DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip91 and Tubgcp2

DIOPT Version :9

Sequence 1:	NP_524919.2	Gene:	Grip91 / 48481	FlyBaseID:	FBgn0001612	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001272936.1	Gene:	Tubgcp2 / 74237	MGIID:	1921487	Length:	905	Species:	Mus musculus

Alignment Length:	932	Identity:	206/932 - (22%)
Similarity:	359/932 - (38%)	Gaps:	248/932 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 THLLTMTDNSDAEKAVASEDPRTQCD--------------NLTQI--LVSRLNSISSSIASLNEM 161
            |..:|.|.::.:.|...:|..||..|              ||..:  |:|:|.....::..|.:
Mouse    37 TPYVTTTVSAHSAKVKIAEFSRTPEDFLKKYDELKSKNTRNLDPLVYLLSKLTEDKETLQFLQQ- 100

  Fly   162 GVVNGNGVGAAAVTGAAAVTGAAAVTGAAA-----------------VTGAAASHSYDATQSSIG 209
               |.......|.:.|.:.|.:.::..||:                 .||:....|.:.|:..:.
Mouse   101 ---NAKERAELAASAATSNTTSFSIPVAASKMSTQELEELRKQLGSVSTGSTLQQSLELTRKMLR 162

  Fly   210 LRK------QSLPNY-------------------LDATKMLP-------ESRHDIVMSAIYSFTG 242
            .::      |.||.:                   |.:..:||       .....:|...:|...|
Mouse   163 DKQNKKNSGQPLPVFPAWVYERPTLAGDFLIGSGLSSDTVLPIGTLPLASQESAVVEDLLYVLVG 227

  Fly   243 VQGKYLKKDVVTGRFKLDQQNIKFLTTGQAGMLL-----RLSELGYYHDRVVKFSDVSTGFNAIG 302
            |.|:|:....:.||     ||..||......:.:     |:..:...:..|.:|.:..:.|. .|
Mouse   228 VDGRYITAQPLAGR-----QNRTFLVDPNLDLSIRELVNRILPVAASYSTVTRFIEEKSSFE-YG 286

  Fly   303 SMGQALISKLK---EELANFHGQVAMLHDEMQRFRQASVNGIANKGKKDSGPDAGDEMTLFKLLA 364
            .:..||.:.::   :|......|:..||      ||    |:               ::|.||
Mouse   287 QVNHALAAAMRTLVKEYLILVTQLEQLH------RQ----GL---------------LSLQKL-- 324

  Fly   365 W-YIKPLHRMQWLTKIAD-ACQVKK----GGDLASTVYD--FLDNGNDMVNKLVEDLLTAICGPL 421
            | ||:|  .|:.:..:|. |..|.|    ||...|.::|  |...|:....:|...|..|...|.
Mouse   325 WFYIQP--AMRTIDILASLATSVDKGECVGGSTLSLLHDRSFNYTGDSQAQELCLYLTKAASAPY 387

  Fly   422 VRMISKWILEGGISDMHREFFV-------KSIKDVGVDRLWHDKFRLRLPMLPKFVPMDMANKIL 479
            ..::.|||..|.|.|.:.||.|       :.|::...|:.|..::.:....:|.|: ..:|.|||
Mouse   388 FEILEKWIYRGIIHDPYSEFMVEEHELRKEKIQEDYNDKYWDQRYTVLPQQIPSFL-QKVAGKIL 451

  Fly   480 MTGKSINFLREICEEQGMMKERDELMKVMESSASQIFSYTPDTSWHAAVETCYQQTSKHVLDIMV 544
            .|||.:|.:||...:            |....|.:|.....:.::...:|..:...||.:||.::
Mouse   452 STGKYLNVVRECGHD------------VTCPVAKEIIYTLKERAYVEQIEKAFNYASKVLLDFLM 504

  Fly   545 GPHKLLDHLHGMRRYLLLGQGDFISILIENMKNELERPGLDIYANDLTSMLDSALRCTNAQYDDP 609
            ...:|:.||..::||.|:.||||....::..:.||.:|..||....|.::|:.|||.:.|..|
Mouse   505 EEKELVAHLRSIKRYFLMDQGDFFVHFMDLTEEELRKPVEDIILTRLEALLELALRMSTANTD-- 567

  Fly   610 DILNHLDVIVQRPFNGDI--------------------------------------GWNIISLQY 636
                        ||..|:                                      |....|..|
Mouse   568 ------------PFKDDLKIELMPHDLITQLLRVLAIETKQEKAMTHADPTELTLSGLEAFSFDY 620

  Fly   637 IVHGPLAAML-ESTMPTYKVLFKPLWRMKHMEFVLSMKIW-KEQMGNAKALRTMKSEIGKASHRL 699
            :|..||:.:: ...:..|::||:.::..||:|..| ..:| ..:.....||.:.|...|..:.|
Mouse   621 MVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQL-CSVWISNKTAKQHALHSAKWFAGAFTLR- 683

  Fly   700 NLFTSEIMHFIHQMQYYVLFEVIECNWVELQKKMQKATTLDEILEAHEKFLQTILVGCFVSNKAS 764
                ..:::|:..:|||::|||:|..|..|:|.::.|:.:|::|..|..||...|..|.::|...
Mouse   684 ----QRMLNFVQNIQYYMMFEVMEPTWHILEKNLKSASNIDDVLGHHTSFLDNCLKDCMLTNPEL 744

  Fly   765 VE-----HSLEVVYENIIELEKWQSSFYKDCFKELNARKELSKI-------------VEKSEKKG 811
            ::     .|:.|::.|.  ::|:..|...|        .||.::             .|:.|.:.
Mouse   745 LKVFSKLMSVCVMFTNC--MQKFTQSMKLD--------SELGRLTLDQGSVQGPPTETERIEDRP 799

  Fly   812 VYGLTNKMILQRDQEAKIFAEKMDI--ACRGLEVIATDYEKAVSTFLMSL-------NSSD-DPN 866
            ...||.|.:          :|.:|.  ...|.|....:::|..|..|:.|       ::|| :..
Mouse   800 RKELTRKHL----------SEHVDAPQLASGFEATINNFDKNFSAHLLDLLARLSVYSTSDCEHG 854

  Fly   867 LQLFGTRLDFNEYYKKRDTNLS 888
            :....:|||||.:|.:|...||
Mouse   855 MASVISRLDFNGFYAERLERLS 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip91	NP_524919.2	Spc97_Spc98	236..758	CDD:282045	141/584 (24%)
Tubgcp2	NP_001272936.1	Spc97_Spc98	220..738	CDD:282045	141/585 (24%)
Tubgcp2	NP_001272936.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..905		206/932 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910