| Sequence 1: | NP_000594.2 | Gene: | NOS3 / 4846 | HGNCID: | 7876 | Length: | 1203 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_523541.2 | Gene: | Nos / 34495 | FlyBaseID: | FBgn0011676 | Length: | 1349 | Species: | Drosophila melanogaster |
| Alignment Length: | 1221 | Identity: | 567/1221 - (46%) |
|---|---|---|---|
| Similarity: | 755/1221 - (61%) | Gaps: | 84/1221 - (6%) |
- Green bases have known domain annotations that are detailed below.
|
Human 16 GLGLGLGLGLCGKQGPATPAPEPSRAPASLLPPAPEHSPPSSPLTQ------------PPEG--- 65
Human 66 --PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSL--VFPRKLQGRPSPGPPAPEQLLSQ 126
Human 127 ARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWG 191
Human 192 KLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQ 256
Human 257 QDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLE 321
Human 322 WFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLD 386
Human 387 TRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPP 451
Human 452 ISGSLTPVFHQEMVNYFLSPAFRYQPDPW------KG-SAAKGTGITRKKTFKEVANAVKISASL 509
Human 510 MGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTF 574
Human 575 GNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSD--------------PL--- 622
Human 623 --VSSWRRKRKESSNT---DSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQL 682
Human 683 GQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSAQAEGLQLL 747
Human 748 PGLIHVHRRKMF--QATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLV 810
Human 811 EALLSRVEDPPAPTEPVAVEQL-EKGSPGGPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLL 874
Human 875 RLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRY 939
Human 940 YSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPD 1004
Human 1005 PSLPCILVGPGTGIAPFRGFWQE--RLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQR 1067
Human 1068 GVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILA 1132
Human 1133 TEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEV------TSRIRTQS 1177 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| NOS3 | NP_000594.2 | Flavodoxin_1 | 522..698 | CDD:306716 | 85/197 (43%) |
| FNR_like | 762..1164 | CDD:323647 | 180/404 (45%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..71 | 17/71 (24%) | |||
| NOS_oxygenase_euk | 68..480 | CDD:238410 | 237/413 (57%) | ||
| Interaction with NOSIP. /evidence=ECO:0000269|PubMed:11149895 | 98..486 | 231/396 (58%) | |||
| Calmodulin-binding. /evidence=ECO:0000255 | 491..510 | 8/18 (44%) | |||
| Nos | NP_523541.2 | NOS_oxygenase_euk | 216..624 | CDD:238410 | 237/413 (57%) |
| CysJ | 669..1323 | CDD:223446 | 282/667 (42%) | ||
| Flavodoxin_1 | 673..863 | CDD:278677 | 85/197 (43%) | ||
| Nitric_oxide_synthase | 931..1328 | CDD:99799 | 180/402 (45%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 525 | 1.000 | Domainoid score | I292 |
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 1114 | 1.000 | Inparanoid score | I227 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG46820 | |
| OrthoDB | 1 | 1.010 | - | - | D56017at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001418 | |
| OrthoInspector | 1 | 1.000 | - | - | otm42050 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_103176 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR19384 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R4692 |
| SonicParanoid | 1 | 1.000 | - | - | X3122 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 13 | 13.010 | |||||