Protein Alignment Kebab and NDC80

DIOPT Version :10

• Sequence 1: NP_001259900.1
• Gene: Kebab / 48440
• FlyBaseID: FBgn0028952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_006092.1
• Gene: NDC80 / 10403
• HGNCID: 16909
• Length: 642
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 95/472 - (20%)
• Similarity: 170/472 - (36%)
• Gaps: 134/472 - (28%)

  Fly   165 KSHTCIPSSEP-----QP---------IRPKLILE----------------RERQESITNRLAST 199
            |.||.:..|.|     ||         :..||.|:                .|....:.::|...
Human   193 KIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGADSFDEMNAELQSKLKDL 257

  Fly   200 -SIDRLKTKPPRSSFTSSRLLVPQMGFSYPKDPKRLHESDKGIK----------------LTTSK 247
             ::|..|.:...:...:....:.::.....|:|.|| ||.:.:|                |.:..
Human   258 FNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRL-ESLRKLKASLQGDVQKYQAYMSNLESHS 321

  Fly   248 RKLDFKTE-LGTDWLRRELEKIGKEWRKKTDYQLRQLISGFVKQLVRLLPFN------GITFSHL 305
            ..||.|.. |..:..|.|||   .|..|:.:.:|:.:|......:..:...|      ..|.:.|
Human   322 AILDQKLNGLNEEIARVELE---CETIKQENTRLQNIIDNQKYSVADIERINHERNELQQTINKL 383

  Fly   306 SRDCYVQQMVEALQQLQYTKKVNKSWLQTPNSTQAIAHVLELLNFLLDVLEHRKGEGMCALPVVS 370
            ::|...:|.....::|:|.:  .|..::|           :|..:      |:....:..:|..:
Human   384 TKDLEAEQQKLWNEELKYAR--GKEAIET-----------QLAEY------HKLARKLKLIPKGA 429

  Fly   371 EKQRIEQLASASGTSYDVMSLQQKFENIKIE---------KERLNNYQESLMPESPVSKDMDK-- 424
            |        ::.|..:::....:...|..::         ||.||..:|.      ::|.::|
Human   430 E--------NSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEE------INKALNKKM 480

  Fly   425 ------------VTERDGNQDFVRLLDFQKETLHELQLQRLRLQE------FSELVSLAKIKLKR 471
                        :||   ::..||.|..:.:.|.:|..|:::..|      .|||.||.|.|...
Human   481 GLEDTLEQLNAMITE---SKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKHLL 542

  Fly   472 CCKANKQCIEAFN--DQIQDLADCVVL----RNRNIG-----LLTQLHLNDNPKEEELHERMKQL 525
            ....|:...||.|  |.:|.....||.    ..|.:|     ||..:..:....|:.|.|::.::
Human   543 ESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHLEEQIAKV 607

  Fly   526 QRLYEDNYSNLLQLNIK 542
            .|.||:..|..|..|||
Human   608 DREYEECMSEDLSENIK 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kebab	NP_001259900.1	None
NDC80	NP_006092.1	Interaction with the N-terminus of CDCA1	1..445		48/282 (17%)
		Nuclear localization	1..250		11/56 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..74
		Ndc80_HEC	51..206	CDD:461058	5/12 (42%)
		Interaction with RB1	128..251		11/57 (19%)
		DUF5595	213..285	CDD:465636	7/71 (10%)
		SMC_prok_B	240..>623	CDD:274008	82/422 (19%)
		Interaction with NEK2 and ZWINT. /evidence=ECO:0000269|PubMed:16732327	251..618		80/406 (20%)
		Interaction with SMC1A	251..431		36/210 (17%)
		Interaction with PSMC2 and SMC1A	361..547		38/221 (17%)
		Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex	446..642		47/188 (25%)