DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip91 and Grip128

DIOPT Version :9

Sequence 1:	NP_524919.2	Gene:	Grip91 / 48481	FlyBaseID:	FBgn0001612	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_573030.2	Gene:	Grip128 / 32478	FlyBaseID:	FBgn0026433	Length:	1092	Species:	Drosophila melanogaster

Alignment Length:	852	Identity:	154/852 - (18%)
Similarity:	264/852 - (30%)	Gaps:	313/852 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QMPEVHEKAMDHLSKMIAANSRVIRDSNMLTERECVQ----KIMK--LLSARNKKEEGKTVSDHF 91
            :|..|:|:||     |....:..:..:.|..|:..::    :|||  :||..|.|
  Fly   231 EMARVYEQAM-----MAVVPTGSVNKTYMPPEQSVIRSYDFRIMKPTVLSLNNLK---------- 280

  Fly    92 NELYRKLTLTKCDPHMRHSLMTHLLTMTDNSDAEKAVASEDPR--TQ------CDNLTQILVS-- 146
                        ..|:|.|.:..|            ...:.||  ||      .|.|.:.:.|
  Fly   281 ------------GSHLRRSKLLQL------------PPPQPPRPFTQYWQSGNTDTLFRKIHSHW 321

  Fly   147 -----RLNSISSSIASLNEMGV-----VNGNGVGAAAVTGAAAVTGAAAVTGAAAVTGAAAS--- 198
                 .||::.||...|:...|     :|.|..|..|:.....:|....:.....:....||
  Fly   322 WCQDVHLNALPSSAKPLDNFAVSYVQFLNHNARGLLALPVPKTITEPCLLREILFMFVRPASCCF 386

  Fly   199 HSYDATQSSIGLR---------KQSLPNYL-----DATKMLPESRHDIVMSAIYSFTGVQGKYLK 249
            ..:|.....|.:|         ..::.|:|     .|.:.:.|.|| |:.:....|.||:..|
  Fly   387 FEFDKATRRITVRDNVSICTVTASTMQNFLLFDVVPALEDMMELRH-IIDTHTLHFHGVKTTY-- 448

  Fly   250 KDVVTGRFKLDQQNIKFLTTGQAGMLLRLSELGY-YHDRVVKFSDVSTGFNAIGSMGQALISKLK 313
                         .::|...|...::..:.:|.. |.|||.|                   ...|
  Fly   449 -------------TVEFFAYGLRDLVQPICQLLIAYEDRVNK-------------------DPAK 481

  Fly   314 EELANFHGQVAMLHDEMQRFRQASVNGIANKGKKDSGPDAGDEMTLFKLLAWYIKPLHRMQWLTK 378
            ..|..|..:......:::..|:.:.:.|.:||                       |.|
  Fly   482 NTLIRFTIEFREHFSQLRLLRELAEDVILDKG-----------------------PAH------- 516

  Fly   379 IADACQVKKGGDLASTVYDFLDNGNDMVNKLVEDLLTAICGPLVR----MISKWILEGGISDMHR 439
                   .:...|.|.:|.     :.::....:.|.||:....::    :|..|.....:.|..|
  Fly   517 -------IRSAYLLSRLYK-----HTLLQVPHQKLATALLFISLKRYCIIIDGWWRRAALEDHLR 569

  Fly   440 EFFVKSIKDVGVDRLWHDKFRLRLPMLPKFVPMDMANKILMTGKSINFLREICEEQGMMKERDEL 504
            ||.|:...:...:...|.:.|                                 ..||   .|:|
  Fly   570 EFIVEFCYEEDANTRSHVRKR---------------------------------NMGM---EDDL 598

  Fly   505 MKVMESSASQIFSYTPDTSWHAAVETC--YQQTSKHVLDIMVGPHKLLDHLHGMRRYLLLGQGDF 567
            :.|      :||:         .:::|  ||...:|.|:            .|..:.||......
  Fly   599 LLV------EIFN---------KLQSCPLYQLLLEHALE------------SGETQDLLCSVNTL 636

  Fly   568 ISILIENMKNELERPGLDIYANDLTSMLDSALR----CTNAQYDD---PD-------------IL 612
            ..:|..|  ||::.|.|.   ::|.:...:.|:    ..|..|:|   ||             |.
  Fly   637 SEMLTSN--NEIQLPSLH---DELFTQFFAQLKVYCGADNTDYEDEPEPDKDYEDLTVCNRQGIR 696

  Fly   613 NH-LDVIVQRPF--------------NGDIGWNIISLQYIVHGPLAAMLESTMPTYKVLFKPLWR 662
            || |..|..:|.              |..:..||:..   :.......|:|.:|
  Fly   697 NHELFAIFTQPLVEQRLERQRERLKSNPVLMANILKR---LERSTCLQLKSELP----------- 747

  Fly   663 MKHMEFVLSMKIWKEQMGNAKALRTMKSEIGKASHRLNLFTSEIMHFI-HQM---QYYVLFEVIE 723
             :.:..:|..:.|   :.|..|:|....|...|         |.|.|: |.|   :||:......
  Fly   748 -EALREILRRRQW---LANEYAIRAYCKETQVA---------EKMRFLRHTMLLEKYYLFVPYYN 799

  Fly   724 CNWVELQKKMQKA------TTLDEILEAH----EKFLQTILVGCFVSNKASVEHSLEVV---YEN 775
            ..:|.::|....|      :.|..:|..|    ..:|...|:....||...|..:||.:   :|.
  Fly   800 ALFVRMEKNNSWALGSVLTSKLCAVLLPHYPQLAHYLHVKLISQINSNSIKVYEALEAIELDFER 864

  Fly   776 IIELEKW 782
            .:.:.:|
  Fly   865 PMAMHQW 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip91	NP_524919.2	Spc97_Spc98	236..758	CDD:282045	98/577 (17%)
Grip128	NP_573030.2	Spc97_Spc98	373..>580	CDD:282045	46/283 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455394
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19302
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030