DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip91 and tubgcp4

DIOPT Version :9

Sequence 1:	NP_524919.2	Gene:	Grip91 / 48481	FlyBaseID:	FBgn0001612	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001128602.1	Gene:	tubgcp4 / 557155	ZFINID:	ZDB-GENE-081022-124	Length:	668	Species:	Danio rerio

Alignment Length:	720	Identity:	144/720 - (20%)
Similarity:	271/720 - (37%)	Gaps:	193/720 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 QNIKFLTTGQAGMLLRLSELGYYHDRVVKFSDVSTGF-------------------------NAI 301
            |::.||...:..:|.||.::|..:.|..:|.:..||.                         ..:
Zfish    29 QDLPFLHPSETSVLNRLCKMGTDYVRFTEFIEQHTGHVHQQEHYSSQPSQSGLHGIYLRAFCTGL 93

  Fly   302 GSM----GQALISKLKEELANFHGQVAMLHDEMQRFRQASVNGIANKGKKDSGPDAGDEMTLFKL 362
            .||    .|||:...||.|.:.|..::.::..:::|:                       .||..
Zfish    94 HSMLQPYRQALLDLEKEFLGDPHLSISHVNYMLEQFQ-----------------------LLFPS 135

  Fly   363 LAWYIKPLHRMQWLTKIADACQVKKGGDLASTVYDFLDNGNDMVNKLVEDLLTAICGPLVRMISK 427
            :...::.:...:     ...||:      ..|||.....|...|...:|.:|....|.:.:.::.
Zfish   136 VMVVVETIKSQK-----IHGCQI------LETVYKHSCGGLPPVRMALEKILAVCHGVMYKQLAA 189

  Fly   428 WILEGGISDMHREFFVK--------------SIKDVGVD-------------RLWHD-------- 457
            |:|.|.:.|...|||||              ..:|:|:.             ||..:
Zfish   190 WMLHGLLLDQSEEFFVKQGPSAGGATAAQEEDEEDLGIGGLSGKQLRELQDLRLIEEENMLAPSL 254

  Fly   458 -KFRLRLPMLPKFVPMDMANKILMTGKSI----NFLREICEEQGMMKERDELM--KVMESSASQI 515
             :|.||:.|||.::|:.:|.|||..|:|:    |..:.......::|.::::.  ::.......:
Zfish   255 QQFSLRVEMLPSYIPVRVAEKILFVGESVQMFENHNQSPSRAGSILKHQEDMFAAELHRLKQQPL 319

  Fly   516 FSYTPDTSWHAAVETCYQQTSKHVLDIMVGPHKLLDHLHGMRRYLLLGQGDFISILIENMKNELE 580
            ||.   ..:...|:......::|:..:||....||..|..::.:.|||:|:...:.|:..::.|:
Zfish   320 FSL---VDFENLVDGIRSTVAEHLWTLMVEESDLLGQLKIIKDFFLLGRGELYQVFIDLAQHMLK 381

  Fly   581 RPGLDIYANDLTSMLDSALRCTNAQYDDPDILNHLDVIVQRPFNG-------------------- 625
            .|...:..:|:......|..  ....||.::|..|.:.:.  ::|
Zfish   382 TPPSAVTEHDVNVAFQQAAH--KVLLDDDNLLPLLHLTID--YHGKESKEGSGNREGTTPPQESS 442

  Fly   626 -----DIGWNIISLQYIVHGPL-----AAMLESTMPTYKVLFKPLWRMKHMEFVLSMKIWKEQMG 680
                 ..||..:.|.|.|..||     .|:||.    |.|:|:.|..::.::..| ...|..||
Zfish   443 PREAPPTGWAALGLAYKVQWPLHILFTPAVLEK----YNVVFRYLLSVRRVQSEL-QHCWALQM- 501

  Fly   681 NAKALRTMKSEIGKASHRLNLFTSEIMHFIHQMQYYVLFEVIECNWVELQKKMQKATTLDEILEA 745
            ..|.|::.:::..|...|     :.:...:..:|||:..:|:|..:.:|.:::......:.|..|
Zfish   502 QRKHLKSNQTDAVKWRLR-----NHMAFLVDNLQYYLQVDVLESQFSQLLQQINSTRDFESIRLA 561

  Fly   746 HEKFLQTILVGCFVSNKASVEHSLEVVYENIIELEKWQSSFYKDCFKELNARKELSKIVEKSEKK 810
            |:.||..:|...|:..| .|.|.|    ..|::|          |.   |....:|:.:...:::
Zfish   562 HDHFLSNLLAQSFILLK-PVFHCL----NEILDL----------CH---NFCSLVSQNLGSLDER 608

  Fly   811 GVYGLTNKMILQRDQEAKIFAEKMDIACRGLEVIATDYEKAVSTFLMSLNSSDDPNLQLFGTRLD 875
            |                   ..::||..:|....:....|.:|:......:||...|.|   |||
Zfish   609 G-------------------TAQLDILVKGFSRQSFLLFKILSSVRNHQINSDLAQLLL---RLD 651

  Fly   876 FNEYY 880
            :|:||
Zfish   652 YNKYY 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip91	NP_524919.2	Spc97_Spc98	236..758	CDD:282045	118/596 (20%)
tubgcp4	NP_001128602.1	Spc97_Spc98	4..574	CDD:282045	118/596 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910