DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5707 and ABHD8

DIOPT Version :9

Sequence 1:	NP_001246563.1	Gene:	CG5707 / 48422	FlyBaseID:	FBgn0026593	Length:	361	Species:	Drosophila melanogaster
Sequence 2:	NP_078803.4	Gene:	ABHD8 / 79575	HGNCID:	23759	Length:	439	Species:	Homo sapiens

Alignment Length:	307	Identity:	60/307 - (19%)
Similarity:	110/307 - (35%)	Gaps:	78/307 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LHGWLDNLGTWDKLLPLLPKHLG--VLCIDLPGHGYSSKLPEGIAYHFVDYLCVILRVMEEYRWQ 113
            :||...:|..|.:.|....: ||  |:..||.|||.||......||.|......:..:.:.|..:
Human   181 IHGVGGSLAIWKEQLDFFVR-LGYEVVAPDLAGHGASSAPQVAAAYTFYALAEDMRAIFKRYAKK 244

  Fly   114 KVSLMAHSMSAMLCFVFASLYPHRTDMLVSIDIVKTRYRKP--------PSQIDYLRKNIEGYIV 170
            :..|:.||.....|...|..||.....::.|:.......:|        |:.:.:.......:..
Human   245 RNVLIGHSYGVSFCTFLAHEYPDLVHKVIMINGGGPTALEPSFCSIFNMPTCVLHCLSPCLAWSF 309

  Fly   171 EDERFANSKRQEPPAYTYTEMEQVLYKGTDYSVELENCRHILERNISRSTKFPAKFFFSRDGRCK 235
            ....||....:|         :|:|.:|..::|                :.|..:...|.    :
Human   310 LKAGFARQGAKE---------KQLLKEGNAFNV----------------SSFVLRAMMSG----Q 345

  Fly   236 YYTE----FHTSPPFAAELARTIKNVPYCVIKGSESNYIDEQSDE------VIGILRENNPHFEL 290
            |:.|    :|      |||     .||..::.|....::..:.|:      ::..|:..:
Human   346 YWPEGDEVYH------AEL-----TVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKLID----- 394

  Fly   291 HEVQGTHHVHLNNAQGVAAVINPFILHHRPPHLENWTVDGTDETLPE 337
               :|:|.|.|...:.|..:::.|:|         |..:.:.:.|||
Human   395 ---EGSHMVMLECPETVNTLLHEFLL---------WEPEPSPKALPE 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5707	NP_001246563.1	MhpC	46..318	CDD:223669	56/286 (20%)
ABHD8	NP_078803.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..156
		MhpC	156..416	CDD:223669	54/283 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142112
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840