DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip91 and TUBGCP2

DIOPT Version :9

Sequence 1:	NP_524919.2	Gene:	Grip91 / 48481	FlyBaseID:	FBgn0001612	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001243546.1	Gene:	TUBGCP2 / 10844	HGNCID:	18599	Length:	930	Species:	Homo sapiens

Alignment Length:	748	Identity:	186/748 - (24%)
Similarity:	308/748 - (41%)	Gaps:	154/748 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 YLDATKMLPESRHDIVMSAIYSFTGVQGKYLKKDVVTGRFKLDQQNIKFLTTGQAGMLL-----R 277
            :|..|..|......:|...:|...||.|:|:....:.||     |:..||......:.:     |
Human   231 HLPGTLPLASQESAVVEDLLYVLVGVDGRYVSAQPLAGR-----QSRTFLVDPNLDLSIRELVHR 290

  Fly   278 LSELGYYHDRVVKFSDVSTGFNAIGSMGQALISKL----KEELANFHGQVAMLHDEMQRFRQASV 338
            :..:...:..|.:|.:..:.|. .|.:..||.:.:    ||.|. ...|:..||      ||
Human   291 ILPVAASYSAVTRFIEEKSSFE-YGQVNHALAAAMRTLVKEHLI-LVSQLEQLH------RQ--- 344

  Fly   339 NGIANKGKKDSGPDAGDEMTLFKLLAW-YIKPLHR-MQWLTKIADACQVKK----GGDLASTVYD 397
             |:               ::|.||  | ||:|..| |..|..:|.:  |.|    ||...|.::|
Human   345 -GL---------------LSLQKL--WFYIQPAMRTMDILASLATS--VDKGECLGGSTLSLLHD 389

  Fly   398 --FLDNGNDMVNKLVEDLLTAICGPLVRMISKWILEGGISDMHREFFVKS-------IKDVGVDR 453
              |...|:....:|...|..|...|...::.|||..|.|.|.:.||.|:.       |::...|:
Human   390 RSFSYTGDSQAQELCLYLTKAASAPYFEVLEKWIYRGIIHDPYSEFMVEEHELRKERIQEDYNDK 454

  Fly   454 LWHDKFRLRLPMLPKFVPMDMANKILMTGKSINFLREICEEQGMMKERDELMKVMESSASQIFSY 518
            .|..::.:....:|.|: ..||:|||.|||.:|.:||...:            |....|.:|...
Human   455 YWDQRYTIVQQQIPSFL-QKMADKILSTGKYLNVVRECGHD------------VTCPVAKEIIYT 506

  Fly   519 TPDTSWHAAVETCYQQTSKHVLDIMVGPHKLLDHLHGMRRYLLLGQGDFISILIENMKNELERPG 583
            ..:.::...:|..:...||.:||.::...:|:.||..::||.|:.||||....::..:.||.:|.
Human   507 LKERAYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFLMDQGDFFVHFMDLAEEELRKPV 571

  Fly   584 LDIYANDLTSMLDSALRCTNAQYDDP-------DILNHLDVIVQ-------------RPFNGD-- 626
            .||....|.::|:.|||.:.|. .||       |::.| |:|.|             ...:.|
Human   572 EDITPPRLEALLELALRMSTAN-TDPFKDDLKIDLMPH-DLITQLLRVLAIETKQEKAMAHADPT 634

  Fly   627 ----IGWNIISLQYIVHGPLAAML-ESTMPTYKVLFKPLWRMKHMEFVLSMKIWKEQMGNAKALR 686
                .|....|..|||..||:.:: ...:..|::||:.::..||:|..| ..:|   :.|..|
Human   635 ELALSGLEAFSFDYIVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQL-CSVW---ISNKTA-- 693

  Fly   687 TMKSEIGKASHRLNLFT--SEIMHFIHQMQYYVLFEVIECNWVELQKKMQKATTLDEILEAHEKF 749
             .:..:..|......||  ..:::|:..:|||::|||:|..|..|:|.::.|:.:|::|..|..|
Human   694 -KQHSLHSAQWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEKNLKSASNIDDVLGHHTGF 757

  Fly   750 LQTILVGCFVSNKASVEHSLEVVYENIIELEKWQSSFYKDCFKELNARKELSKIVEKSEKKGVYG 814
            |.|.|..|.::|.               ||.|..|.....|....|..::.::.::...:.|...
Human   758 LDTCLKDCMLTNP---------------ELLKVFSKLMSVCVMFTNCMQKFTQSMKLDGELGGQT 807

  Fly   815 LTNKMIL----------QRDQEAKIFAEKMDIA--CRGLEVIATDYEKAVSTFLMSLNSSDDPNL 867
            |.:..:|          :::...|..||..|..  ..|.|.....::|..|..|:.|.:    .|
Human   808 LEHSTVLGLPAGAEERARKELARKHLAEHADTVQLVSGFEATINKFDKNFSAHLLDLLA----RL 868

  Fly   868 QLFGT------------RLDFNEYYKKRDTNLS 888
            .::.|            |||||.:|.:|...||
Human   869 SIYSTSDCEHGMASVISRLDFNGFYTERLERLS 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip91	NP_524919.2	Spc97_Spc98	236..758	CDD:282045	150/574 (26%)
TUBGCP2	NP_001243546.1	GCP_N_terminal	246..534	CDD:407574	83/336 (25%)
TUBGCP2	NP_001243546.1	Spc97_Spc98	537..893	CDD:398000	96/383 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D124154at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920