::....:|:.:|:..:..||..:|.||..|:..|:|||.:.|...||||.. :.|.|
plant   335 RGGAMAGAIHLHAQHGDPLVHDFMMSLLRCVCSPLFEMVRSWVLEGELEDTFGEFFVVG-QPVKV 398

  Fly   452 DRLWHDKFRLRLPMLPKFVPMDMANKILMTGKSINFLREICEEQGMMKERDELMKVMESSASQ-- 514
            |.||.:.::|...|||.|:...:|.:||.|||||||||..|::.|......|......::..:
plant   399 DLLWREGYKLHPAMLPSFISPSLAQRILRTGKSINFLRVCCDDHGWADAASEAAAASGTTTRRGG 463

  Fly   515 IFSYTPDTSWHAAVETCYQQTSKHVLDIMVGPHKLLDHLHGMRRYLLLGQGDFISILIENMKNEL 579
            :.....|...|...|.. ::..||:||::...:|..:|...::||||||||||:..|::.:..:|
plant   464 LGYGETDALEHLVTEAA-KRIDKHLLDVLYKRYKFKEHCLAIKRYLLLGQGDFVQYLMDIVGPKL 527

  Fly   580 ERPGLDIYANDLTSMLDSALRCTNAQYDDPDILNHLDVIVQRPFNGDIGWNIISLQYIVHGPL-A 643
            ..|..:|.:.:|...|::|:|.:||||||.|:|:.|.|.:....:||.||::.||:|....|| .
plant   528 SEPANNISSFELAGFLEAAIRASNAQYDDRDMLDRLRVKMMPHGSGDRGWDVFSLEYEARVPLDT 592

  Fly   644 AMLESTMPTYKVLFKPLWRMKHMEFVLSMKIWKEQMGN-------AKALRTMKSEIGKASHRLNL 701
            ...||.:..|..:|..||::|.:|..| :.|||....|       .|...::|.::..|..|..:
plant   593 VFTESVLSKYLRVFNFLWKLKRVEHAL-IGIWKTMKPNCITSNSFVKLQSSVKLQLLSALRRCQV 656

  Fly   702 FTSEIMHFIHQMQYYVLFEVIECNWVELQKKMQKATTLDEILEAHEKFLQTILVGCFVSNKA-SV 765
            ..:|:.||:...|||::|||:|.:|....|:|:.|..||::|.||||:|..|:....:..:: ::
plant   657 LWNEMNHFVTNFQYYIMFEVLEVSWSNFSKEMEAAKDLDDLLAAHEKYLNAIVGKSLLGEQSQTI 721

  Fly   766 EHSLEVVYENIIELEKWQSSFYKDCFKELNAR-KELSKIVEKSEKKGVY------GLTNKMILQR 823
            ..||.|::|.|:.........|:. ..||..| ||..:...||::.|.:      |||
plant   722 RESLFVLFELILRFRSHADRLYEG-IHELQIRSKESGREKNKSQEPGSWISEGRKGLT------- 778

  Fly   824 DQEAKIFAEKMDIACRGLEVIATDYEKAVSTFLMSLNSSDDPNLQLFGTRLDFNEYYKK 882
             |.|..|.:.|.   :.::.||.:|..::..||..|......:|:....||||.|:|.:
plant   779 -QRAGEFLQSMS---QDMDSIAKEYTSSLDGFLSLLPLQQSVDLKFLFFRLDFTEFYSR 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip91	NP_524919.2	Spc97_Spc98	236..758	CDD:282045	169/534 (32%)
SPC98	NP_196286.1	GCP_N_terminal	190..493	CDD:407574	91/316 (29%)
SPC98	NP_196286.1	Spc97_Spc98	499..831	CDD:398000	111/344 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	172	1.000	Domainoid score	I1145
eggNOG	1	0.900	-	-		E1_KOG2000
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4609
Inparanoid	1	1.050	311	1.000	Inparanoid score	I739
OMA	1	1.010	-	-		QHG55181
OrthoDB	1	1.010	-	-		D480444at2759
OrthoFinder	1	1.000	-	-		FOG0004051
OrthoInspector	1	1.000	-	-		oto3086
orthoMCL	1	0.900	-	-		OOG6_101925
Panther	1	1.100	-	-	LDO	PTHR19302
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3891
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840