DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip91 and Tubgcp3

DIOPT Version :9

Sequence 1:	NP_524919.2	Gene:	Grip91 / 48481	FlyBaseID:	FBgn0001612	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_932148.1	Gene:	Tubgcp3 / 259279	MGIID:	2183752	Length:	905	Species:	Mus musculus

Alignment Length:	953	Identity:	301/953 - (31%)
Similarity:	483/953 - (50%)	Gaps:	112/953 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VATNSTDISNIINEMIIC-IKGKQMPEVHEKAMDHLSKMIAAN--SRVIRDSNMLTERECVQKIM 72
            :||......|::.:.:.| |.|:...:|.:: .....::|.:|  ..|.||..::.|     ||.
Mouse     1 MATPDQKSPNVLLQNLCCRILGRSEADVAQQ-FQFAVRVIGSNFAPTVERDEFLVAE-----KIK 59

  Fly    73 KLLSARNKKEEGKTVSDHFNELYRKLTLTKCDPHM------RHSLMTHLLTMTDNSDAEKAVASE 131
            |.| .|.::|....:   |:||:|||       |.      :.|::..||.:           ||
Mouse    60 KEL-IRQRREADAAL---FSELHRKL-------HSQGVLKNKWSILYLLLNL-----------SE 102

  Fly   132 DPRTQCDNLT-------QILVSRLNSISSSIASLNEMGV------VNGNGVGAAAVTGAAAVTGA 183
            |||.|...:|       |.|....:|.....|....:.:      ......|:...:|.::: |.
Mouse   103 DPRKQASKVTSYASLFAQALPRDAHSTPYYYARPQTLPLNYQDRSTQAQSSGSLGSSGISSI-GM 166

  Fly   184 AAVTGAAAVTGAAASHSYDATQSSIGLRKQ----------------------SLPNYLDATKMLP 226
            ..::|...|.......|:.|.....|||:|                      ..||.|  ::.|.
Mouse   167 CGLSGPTPVQPFLPGQSHQAPGVGDGLRQQLGPRLAWTLTGNQPSSQTPTSKGFPNAL--SRNLT 229

  Fly   227 ESRHD-------------IVMSAIYSFTGVQGKYLKKDVVTGRFKLDQQNIKFLTTGQAGMLLRL 278
            .||.:             :|...:|.|.|:.||.:|.......:|::.:  ..|........:||
Mouse   230 RSRREGDPGGTLEVTEAALVRDILYVFQGIDGKNIKMSSTENCYKVEAK--ANLNKSLRDTAVRL 292

  Fly   279 SELGYYHDRVVKFSDVSTGFNAIGSMGQALISKLKEELANFHGQVAMLHDEMQRFRQASVNGIAN 343
            :|||:.|:::.|::|..:...:.|.:||:..:.|.:||..::..:::||.::|.
Mouse   293 AELGWLHNKIRKYADQRSLDRSFGLVGQSFCAALHQELKEYYRLLSVLHSQLQL----------- 346

  Fly   344 KGKKDSGPDAGDE--MTLFKLLAWYIKPLHRMQWLTKIADACQVKKGGDLASTVYDFLDNGNDMV 406
              :.|.|.:.|.|  :||.:||.|...|..|::.|..:.|.||.:|||:|||.|:.:...|:..:
Mouse   347 --EDDQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYM 409

  Fly   407 NKLVEDLLTAICGPLVRMISKWILEGGISDMHREFFVKSIKDVGVDRLWHDKFRLRLPMLPKFVP 471
            ..||:.:|:.:..|::..:.:||.:|.:.|.:.||||.|...|..|||||||:.||..|:|.|:.
Mouse   410 KSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFIT 474

  Fly   472 MDMANKILMTGKSINFLREICEEQGMMKERDELMKVMES--SASQIFSYTPDTSWHAAVETCYQQ 534
            ||.:.|:|:.|||||||.::|.:|....:...:.|..||  .|:.:|: ..:.::...::..|.:
Mouse   475 MDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPRDAADLFT-DLENAFQGKIDAAYFE 538

  Fly   535 TSKHVLDIMVGPHKLLDHLHGMRRYLLLGQGDFISILIENMKNELERPGLDIYANDLTSMLDSAL 599
            |||::||::...:.||:|:..|||||||||||||..|::.:|.||.||...:|.::||.:|::|:
Mouse   539 TSKYLLDVLNKKYSLLEHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAV 603

  Fly   600 RCTNAQYDDPDILNHLDVIVQRPFNGDIGWNIISLQYIVHGPLAAML-ESTMPTYKVLFKPLWRM 663
            |.||||:|.|:||..|||.:.....||.||::.||.|.|.||:|.:. ...|..|..:|..|||.
Mouse   604 RATNAQFDSPEILKRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRA 668

  Fly   664 KHMEFVLSMKIWKEQMGNAKALRTMKSEIGKASHRLNLFTSEIMHFIHQMQYYVLFEVIECNWVE 728
            |.||::|: .|.|..|.|||.||.| .|.....|:.::..||::|||||||||:.|||:||:|.|
Mouse   669 KRMEYILT-DIRKGHMCNAKLLRNM-PEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDE 731

  Fly   729 LQKKMQKATTLDEILEAHEKFLQTILVGCFV-SNKASVEHSLEVVYENIIELEKWQSSFYKDCFK 792
            |..::|:|..||.|:.|||.||.||...|.: ||...:.:.|..|::.||||:..|...|:...:
Mouse   732 LWNRVQQAQDLDHIIAAHEAFLNTITSRCLLDSNSRVLLNQLRAVFDQIIELQNAQDVMYRAALE 796

  Fly   793 ELNARKELSKIVEKSEKKGVYGLTNKMILQRDQEAKIFAEKMDIACRGLEVIATDYEKAVSTFLM 857
            ||..|.:..:..::.|.:|.:|:|.....:.::..:.|.:.:...|..|.::...|:..|..||:
Mouse   797 ELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIREFQDSIPKMCSQLRILTHFYQGVVQQFLV 861

  Fly   858 SLNSSDDPNLQLFGTRLDFNEYYKKRDTNLSKPLTFEHMRMSN 900
            .|.:|.|.:||....||||||:||.|:..|...|.....|.|:
Mouse   862 LLTTSSDESLQFLSFRLDFNEHYKAREPRLRVSLGSRGRRSSH 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip91	NP_524919.2	Spc97_Spc98	236..758	CDD:282045	200/526 (38%)
Tubgcp3	NP_932148.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..193		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..239		6/34 (18%)
		Spc97_Spc98	251..761	CDD:282045	200/527 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839518
Domainoid	1	1.000	257	1.000	Domainoid score	I2014
eggNOG	1	0.900	-	-		E1_KOG2000
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4609
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1654
Isobase	1	0.950	-	0	Normalized mean entropy	S4856
OMA	1	1.010	-	-		QHG55181
OrthoDB	1	1.010	-	-		D124154at33208
OrthoFinder	1	1.000	-	-		FOG0004051
OrthoInspector	1	1.000	-	-		oto93816
orthoMCL	1	0.900	-	-		OOG6_101925
Panther	1	1.100	-	-	LDO	PTHR19302
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R54
SonicParanoid	1	1.000	-	-		X3891
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750