DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip91 and alp4

DIOPT Version :9

Sequence 1:	NP_524919.2	Gene:	Grip91 / 48481	FlyBaseID:	FBgn0001612	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_596044.1	Gene:	alp4 / 2540392	PomBaseID:	SPBC365.15	Length:	784	Species:	Schizosaccharomyces pombe

Alignment Length:	556	Identity:	121/556 - (21%)
Similarity:	227/556 - (40%)	Gaps:	104/556 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 QVKKGGDLASTVYDFLDN--GNDMVNKLVEDLLTAICGPLVRMISKWILEGGISDMHREFFVKSI 446
            :|.|||.:.|.:.:.|..  |:.:..|::..||.....|..:|:::||..|.::|.:.||.:|..
pombe   251 KVCKGGQVISFLTESLTKYAGDPVARKILTYLLREASRPYTKMLNEWIHLGLVNDPYDEFMIKIH 315

  Fly   447 KDVG--------VDRLWHDKFRLRLPMLPKFVPMDMANKILMTGKSINFLREICEEQGMMKERDE 503
            |.:.        .|..|..::.:|...:|..: :|:.||:|..||.:|.:.| |.     |..:.
pombe   316 KGITSMQLDEDYTDEYWEKRYVIREDQVPPQL-LDLQNKVLFAGKYLNVVLE-CR-----KGVNN 373

  Fly   504 L--MKVMESSASQIF--SYTPDTSWHAAVETCYQQTSKHVLDIMVGPHKLLDHLHGMRRYLLLGQ 564
            |  :...:.:.:|:.  |...|.::...:...|...::.:|.::.....|..||:.::.|..|.|
pombe   374 LASLNAKDDTQNQLLWPSTFDDDNFTLNIMNAYVYANESLLQLLQSSQSLYAHLYSLKHYFFLDQ 438

  Fly   565 GDFISILIENMKNELERPGLDIYANDLTSMLDSALR-------------CTNAQYDDPDILNHLD 616
            .||.:..::|.::||.:|...|....|.|.||.|||             ....:.:...:::.|.
pombe   439 SDFFTTFLDNAQHELRKPAKYISITKLQSQLDLALRQPGTITATDPHKEYVTVEVNQTSLIDWLM 503

  Fly   617 VIVQ------------------------------RPFNG----------------DI-GWNIISL 634
            .||.                              |.|..                || |:..:.|
pombe   504 HIVSISGLEEGTSSQGNEVWNESITKQADVGNETRNFESEHNRSTQGTSKVGSDKDINGFETMQL 568

  Fly   635 QYIVHGPLAAML-ESTMPTYKVLFKPLWRMKHMEFVLSMKIWKEQMGNAKALRTMKSEIGKASHR 698
            .|.|..||:.:| ...:..|::||:....::|:|..|.....:....:|..|.:..::|.:....
pombe   569 CYKVPFPLSLILSRKAIIRYQLLFRYFLLLRHVEMQLENSWVQHSKNSAWRLNSSNAKIEQWKRN 633

  Fly   699 LNLFTSEIMHFIHQMQYYVLFEVIECNWVELQKKMQKATTLDEILEAHEKFLQTILVGCFVSNKA 763
            ..|..:.::.|:.::.||...||||.:|.:...:::.|.|:|.:::.|..||.|.|..|.::|.
pombe   634 SWLLRTRMLSFVQKIIYYTTSEVIETHWGKFMGELENARTVDNLMQEHIDFLDTCLKECMLTNS- 697

  Fly   764 SVEHSLEVVYENIIELEKWQSSFYKDCFKELNARKELSK---IVEKSEKKGVYGLTNKM--ILQR 823
                          .|.|.||.....|....:.....::   ::|.||:....|..:||  ||:|
pombe   698 --------------RLLKVQSKLLNTCAMFASYTSTFTRSLYLLENSEESFDEGRMDKMEEILRR 748

  Fly   824 DQEAKIFAEKMDIACRGLEVIATDYEKAVSTFLMSL 859
            .:::  |:..:..........|:....|:.:.:|.|
pombe   749 YEDS--FSRHLKSLVNACNYFASTETAALLSLVMKL 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip91	NP_524919.2	Spc97_Spc98	236..758	CDD:282045	100/448 (22%)
alp4	NP_596044.1	Spc97_Spc98	74..693	CDD:282045	100/448 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910