DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip91 and Tubgcp3

DIOPT Version :9

Sequence 1:	NP_524919.2	Gene:	Grip91 / 48481	FlyBaseID:	FBgn0001612	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001100793.2	Gene:	Tubgcp3 / 306599	RGDID:	1305726	Length:	902	Species:	Rattus norvegicus

Alignment Length:	958	Identity:	301/958 - (31%)
Similarity:	486/958 - (50%)	Gaps:	125/958 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VATNSTDISNIINEMIIC-IKGKQMPEVHEKAMDHLSKMIAAN--SRVIRDSNMLTERECVQKIM 72
            :||......|::.:.:.| |.|:...:|.:: .....::|.:|  ..|.||..::.|     ||.
  Rat     1 MATPDQKSPNVLLQNLCCRILGRSEADVAQQ-FQFAVRVIGSNFAPTVERDEFLVAE-----KIK 59

  Fly    73 KLLSARNKKEEGKTVSDHFNELYRKLTLTKCDPHM------RHSLMTHLLTMTDNSDAEKAVASE 131
            |.| .|.::|....:   |:||:|||       |.      :.|::..||.:           ||
  Rat    60 KEL-IRQRREADAAL---FSELHRKL-------HSQGVLKNKWSILYLLLNL-----------SE 102

  Fly   132 DPRTQCDNLT-------QILVSRLNS------------ISSSIASLNEMGVVNGNGVGAAAVTGA 177
            |||.|...:|       |.|....:|            ::....|....|.:..:|:.:..:.|
  Rat   103 DPRKQASKVTSYASLFAQALPRDAHSTPYYCARPQTLPLNYQDRSTQSSGSLGSSGISSIGMCG- 166

  Fly   178 AAVTGAAAVTGAAAVTGAAASHSYDATQSSIGLRKQ---------------------SLPNYLDA 221
                    ::|...|.......|:.|.....|||:|                     :.||.|
  Rat   167 --------LSGPTPVQPFLPGQSHQAPGVGDGLRQQLGPRLAWTLTGNQPSQTPTSKAFPNAL-- 221

  Fly   222 TKMLPESRHD-------------IVMSAIYSFTGVQGKYLKKDVVTGRFKLDQQNIKFLTTGQAG 273
            ::.|..||.:             :|...:|.|.|:.||.:|.......:|::.:  ..|:.....
  Rat   222 SRNLTRSRREGDPGGTSEVTEAALVRDILYVFQGIDGKNIKMSSTENCYKVEAK--ANLSKSLRD 284

  Fly   274 MLLRLSELGYYHDRVVKFSDVSTGFNAIGSMGQALISKLKEELANFHGQVAMLHDEMQRFRQASV 338
            ..:||:|||:.|:::.|::|..:...:.|.:||:..:.|.:||..::..:::||.::|.
  Rat   285 TAVRLAELGWLHNKIRKYADQRSLDRSFGLVGQSFCAALHQELKEYYRLLSVLHSQLQL------ 343

  Fly   339 NGIANKGKKDSGPDAGDE--MTLFKLLAWYIKPLHRMQWLTKIADACQVKKGGDLASTVYDFLDN 401
                   :.|.|.:.|.|  :||.:||.|...|..|::.|..:.|.||.:|||:|||.|:.:...
  Rat   344 -------EDDQGVNVGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKT 401

  Fly   402 GNDMVNKLVEDLLTAICGPLVRMISKWILEGGISDMHREFFVKSIKDVGVDRLWHDKFRLRLPML 466
            |:..:..||:.:|:.:..|::..:.:||.:|.:.|.:.||||.|...|..|||||||:.||..|:
  Rat   402 GDPYMKSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMI 466

  Fly   467 PKFVPMDMANKILMTGKSINFLREICEEQGMMKERDELMKVMES--SASQIFSYTPDTSWHAAVE 529
            |.|:.||.:.|:|:.|||||||.::|.:|....:...:.|..||  .|:.:|: ..:.::...::
  Rat   467 PSFITMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPRDAADLFT-DLENAFQGKID 530

  Fly   530 TCYQQTSKHVLDIMVGPHKLLDHLHGMRRYLLLGQGDFISILIENMKNELERPGLDIYANDLTSM 594
            ..|.:|||::||::...:.||:|:..|||||||||||||..|::.:|.||.||...:|.::||.:
  Rat   531 AAYFETSKYLLDVLNRKYSLLEHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGI 595

  Fly   595 LDSALRCTNAQYDDPDILNHLDVIVQRPFNGDIGWNIISLQYIVHGPLAAML-ESTMPTYKVLFK 658
            |::|:|.||||:|.|:||..|||.:.....||.||::.||.|.|.||:|.:. ...|..|..:|.
  Rat   596 LETAVRATNAQFDSPEILKRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFN 660

  Fly   659 PLWRMKHMEFVLSMKIWKEQMGNAKALRTMKSEIGKASHRLNLFTSEIMHFIHQMQYYVLFEVIE 723
            .|||.|.||::|: .|.|..|.|||.||.| .|.....|:.::..||::|||||||||:.|||:|
  Rat   661 FLWRAKRMEYILT-DIRKGHMCNAKLLRNM-PEFSGVLHQCHILASEMVHFIHQMQYYITFEVLE 723

  Fly   724 CNWVELQKKMQKATTLDEILEAHEKFLQTILVGCFV-SNKASVEHSLEVVYENIIELEKWQSSFY 787
            |:|.||..::|:|..||.|:.|||.||.||...|.: ||...:.:.|..|::.||||:..|.:.|
  Rat   724 CSWDELWNRVQQAQDLDHIIAAHEAFLDTITSRCLLDSNSRVLLNQLRAVFDQIIELQNAQDTMY 788

  Fly   788 KDCFKELNARKELSKIVEKSEKKGVYGLTNKMILQRDQEAKIFAEKMDIACRGLEVIATDYEKAV 852
            :...:||..|.:..:..::.|.:|.:|:|.....:.::..:.|.:.:...|..|.::...|:..|
  Rat   789 RAALEELQRRLQFEEKKKQRETEGQWGVTAAEEEEENKRIREFQDSIPKMCSQLRILTHFYQGVV 853

  Fly   853 STFLMSLNSSDDPNLQLFGTRLDFNEYYKKRDTNLSKPLTFEHMRMSN 900
            ..||:.|.:|.|.:||....||||||:||.|:..|...|.....|.|:
  Rat   854 QQFLVLLTTSSDESLQFLSFRLDFNEHYKAREPRLRVSLGSRGRRSSH 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip91	NP_524919.2	Spc97_Spc98	236..758	CDD:282045	200/526 (38%)
Tubgcp3	NP_001100793.2	GCP_N_terminal	246..547	CDD:407574	99/316 (31%)
Tubgcp3	NP_001100793.2	Spc97_Spc98	550..881	CDD:398000	138/332 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343337
Domainoid	1	1.000	258	1.000	Domainoid score	I1930
eggNOG	1	0.900	-	-		E1_KOG2000
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1605
OMA	1	1.010	-	-		QHG55181
OrthoDB	1	1.010	-	-		D124154at33208
OrthoFinder	1	1.000	-	-		FOG0004051
OrthoInspector	1	1.000	-	-		oto97355
orthoMCL	1	0.900	-	-		OOG6_101925
Panther	1	1.100	-	-	LDO	PTHR19302
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3891
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810