DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CkIIalpha and CKA2

DIOPT Version :9

Sequence 1:	NP_001036624.1	Gene:	CkIIalpha / 48448	FlyBaseID:	FBgn0264492	Length:	336	Species:	Drosophila melanogaster
Sequence 2:	NP_014704.1	Gene:	CKA2 / 854227	SGDID:	S000005587	Length:	339	Species:	Saccharomyces cerevisiae

Alignment Length:	319	Identity:	189/319 - (59%)
Similarity:	236/319 - (73%)	Gaps:	2/319 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SAARVYTDVNAHKPDEYWDYENYV-VDWGNQDDYQLVRKLGRGKYSEVFEAINITTTEKCVVKIL 68
            |.||||.:....:|.||||||..| :|||...:|:::.|:|||||||||....|...:|||:|:|
Yeast    17 SVARVYKNACEERPQEYWDYEQGVTIDWGKISNYEIINKIGRGKYSEVFSGRCIVNNQKCVIKVL 81

  Fly    69 KPVKKKKIKREIKILENLRGGTNIITLLAVVKDPVSRTPALIFEHVNNTDFKQLYQTLTDYEIRY 133
            ||||.|||.||:|||.||.||.|::.|..:|:|..|:.||||||.:.|.||:.||.|....:|:|
Yeast    82 KPVKMKKIYRELKILTNLTGGPNVVGLYDIVQDADSKIPALIFEEIKNVDFRTLYPTFKLPDIQY 146

  Fly   134 YLFELLKALDYCHSMGIMHRDVKPHNVMIDHENRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGP 198
            |..:||.|||||||||||||||||.|||||...|||||||||||||||||.:|||||||||.|||
Yeast   147 YFTQLLIALDYCHSMGIMHRDVKPQNVMIDPTERKLRLIDWGLAEFYHPGVDYNVRVASRYHKGP 211

  Fly   199 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEELYAYLDKYNIDL 263
            ||||:...||||||:||:|||||:::|:|||||.|..|.||||:||.||||:||..||.||.:.|
Yeast   212 ELLVNLNQYDYSLDLWSVGCMLAAIVFKKEPFFKGSSNPDQLVKIATVLGTKELLGYLGKYGLHL 276

  Fly   264 DPRFHDILQRHSRKRWERFVHSDNQHLVSPEALDFLDKLLRYDHVDRLTAREAMAHPYF 322
            ...:.:|::..::|.|..|:.|:.: |..||.:|.:|.||||||.:||||:|||.|.:|
Yeast   277 PSEYDNIMRDFTKKSWTHFITSETK-LAVPEVVDLIDNLLRYDHQERLTAKEAMDHKFF 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CkIIalpha	NP_001036624.1	STKc_CK2_alpha	18..322	CDD:271034	183/304 (60%)
CKA2	NP_014704.1	STKc_CK2_alpha	30..335	CDD:271034	184/306 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341480
Domainoid	1	1.000	363	1.000	Domainoid score	I125
eggNOG	1	0.900	-	-		E1_KOG0668
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H90874
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S214
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000968
OrthoInspector	1	1.000	-	-		oto100182
orthoMCL	1	0.900	-	-		OOG6_100821
Panther	1	1.100	-	-	O	PTHR24054
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X569
TreeFam	1	0.960	-	-
	12	11.650